1,720,960 research outputs found
Circadian temperature rhythm in intact, sham operated, gonadectomized rats.
No full textThirty-six CS rats (18 females and 18 males) have been studied: 22 gonadectomized (11 males and 11 females), 6 sham operated (3 males and 3 females) and 8 intact rats (4 males and 4 females). Three series of rectal temperature measurements have been performed: in the first one the animals were housed under strictly usual environment conditions (as far as the housing and lighting regimen was concerned); in the second one the animals were housed in metabolic cages in LD 12:12; in the third one the animals were housed in metabolic cages in DD. The mesor of temperature rhythm was always lower in ovariectomized than in intact rats, and always higher in castrated than in intact rats. Z9
Circadian temporal structure evaluated by automatic monitoring.
No full textA few aspects of the circadian time structure were evaluated in a young healthy woman, with a special reference to arterial pressure and body temperature. Both parameters were estimated by the use of automatic equipments. The present study evidences the importance and the advantages of autorhythmometry (which should be applied in every instance, but can not be omitted when measuring arterial pressure) and automatic monitoring (which warrants an excellent reproducibility of measurements). Z9
Circadian temperature rhythm in intact, sham operated, gonadectomized rats
No full textThirty-six CS rats (18 females and 18 males) have been studied: 22 gonadectomized (11 males and 11 females), 6 sham operated (3 males and 3 females) and 8 intact rats (4 males and 4 females). Three series of rectal temperature measurements have been performed: in the first one the animals were housed under strictly usual environment conditions (as far as the housing and lighting regimen was concerned); in the second one the animals were housed in metabolic cages in LD 12:12; in the third one the animals were housed in metabolic cages in DD. The mesor of temperature rhythm was always lower in ovariectomized than in intact rats, and always higher in castrated than in intact rats
Circadian rhythm of rectal temperature in young and adult rats under different conditions of food access.
No full textThe circadian rhythm of rectal temperature has been evaluated in young (1-month old) and adult (9 month old) female Wistar rats. The animals were housed in metabolic cages in LD 12:12 having food in powder and tap water ad libitum. The single cosinor analysis showed high statistical significance (at least p less than 0.01) in order to circadian rhythm of rectal temperature. The comparisons of the mean cosinor evaluations of circadian rhythm in the 2 differently aged groups do not show significantly different parameters for a 95% of confidence. Two more groups of animals, of the same age, strain, sex and environmental conditions, have been studied. These rats had food admittance in the first 4 h of the dark span (1200.1600) only. In this case too, no significant difference has been evidenced between young and adult rats in any parameters of circadian rhythm for a 95% of confidence. Therefore the 2 pools of animals (young and adult one together because of the already demonstrated lack of difference between the 2 groups) in ad libitum and restricted feeding regimen have been compared. No significant difference has been shown between the 2 groups regarding mesor, while Hotelling's test showed significant differences for amplitude and acrophase. Z9
"Zeus" a new oral anticoagulant therapy dosing algorithm: A cohort study.
No full textAbstract
The demand for oral anticoagulant therapy (OAT) has constantly increased during the last ten years with an extended use of computer assistance. Many mathematical algorithms have been projected to suggest doses and time to next visit for patients on OAT. We designed a new algorithm: “Zeus”.
A “before-after” study was planned to compare the efficacy and safety of this algorithm dosing OAT with manual dosage decided by the same expert physicians according to the target of International Normalized Ratio (INR). The study analysed data of 1876 patients managed with each of the two modalities for eight months, with an interval of two years between them.
The aim was to verify the increased quality of therapy by time spent in INR target and efficiency and safety of Zeus algorithm. Time in therapeutic range (TTR) was significantly (p<0.0001) higher during the algorithm dosing period in comparison with the TTR during manual management period (62.3% vs 50.3%). The number of PT/INR tests above 5 was significantly (p<0.001) reduced by algorithm suggested prescriptions in comparison with manual those (254 vs 537 times). The anticoagulant drug amount prescribed according to the algorithm suggestions was significantly (p<0.0001) lower than that of the manual method. The number of clinical events observed in patients during the algorithm management time was significantly (p<0.05) lower than that in those managed with the manual dosage.
This study confirms the clinical utility of the computer-assisted OAT and shows the efficacy and safety of the Zeus algorithm
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Circadian rhythm of rectal temperature in young and adult rats under different conditions of food access
No full textThe circadian rhythm of rectal temperature has been evaluated in young (1-month old) and adult (9 month old) female Wistar rats. The animals were housed in metabolic cages in LD 12:12 having food in powder and tap water ad libitum. The single cosinor analysis showed high statistical significance (at least p less than 0.01) in order to circadian rhythm of rectal temperature. The comparisons of the mean cosinor evaluations of circadian rhythm in the 2 differently aged groups do not show significantly different parameters for a 95% of confidence. Two more groups of animals, of the same age, strain, sex and environmental conditions, have been studied. These rats had food admittance in the first 4 h of the dark span (1200.1600) only. In this case too, no significant difference has been evidenced between young and adult rats in any parameters of circadian rhythm for a 95% of confidence. Therefore the 2 pools of animals (young and adult one together because of the already demonstrated lack of difference between the 2 groups) in ad libitum and restricted feeding regimen have been compared. No significant difference has been shown between the 2 groups regarding mesor, while Hotelling's test showed significant differences for amplitude and acrophase
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