96 research outputs found
Toxicological profile for RDX
No full text"Draft for public comment (update).""Comment period ends November 19, 2010"--Cover.RDX stands for Royal Demolition eXplosive. It is also known as cyclonite or hexogen.prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.Chemical manager(s)/author(s): Cassandra Smith, Henry Abadin, Division of Toxicology and Environmental Medicine, Atlanta; Lisa Ingerman, Fernando T. Llados, Lynn E. Barber, SRC, Inc., North Syracuse, NY.Includes bibliographical references (p. 139-169).200-2004-0979
Toxicological Profile for RDX [2012]
No full textprepared by Research Triangle Institute."January 2012.""Contract no. 205-93-0606."RDX stands for Royal Demolition eXplosive. It is also known as cyclonite or hexogen.Chemical manager(s)/author(s): Henry Abadin, Cassandra Smith, Division of Toxicology and Environmental Medicine, Atlanta; Lisa Ingerman, Fernando T. Llados, Lynn E. Barber, Daniel Plewak, Gary L. Diamond, SRC, Inc., North Syracuse, NY."This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary." - p. v.Mode of Access: World Wide Web as an Acrobat .pdf file (4.3 MB, 229 p.).Includes bibliographical references (p. 147-166)
Persistent stress during pregnancy influences thymic development in murine offspring
No full textPersistent stress during pregnancy influences thymic development in murine offspring
Alex Schroeder1*, Cassandra M. Juran1,2, Carol Mitchell1, and Amber M. Paul1,2
1Embry-Riddle Aeronautical University, Department of Human Factors and Behavioral Neurobiology, Daytona Beach, FL
2Blue Marble Space Institute of Science, NASA Ames Research Center, Moffett Field, CA
*Presenting Author
Thriving in spaceflight presents a unique challenge for humans. Exposure to extreme socioenvironmental stressors, such as altered gravity, ionizing radiation, and social isolation all can affect human biology. It is understood that physiological and psychological stress can disrupt gestation and reproduction processes in humans, as well. Using the mouse model, Chronic Unpredictable Mild Stress (CUMS), we can assess the influence of socioenvironmental stress on various biological systems, including the relationship between immune and reproductive systems. The thymus is an important gland involved in early life immune development and is sensitive to external factors that can disrupt T cell receptor diversity and antigen specificity. Due to this, we assessed retrospective, open-sourced data from GeneLab Open Science Directory (OSD-287). These data consist of thymic transcriptomes of one-day old pups born to dams that were exposed to CUMS for three-weeks. We aim to identify thymic immune pathways and activities that are involved in T cell development. Therefore, we hypothesize that CUMS exposure in dams will impair antigen presentation pathways and T cell tolerance processes in the thymus of pups. In brief, this project will identify processes that engage T cell activity in pup thymic development and examine the consequences of socioenvironmental stress in gestation
MYTHOLOGY AND FEMINISM IN CHRISTA WOLF\u27S NOVEL CASSANDRA
No full textMagistrsko delo obravnava delo nemške pisateljice Christe Wolf, Kasandra. Avtorica preko glavne protagonistke prikaže svoj odnos do mitologije in feminizma. Gre za roman, ki je avtorici prinesel veliko nagrad, predvsem pa je prejela veliko pozitivnih kritik, čeprav se v romanu skrivata podoba sedanjega časa in kritičen odnos do sodobnih razmer.
V romanu je precej povezav z avtorico, zato so v nalogi opisani biografski podatki Christe Wolf, njeno razmišljanje o sodobni svetovni politiki in vlogi ženske v »moškem« svetu. V teoretičnemu delu magistrske naloge so predstavljeni različni vidiki mitologije in feminizma, ki so izjemnega pomena za razumevanje romana. Pri teoriji mitologije smo se oprli na raziskave Meletinskega, zanimale so nas tudi sodobne predelave mitov, saj je Wolfova rekonstruirala mit o trojanski vojni. Opisano je tudi obdobje antične Grčije, družbeno-politična ureditev in vloga žensk v antični Grčiji. Ker je Wolfova za okvir zgodbe vzela Homerjevo Iliado, je v magistrski nalogi opisan tudi t. i. »Homerski svet«. V nadaljevanju teoretičnega dela naloge je predstavljen feminizem: pojasnili smo teorijo feminizma in spolov, ter vlogo ženske in ženskega pisanja. Pri tem je največ poudarka na raziskavi Toril Moi, ki je zelo natančno raziskala pojem in teorijo feminizma.My master\u27s degree thesis discusses the novel Cassandra written by German author Christa Wolf. The author reveals her attitude towards feminism and mythology through the main protagonist. The novel has been rewarded several times and the author has received many good reviews in spite of her critical attitude towards contemporary conditions.
