1,720,974 research outputs found
Supporting data for "3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments"
No full textA full description of the data set is included in the file "Readme_Meng_Tumor_Model.txt".The data set includes the experimental data and the corresponding code files for " 3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments", Fanben Meng, Carolyn M Meyer, Daeha Joung, Daniel A Vallera, Michael C McAlpine, Angela Panoskaltsis‐Mortari, Adv. Mater. 2019, 31 (10), 1806899. The development of 3D in vitro models capable of recapitulating native tumor microenvironments could improve the translatability of potential anticancer drugs and treatments. Here, 3D bioprinting techniques are used to build tumor constructs via precise placement of living cells, functional biomaterials, and programmable release capsules. This enables the spatiotemporal control of signaling molecular gradients, thereby dynamically modulating cellular behaviors at a local level. Vascularized tumor models are created to mimic key steps of cancer dissemination (invasion, intravasation, and angiogenesis), based on guided migration of tumor cells and endothelial cells in the context of stromal cells and growth factors. The utility of the metastatic models for drug screening is demonstrated by evaluating the anticancer efficacy of immunotoxins. These 3D vascularized tumor tissues provide a proof-of-concept platform to i) fundamentally explore the molecular mechanisms of tumor progression and metastasis, and ii) preclinically identify therapeutic agents and screen anticancer drugs.National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (Award No. 1R21EB022830)A seed grant from the UMN Institute for Engineering in MedicineA Pilot Project award from the UMN Prostate and Urologic Cancer Translational WorkgroupNational Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (Award No. 1DP2EB020537)Cancer Bioengineering Fellowship, UMN Physical Sciences in Oncology Center (PSOC)Meng, Fanben; Meyer, Carolyn M; Joung, Daeha; Vallera, Daniel A; McAlpine, Michael C; Panoskaltsis-Mortari, Angela. (2020). Supporting data for "3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments". Retrieved from the University Digital Conservancy, https://doi.org/10.13020/xxnh-v194
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Functional molecular transport junctions based on nanogap structures
No full textThe use of individual molecules as functional components in electronic circuits offers the great opportunity to improve and revolutionize electronic systems. With the rapid achievement of nanofabrication, molecular electronic devices have been realized based on the investigation of electron properties of molecules. However, the study to build molecular architectures with electronic functions still leaves us a lot of room for improvement and optimization. Hence, this dissertation focuses on the exploration of hybridized electronic systems with judiciously designed molecules and metal nanostructures, to undertake advanced and complex functions.
Herein, the newly-developed on-wire lithography (OWL) is employed to fabricate nanogaps as nanoelectrode pairs for the formation of molecular transport junctions (MTJs), the most essential structures in molecular electronics. In order to obtain more complex nanodevices with advanced functions, rationally designed or selected molecules are utilized to functionalize the nanogap structure, while several external stimulations are also introduced to modulate the device performance.
Firstly, photo-modulable MTJs are developed via OWL-generated nanogaps functionalized by rationally designed and synthesized complexes with the photochromic dithienylethene unit(s) bearing the electro-active ruthenium fragments. A reversible and repeatable bi-state conductive switching upon alternate irradiation of UV and visible light is distinctly observed. Then, more external stimulations are introduced and orthogonally modulated MTJs are further achieved. The addressable and stepwise control of molecular isomerization is repeatedly and reversibly completed with a judicious use of the orthogonal optical and electrochemical. Through the rational design, these photo-/electro-cooperative nanodevices can be applied as resettable electronic logic gates for Boolean computing.
Besides chemically synthesized organometallic complexes, natural biomolecules are also used to functionalize nanogap structures. A programmable controllable and reproducible memristive behavior is achieved by natural ferritin-based MTJs, which can be applied for nonvolatile memory. Additionally, the rapid development of biotechnology provides us another option to improve the device function or performance. By tuning the amount of iron inside an engineered ferritin, the ON/OFF ratio of conductance switching of such protein-based nanodevices is modulated accordingly, suggesting that protein molecules can be tailored using biotechnology to suit the specific requirements of molecular devices. These works provide direct proof that natural biomolecules as a parallel choice of chemically synthesized complex can be used to fabricate functional nanodevices.
In conclusion, we develop advanced molecular nanodevices based on the feasible platform of precise nanogap structures fabricated by OWL, under various external controls. Both the synthetic chemistry and natural biosystem have been demonstrated to present enormous resources that fulfill the requirement of molecular devices. With chemical or biological modification of molecular architectures, the function and performance can be obviously improved. Therefore, after optimizing fabrication and operative conditions, such functional MTJs show promising applications in multifunctional nanocircuits.DOCTOR OF PHILOSOPHY (MSE
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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