1,720,958 research outputs found
Formulation Development, Optimization, and Characterization of Primaquine Loaded Lipid Based Nanocarriers for Liver Targeting
Full text linkMalaria is a mosquito-borne disease caused by unicellular eukaryotic parasite of genus Plasmodium. Since ancient times, it has been affecting human populations and still is considered as one of the deadliest diseases with the highest rates of morbidity and mortality. Malaria is the disease, most common in African and Asian regions and the rate of mortality varies from 0.3% to 2.2% on global level with 11% to 30% in tropical regions of the world. Several efforts are being made to control malaria which includes various attempts to eradicate the vectors of mosquitoes, develop effective vaccines, and new anti-malarial drugs. The parasites of malaria have exhibited resistance to some extent with nearly every antimalarial drug currently available and drugs in use are associated with serious side effects. Primaquine (PQ) was introduced in 1950 and it is an only 8-aminoquinoline being used as an antimalarial medicine till in 2018 tafenoquine was registered. Primaquine is an 8-aminoquilnoline antimalarial drug, that is widely used for the treatment of malaria as it provides a radical cure for the complete elimination of hypnozoites from the liver. The use of PQ is restricted to patients with glucose 6-phosphate dehydrogenase deficiency because of the severe dose related severe hemolytic side-effects. It has been approved by the FDA in the year 1952 and is considered as a radical cure for malaria. The mechanism of action of PQ is unclear however, in the recent times it has been studied that hydrogen peroxide that is produced from the metabolites of PQ is known to kill the active and dormant stages of the plasmodium parasitic species. PQ is a tissue schizonticide that also destroys the ex-erythrocytes thus preventing the relapse and recrudescence. A promising strategy to overcome the problems associated with PQ in the patients with G6PD deficiency is to develop a suitable drug carrier system. The objective of the present research was to develop and optimize the lipid nanocarriers as oral drug delivery systems for liver targetting, encapsulating PQ into the nanolipid carriers and reducing the exposure to erythrocytes leading to improved malarial chemotherapy. The purpose of the study is also to evaluate the physicochemical properties of the lipid based delivery systems
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
R12. Preparation and characterization of ligand attached new 8-aminoquinoline derivative loaded nanostructured lipid carriers for liver targeting
Full text linkCorresponding author (Pharmaceutics and Drug delivery): Samir Senapati, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1011/thumbnail.jp
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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