Since the novel includes many autobiographical elements, the thesis contains also Christa Wolf\u27s biography, her thinking about contemporary world politics and a role of a woman in the \u27\u27man\u27s\u27\u27 world. Different aspects of mythology and feminism presented in the theoretical part enable easier comprehension of the novel. When analysing the theory, we refered to the researches of Meletinski, we were interested in contemporary remaking of myths, since Wolf reconstructed the myth of the Trojan War. I also described the period of antiquity, sociopolitical order and the role of women in ancient Greece. Wolf\u27s frame of the story is Homer\u27s Iliad, therefore I also decided to describe the so-called \u27\u27Homer\u27s world\u27\u27. Further we clarified the theory of feminism and gender including the role of women and their writing. There is a great emphasis especially on the research of Toril Moi, who had precisely researched the concept and the theory of feminism
South African travel writing and bias
No full textIncludes bibliographical references (leaves 92-96).This thesis spotlights the travel and leisure magazine industry within South Africa. It contends that the travel writing genre is susceptible to a number of biases, both past and present, which ultimately affect the way its overall content is produced and presented to the public. This work was substantiated through a set of qualitative interviews with key professionals within the South African travel and leisure magazine industry, as well as through a theme- based content analysis of a number of local travel writing publications. This study adds to a rather extensive line of research written on the topic of travel writing regarding a number of older criticisms of bias including 'othering', escapism, and gendering. However, it also focuses on a number of more modem biases such as direct advertising, advertorial usage, as well as the acceptance of 'freebies' and barter agreements, none of which has been given much attention in previous research. The sheer existence of these and other biases within the modem South African travel and leisure magazine industry exhibits an absolute necessity of examination into such a topic, especially given the importance and overall influence that the travel writing industry has on a country's economic standing and overall image
Does Reading Violent Books Increase Aggression? Perceptions of an Overlooked Medium
No full textIn the ongoing media violence debate, video games, movies, and television are regular targets of scrutiny. Yet, largely absent from the discussion is a popular, age-old medium: the book. Do people think that reading violent subject matter can increase aggression? How do first- and third-person perceptions differ? Using an online survey, the author collected quantitative data on adults’ (N = 160) perceptions of how much violent books affect aggression in themselves, the average adult, and the average child. The author hypothesized that participants would perceive the medium to have stronger effects on other adults\u27 aggression than on their own. The author also hypothesized that participants would perceive violent books to have stronger effects on children\u27s aggression than on adults\u27 aggression. Mean perceived effects all fell between 1 (Not at all) and 4 (Somewhat) per the survey’s 7-point Likert-type scale. Running two-tailed paired sample t tests, the author found both hypotheses to be supported. The author concludes that books are a largely unexplored medium within media effects research; there is more to be understood about their actual and perceived negative effects, as well as those of related formats.
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Verbal abuse by parents who maltreat or are at-risk for maltreatment of children: predictors and interventions
No full textExcessive verbal abuse by parents is psychologically and emotionally damaging to children. Studies of the effects of verbal abuse on children have found that children exposed to parental verbal abuse develop internalized problems including anxiety, depression, delayed mental development, and general health problems; and externalized behaviors, mainly aggression. These behaviors continue into adulthood. Verbal abuse is an especially acute problem in the population of families at risk of losing their child(ren) because of maltreatment or neglect. Despite the fact that the best way to stop or prevent verbal abuse is to understand its causes, verbal abuse in these families is virtually unstudied; even in the general population, the number of studies is small. This thesis is one of the first studies of the predictors of verbal abuse in at-risk populations.
A secondary analysis of the LONGSCAN longitudinal baseline data (visits at ages 4, 6, and 8) was undertaken to measure the influence of the factors identified in studies of the general population on the likelihood of verbal abuse in a sample of low income, African American, White, and Hispanic mothers (N=862), mostly drawn from an at-risk population. The Conflicts Tactic Scale was used to categorize mothers as verbally abusive or not, and determine the frequency of verbal abuse. Logistic regression was used to measure the predictive value of the factors identified in studies of the general population. Changes in the rates of verbal abuse from visit 4 to visit 6 and from visit 6 to visit 8 were used to measure the efficacy of interventions.
The results indicate that the demographics of the verbally abusive population were indistinguishable from those of the non-abusive population. The predictors of verbal abuse identified from studies of the general population were found not to be good predictors of abuse in the at-risk group. Anger, manifested by throwing, grabbing, or pushing, however, was found to be highly correlated with verbal abuse. No interventions significantly reduced abuse.
