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Transplantacija hondrocita u regeneraciji zglobne hrskavice
No full textChondrocytes transplantation in articular cartilage regeneration combines new and recent surgical and scientific advancements in cell therapy which is used to treat acute or overuse injuries of the articular cartilage. This surgical technique is called Autologous Chondrocyte Implantation (ACI) and has been performed, studied and improved over the last thirty years.
Autologous Chondrocyte Implantation is done by harvesting chondrocytes from a healthy area of the cartilage, then the chondrocytes are cultured in a laboratory, before being implanted again in the area of the injured cartilage. ACI is a surgical procedure that mainly targets the repair and regeneration of the articular cartilage of the knee joint.
This procedure can be performed with three slightly different modifications known as three generations. While first generation includes placing a periosteal cover over the defect area of cartilage to house the autologous chondrocytes, second generation uses a collagen membrane as a cover instead of the periosteal cover from the first generation. The third generation is based on biomaterials in which the autologous chondrocytes are embedded before being implanted to the area of the defect.
ACI is the topic of many studies which try to conclude how does this technique fit in the world of articular cartilage surgery, meaning how does this procedure compete with other different available procedures. First, studies were being done to measure the short and mid-term effectiveness of the surgery while later as the different generations emerged studies focused on challenging them against one another. Finally, and still on-going, ACI is being tested and studied in the long-term post-surgery period, to measure the success and the incidence of osteoarthritis as well as preserved function of the joint.
ACI is an expensive option for the patients and also requires them to be actively and highly involved in the long process of physical therapy and rehabilitation. It was concluded at this point that ACI is an effective technique both in the short and mid-term periods as well as the long-term periods post-surgery. Many of the patients that were studied reported excellent or good outcomes and this is also supported with the data provided by clinical scoring methods and imaging done during this studies.Transplantacija hondrocita u regeneraciji zglobne hrskavice kombinira novija kirurška i znanstvena dostignuća u staničnoj terapiji koja se koristi za liječenje akutnih ili kroničnih ozljeda zglobne hrskavice. Ovaj kirurška tehnika naziva se autologna transplantacija hondrocita (eng. autologous chondrocyte implantation – ACI) te se izvodi, proučava i poboljšava posljednjih trideset godina.
Metoda autologne transplantacije hondrocita podrazumijeva uzimanje hondrocita iz zdravog područja hrskavice, njihovo obrađivanje i umnožavanje u laboratoriju te ponovnu implantaciju u područje ozlijeđene hrskavice. Cilj autologne transplantacije hondrocita je oporavak i regeneracija zglobne hrskavice koljena.
Ova se metoda može izvesti s tri različite modifikacije, poznatije kao generacije. Dok prva generacija obuhvaća postavljanje periostalnog presadka preko oštećenog područja hrskavice za smještaj autolognih hondrocita, druga generacija kao presadak koristi kolagenu membranu kao pokrov umjesto periostalnog presadka iz prve generacije.Treća generacija koristi biomaterijale u koje su autologni hondrociti dodani prije implantacije u oštećeno područje
Mnoge studije pokušavaju uklopiti ACI metodu u svijet kirurgije zglobne hrskavice, odnosno usporediti je s drugim različitim dostupnim postupcima. Prvo su se studije radile kako bi se izmjerila kratkoročna i srednjoročna učinkovitost operacije, dok su se kasnije, s pojavom različitih generacija, studije usredotočile na njihovu međusobnu usporedbu. Još uvijek su u tijeku studije koje testiraju i proučavaju ACI u dugotrajnom postoperativnom razdoblju kako bi se izmjerila uspješnost i učestalost pojave osteoartritisa te očuvala funkcija zgloba. Studije su došle do zaključka da je ACI učinkovita metoda kako u kratkoročnom, tako i u srednjoročnom te dugotrajnom postoperativnom razdoblju.
Uz to što je skupa opcija za pacijente, ACI također zahtijeva od pacijenata da budu aktivno uključeni u dugi proces fizikalne terapije i rehabilitacije. Međutim, mnogi od pacijenata koji su sudjelovali u ispitivanjima pokazuju izvrsne ili dobre ishode, što je također potkrijepljeno podacima dobivenim kliničkim metodama bodovanja i snimanjima učinjenim tijekom ovih studija
Transplantacija hondrocita u regeneraciji zglobne hrskavice
No full textChondrocytes transplantation in articular cartilage regeneration combines new and recent surgical and scientific advancements in cell therapy which is used to treat acute or overuse injuries of the articular cartilage. This surgical technique is called Autologous Chondrocyte Implantation (ACI) and has been performed, studied and improved over the last thirty years.
