1,720,956 research outputs found
Chemotherapy with cisplatin and paclitaxel in locally advanced cervical cancer:has this regimen still a role as neoadjuvant setting?
No full textAIM: Neoadjuvant chemotherapy represents a promising alternative to concomitant
chemo-radiation therapy in locally advanced cervical cancer patients. The aim of
this study was the evaluation of pathologic response rates, toxicity and
predictors of response in locally advanced cervical cancer patients treated with
neoadjuvant cisplatin and paclitaxel followed by radical surgery.
METHODS: Fourteen patients with stage IB2 to IIB cervical cancer received three
cycles of cisplatin 75 mg/m2 and paclitaxel 175 mg/m2 intravenously every three
weeks followed by radical hysterectomy and bilateral pelvic lymphadenectomy.
Toxicity, pathologic response and predictors of response were evaluated.
RESULTS: Chemotherapy related toxicities we-re as follows: alopecia 100%,
asthenia 35.7%; nausea and vomiting 14.3%; paclitaxel hypersensitivity 7.1%,
neutropenia 7.1%. Optimal, partial and no pathologic response was achieved in
21.4%, 64.3% and 14.2% of the patients, respectively. Based on lack of pathologic
risk factors, 43% of the patients did not receive any adjuvant radiotherapy.
Better response rates were obtained in patients with stage IIB, tumor diameter <5
cm, Hb >12 g/dL and SCC antigen <1.5 mg/dL. None of these variables reached
statistical significance.
CONCLUSION: Neoadjuvant chemotherapy with cisplatin and paclitaxel in locally
advanced cervical cancer appeared to be well-tolerated. Even though the TIP
regimen has been shown to be more effective than the TP regimen in randomized
controlled prospective trial, the TP regimen remains a reasonable alternative in
those patients in whom the TIP regimen is considered or shown to be too toxic
Endometrial carcinoma during tamoxifen therapy. A case report [Adenocarcinoma dell'endometrio insorto durante terapia con tamoxifene: Descrizione di un caso clinico.]
No full textTamoxifen is a non-steroid estrogenic antagonist, used in post-surgical therapy of breast cancer. It interferes with endocrinous promotion of breast cancer. Tamoxifen could determine endometrial, even carcinomatous, alterations. The case of a postmenopausal patient surgically treated for breast cancer and successively treated with tamoxifen (20 mg/die), is reported. She underwent ultrasonographic and hysterosonographic endometrial evaluation and finally a hysterectomy with bilateral annessiectomy. This case seems to confirm tamoxifen possible carcinogenical effects on the endometrium
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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