1,720,975 research outputs found
[Drug-induced hepatotoxicity: clinical and biochemical features of 26 patients and a review of the literature].
No full textDrug-induced hepatotoxicity: clinical and biochemical features of 26 patients and
a review of the literature. Drug-induced hepatotoxicity is a major cause of
iatrogenic diseases. More than 1200 compounds are involved and can reproduce the
full range of hepatic disorders. Clinical and biochemical features of 26 patients
(13 men and 13 women, mean age 62 years) observed during a 6 years period were
reported. The potential hepatotoxicity of some herbal remedies are described,
emphasizing the relevance of misconception that herbs are devoid of toxic
potential because they are natural products. Meticulous taking of patient
history, drug history with specific queries about ingestion of herbal and dietary
supplements, and the exclusion of other causes of liver disease are important for
the early detection of drug-induced hepatotoxicity and rapid discontinuation of
suspected drug(s)
Peribronchial lymph node metastasis from prostate cancer in pulmonary lobectomy for primary lung adenocarcinomas: a possible source of pitfall with therapeutic consequences.
No full textALK-positive adenocarcinoma of the lung expressing neuroendocrine markers and presenting as a "pituitary adenoma"
No full textWe report an ALK-rearranged adenocarcinoma of the lung presenting as a pituitary metastasis, clinically simulating a pituitary adenoma. The patient, a 50 year-old, former-smoking woman was admitted with a Parinaud's syndrome characterized by progressive oculomotor impairment of visual verticality, bitemporal hemianopsia and nystagmus. Imaging studies showed a sellar tumor and the biopsy revealed a TTF-1 and napsin positive lung adenocarcinoma strongly expressing synaptophysin and CD5 6, also harboring ALK rearrangement. A subsequent CT scan disclosed the primary lung mass of the left upper lobe. The patient progressed after 4 cycles of cisplatin/pemetrexed as first line treatment, but showed a partial response and a significant clinical benefit from the combination of ceritinib and nivolumab in a phase Ib trial.Despite its central nervous system tropism, ALK-rearranged adenocarcinoma manifesting with pituitary gland involvement was never reported. Second generation ALK inhibitors seem the best therapeutic strategy
Localized pleuropulmonary crystal-storing histiocytosis: 5 cases of a rare histiocytic disorder with variable clinicoradiologic features.
No full text
Clear cell carcinoid of the appendix: an uncommon variant of lipid-rich neuroendocrine tumor with a broad differential diagnosis.
No full textAtypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor.
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