Autologous Chondrocyte Implantation is done by harvesting chondrocytes from a healthy area of the cartilage, then the chondrocytes are cultured in a laboratory, before being implanted again in the area of the injured cartilage. ACI is a surgical procedure that mainly targets the repair and regeneration of the articular cartilage of the knee joint.
This procedure can be performed with three slightly different modifications known as three generations. While first generation includes placing a periosteal cover over the defect area of cartilage to house the autologous chondrocytes, second generation uses a collagen membrane as a cover instead of the periosteal cover from the first generation. The third generation is based on biomaterials in which the autologous chondrocytes are embedded before being implanted to the area of the defect.
ACI is the topic of many studies which try to conclude how does this technique fit in the world of articular cartilage surgery, meaning how does this procedure compete with other different available procedures. First, studies were being done to measure the short and mid-term effectiveness of the surgery while later as the different generations emerged studies focused on challenging them against one another. Finally, and still on-going, ACI is being tested and studied in the long-term post-surgery period, to measure the success and the incidence of osteoarthritis as well as preserved function of the joint.
ACI is an expensive option for the patients and also requires them to be actively and highly involved in the long process of physical therapy and rehabilitation. It was concluded at this point that ACI is an effective technique both in the short and mid-term periods as well as the long-term periods post-surgery. Many of the patients that were studied reported excellent or good outcomes and this is also supported with the data provided by clinical scoring methods and imaging done during this studies.Transplantacija hondrocita u regeneraciji zglobne hrskavice kombinira novija kirurška i znanstvena dostignuća u staničnoj terapiji koja se koristi za liječenje akutnih ili kroničnih ozljeda zglobne hrskavice. Ovaj kirurška tehnika naziva se autologna transplantacija hondrocita (eng. autologous chondrocyte implantation – ACI) te se izvodi, proučava i poboljšava posljednjih trideset godina.
Metoda autologne transplantacije hondrocita podrazumijeva uzimanje hondrocita iz zdravog područja hrskavice, njihovo obrađivanje i umnožavanje u laboratoriju te ponovnu implantaciju u područje ozlijeđene hrskavice. Cilj autologne transplantacije hondrocita je oporavak i regeneracija zglobne hrskavice koljena.
Ova se metoda može izvesti s tri različite modifikacije, poznatije kao generacije. Dok prva generacija obuhvaća postavljanje periostalnog presadka preko oštećenog područja hrskavice za smještaj autolognih hondrocita, druga generacija kao presadak koristi kolagenu membranu kao pokrov umjesto periostalnog presadka iz prve generacije.Treća generacija koristi biomaterijale u koje su autologni hondrociti dodani prije implantacije u oštećeno područje
Mnoge studije pokušavaju uklopiti ACI metodu u svijet kirurgije zglobne hrskavice, odnosno usporediti je s drugim različitim dostupnim postupcima. Prvo su se studije radile kako bi se izmjerila kratkoročna i srednjoročna učinkovitost operacije, dok su se kasnije, s pojavom različitih generacija, studije usredotočile na njihovu međusobnu usporedbu. Još uvijek su u tijeku studije koje testiraju i proučavaju ACI u dugotrajnom postoperativnom razdoblju kako bi se izmjerila uspješnost i učestalost pojave osteoartritisa te očuvala funkcija zgloba. Studije su došle do zaključka da je ACI učinkovita metoda kako u kratkoročnom, tako i u srednjoročnom te dugotrajnom postoperativnom razdoblju.
Uz to što je skupa opcija za pacijente, ACI također zahtijeva od pacijenata da budu aktivno uključeni u dugi proces fizikalne terapije i rehabilitacije. Međutim, mnogi od pacijenata koji su sudjelovali u ispitivanjima pokazuju izvrsne ili dobre ishode, što je također potkrijepljeno podacima dobivenim kliničkim metodama bodovanja i snimanjima učinjenim tijekom ovih studija
Transplantacija hondrocita u regeneraciji zglobne hrskavice
No full textChondrocytes transplantation in articular cartilage regeneration combines new and recent surgical and scientific advancements in cell therapy which is used to treat acute or overuse injuries of the articular cartilage. This surgical technique is called Autologous Chondrocyte Implantation (ACI) and has been performed, studied and improved over the last thirty years.