Implications for practice and future research are discussed.Ph.D.Includes bibliographical references (p. 195-202)
Food assets for whom? : Community perspectives on food asset mapping in Canada : [infographic]
No full textThis infographic is based on the following scholarly article: Soma, T., Shulman, T., Li, B., Bulkan, J., & Curtis, M. (2022). Food assets for whom? Community perspectives on food asset mapping in Canada. Journal of Urbanism: International Research on Placemaking and Urban Sustainability, 15(3), 322–339. This undergraduate student work is a product of a collaboration between the Making Research Accessible initiative (MRAi), researchers, Dr. Katie Fitzpatrick, and the students of ASTU 100 at UBC. This student work has been reviewed by the lead author of the original item. Revisions provided by the lead author have been incorporated into the student work with support from the UBC Learning Exchange and members of the MRAi. The reader should bear in mind that this is a student research project/report and is not an official document of UBC.Arts, Faculty ofUnreviewedUndergraduat
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia
No full textFunding Information: This project was funded by the European Research Council (Project: M-IMM 647355), Academy of Finland Heal-Art consortium (314442), and ERA PerMed (JAKSTAT-TARGET consortium), Sigrid Juselius Foundation, Signe and Ane Gyllenberg Foundation, Helsinki Institute for Life Science, Cancer Foundation Finland, and Ministry of Education, Culture, Sports, Science and Technology of Japan (Kaken 20K08709). J.H. was supported by Finnish Hematology Association, Blood Disease Research Foundation, Helsinki Institute for Life Science, Biomedicum Helsinki Foundation, Finnish Medical Foundation. T.L. was supported by Academy of Finland (Decision 311081). RZ was supported by Italian Association for Cancer Research (AIRC #20216).?F.I. was supported by KAKEN 20K08709. from Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Single-cell RNA sequencing and amplicon sequencing were performed at the Institute for Molecular Medicine Finland FIMM Technology Centre and Finnish Functional Genomics Centre, Turku Bioscience, which are supported by Biocenter Finland. We acknowledge Jay Klievink, Sofie Lundgren, Anita Kumari, and Ella Piekkari for the processing of samples from healthy controls. We acknowledge Emmi Rehn for providing a modified script of GLIPH that was used for the previous version of the findings. We acknowledge the computational resources provided by the Aalto Science-IT project. Funding Information: This project was funded by the European Research Council (Project: M-IMM 647355), Academy of Finland Heal-Art consortium (314442), and ERA PerMed (JAKSTAT-TARGET consortium), Sigrid Juselius Foundation, Signe and Ane Gyllenberg Foundation, Helsinki Institute for Life Science, Cancer Foundation Finland, and Ministry of Education, Culture, Sports, Science and Technology of Japan (Kaken 20K08709). J.H. was supported by Finnish Hematology Association, Blood Disease Research Foundation, Helsinki Institute for Life Science, Biomedicum Helsinki Foundation, Finnish Medical Foundation. T.L. was supported by Academy of Finland (Decision 311081). RZ was supported by Italian Association for Cancer Research (AIRC #20216). F.I. was supported by KAKEN 20K08709. from Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Single-cell RNA sequencing and amplicon sequencing were performed at the Institute for Molecular Medicine Finland FIMM Technology Centre and Finnish Functional Genomics Centre, Turku Bioscience, which are supported by Biocenter Finland. We acknowledge Jay Klievink, Sofie Lundgren, Anita Kumari, and Ella Piekkari for the processing of samples from healthy controls. We acknowledge Emmi Rehn for providing a modified script of GLIPH that was used for the previous version of the findings. We acknowledge the computational resources provided by the Aalto Science-IT project. Funding Information: T.L. is a member of the scientific advisory boards and hold stock options of Keystone Nano, Dren Bio, and Kymera Therapeutics (not related to this project). S.M. has received honoraria and research funding from BMS and research funding from Novartis and Pfizer (not related to this project). The remaining authors declare no competing interests. Publisher Copyright: © 2022, The Author(s).T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common. Although T-LGLL has been described as a chronic T cell response to an antigen, the function of the non-leukemic immune system in this response is largely uncharacterized. Here, by utilizing single-cell RNA and T cell receptor profiling (scRNA+TCRαβ-seq), we show that irrespective of STAT3 mutation status, T-LGLL clonotypes are more cytotoxic and exhausted than healthy reactive clonotypes. In addition, T-LGLL clonotypes show more active cell communication than reactive clones with non-leukemic immune cells via costimulatory cell–cell interactions, monocyte-secreted proinflammatory cytokines, and T-LGLL-clone-secreted IFNγ. Besides the leukemic repertoire, the non-leukemic T cell repertoire in T-LGLL is also more mature, cytotoxic, and clonally restricted than in other cancers and autoimmune disorders. Finally, 72% of the leukemic T-LGLL clonotypes share T cell receptor similarities with their non-leukemic repertoire, linking the leukemic and non-leukemic repertoires together via possible common target antigens. Our results provide a rationale to prioritize therapies that target the entire immune repertoire and not only the T-LGLL clonotype.Peer reviewe
The role of nucleus accumbens NMDA receptors on rapid, transient synaptic plasticity induced by cued nicotine reinstatement
No full textabstract: Nicotine use is an outstanding public health problem with associated social and economic consequences. Nicotine is an active alkaloid compound in tobacco and is recognized as a psychoactive drug. Preclinically, nicotine addiction and relapse can be modeled using a self-administration-reinstatement paradigm. Here, we used a nicotine self-administration and contingent cue-induced reinstatement model to examine rapid, transient synaptic plasticity (t-SP) induced by nicotine cue-triggered motivation. Although preliminary, treatment with the NMDA GluN2B subunit antagonist, ifenprodil, reduced reinstated nicotine seeking, and increased the percentage of spines with smaller head diameters. Thus, future studies are needed to fully parse out the role of NAcore GluN2B receptors in cued nicotine seeking and t-SP
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