Autologous Chondrocyte Implantation is done by harvesting chondrocytes from a healthy area of the cartilage, then the chondrocytes are cultured in a laboratory, before being implanted again in the area of the injured cartilage. ACI is a surgical procedure that mainly targets the repair and regeneration of the articular cartilage of the knee joint.
This procedure can be performed with three slightly different modifications known as three generations. While first generation includes placing a periosteal cover over the defect area of cartilage to house the autologous chondrocytes, second generation uses a collagen membrane as a cover instead of the periosteal cover from the first generation. The third generation is based on biomaterials in which the autologous chondrocytes are embedded before being implanted to the area of the defect.
ACI is the topic of many studies which try to conclude how does this technique fit in the world of articular cartilage surgery, meaning how does this procedure compete with other different available procedures. First, studies were being done to measure the short and mid-term effectiveness of the surgery while later as the different generations emerged studies focused on challenging them against one another. Finally, and still on-going, ACI is being tested and studied in the long-term post-surgery period, to measure the success and the incidence of osteoarthritis as well as preserved function of the joint.
ACI is an expensive option for the patients and also requires them to be actively and highly involved in the long process of physical therapy and rehabilitation. It was concluded at this point that ACI is an effective technique both in the short and mid-term periods as well as the long-term periods post-surgery. Many of the patients that were studied reported excellent or good outcomes and this is also supported with the data provided by clinical scoring methods and imaging done during this studies.Transplantacija hondrocita u regeneraciji zglobne hrskavice kombinira novija kirurška i znanstvena dostignuća u staničnoj terapiji koja se koristi za liječenje akutnih ili kroničnih ozljeda zglobne hrskavice. Ovaj kirurška tehnika naziva se autologna transplantacija hondrocita (eng. autologous chondrocyte implantation – ACI) te se izvodi, proučava i poboljšava posljednjih trideset godina.
Metoda autologne transplantacije hondrocita podrazumijeva uzimanje hondrocita iz zdravog područja hrskavice, njihovo obrađivanje i umnožavanje u laboratoriju te ponovnu implantaciju u područje ozlijeđene hrskavice. Cilj autologne transplantacije hondrocita je oporavak i regeneracija zglobne hrskavice koljena.
Ova se metoda može izvesti s tri različite modifikacije, poznatije kao generacije. Dok prva generacija obuhvaća postavljanje periostalnog presadka preko oštećenog područja hrskavice za smještaj autolognih hondrocita, druga generacija kao presadak koristi kolagenu membranu kao pokrov umjesto periostalnog presadka iz prve generacije.Treća generacija koristi biomaterijale u koje su autologni hondrociti dodani prije implantacije u oštećeno područje
Mnoge studije pokušavaju uklopiti ACI metodu u svijet kirurgije zglobne hrskavice, odnosno usporediti je s drugim različitim dostupnim postupcima. Prvo su se studije radile kako bi se izmjerila kratkoročna i srednjoročna učinkovitost operacije, dok su se kasnije, s pojavom različitih generacija, studije usredotočile na njihovu međusobnu usporedbu. Još uvijek su u tijeku studije koje testiraju i proučavaju ACI u dugotrajnom postoperativnom razdoblju kako bi se izmjerila uspješnost i učestalost pojave osteoartritisa te očuvala funkcija zgloba. Studije su došle do zaključka da je ACI učinkovita metoda kako u kratkoročnom, tako i u srednjoročnom te dugotrajnom postoperativnom razdoblju.
Uz to što je skupa opcija za pacijente, ACI također zahtijeva od pacijenata da budu aktivno uključeni u dugi proces fizikalne terapije i rehabilitacije. Međutim, mnogi od pacijenata koji su sudjelovali u ispitivanjima pokazuju izvrsne ili dobre ishode, što je također potkrijepljeno podacima dobivenim kliničkim metodama bodovanja i snimanjima učinjenim tijekom ovih studija
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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