12 research outputs found
The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: A clinical trial study
No full textBackground: Osteoporosis affects quality of life (QoL) and may lead to depression in women. The purpose of this study was to evaluate the effects of zoledronic acid (ZA) treatment on depression and QoL in women with postmenopausal osteoporosis (PO). Materials and Methods: A total of 88 newly diagnosed women with PO were included in this study. All patients were treated with once-yearly ZA (5 mg). A QoL questionnaire from the European Foundation for Osteoporosis and Beck Depression Inventory were given to patients at baseline and at 12 months. The results for baseline and post - 12th month were compared, and bone mineral density (BMD) levels were compared. Results: The consumption of once-yearly ZA (5 mg) treatment increases BMD at levels of lumbers 1–4 (P = 0.026), total Hip T score's P value is same as femoral neck (P: 0,033). ZA 5 mg treatment also improved QoL (P = 0.001) and reduced depression (P = 0.001). Conclusion: ZA treatment increases BMD levels and QoL while reducing depression. Once-yearly ZA (5 mg) may be considered for postmenopausal women as a first-line treatment
Marine-Lenhart syndrome with papillary thyroid carcinoma
No full textGraves′ disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves′ thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves′ disease and AFTN. Total thyroidectomy was performed. The hyperfunctioning nodule with centrally hypoactive foci detected by technetium-99m thyroid scanning was histologically diagnosed as papillary thyroid carcinoma that was 2.5 cm in diameter. We report the presence of papillary thyroid carcinoma within AFTN in patients with Marine-Lenhart syndrome, which has not been reported so far
Caffeic acid phenethyl ester and vitamin E moderates IL-1 beta and IL-6 in bleomycin-induced pulmonary fibrosis in rats
No full textThe aim of this study was to investigate the effects of Caffeic acid phenethyl ester (CAPE), which has been demonstrated to have anti-inflammatory, antiproliferative, anticancerogenic, and antioxidant effects, and vitamin E on IL-1 beta and IL-6 in bleomycin-induced (BLM-induced) pulmonary fibrosis in rats. Thirty-two Sprague-Dawley rats were divided randomly into four groups as untreated control, bleomycin, bleomycin + CAPE, and bleomycin + vitamin E groups. At the end of the treatment, blood IL-1 beta and IL-6 levels were quantified. Bleomycin application to the rats resulted in a significant increase in the cytokine levels as compared to the controls. Administration of CAPE and vitamin E prevented the increase of blood IL-1 beta and IL-6 levels compared to the rats treated with bleomycin alone. Data presented here suggest that CAPE and vitamin E play a protective and moderator role against BLM-induced lung injuries by decreasing the primary inflammatory cytokines, such as IL-1 beta and IL-6. (c) 2006 Elsevier Inc. All rights reserved
Left ventricular diastolic function and circadian variation of blood pressure in essential hypertension.
No full textThe purpose of this prospective study was to determine the relationship between circadian blood pressure and left ventricular diastolic function in essential hypertension. The study population included 25 patients aged 56 +/- 18 years with non-dipper hypertension and 25 age- and sex-matched patients with dipper hypertension. They underwent conventional Doppler echocardiography and color tissue Doppler from apical 4- and 2-chamber views. In non-dipper patients, diastolic left ventricular function was reduced significantly. The transmitral E wave decreased (0.55 +/- 0.2 vs 0.62 +/- 0.2 m/s, P < 0.05), the transmitral A wave increased (0.77 +/- 0.1 vs 0.70 +/- 0.1 m/s, P < 0.01), the transmitral E/A ratio decreased (0.78 +/- 0.1 vs 0.86 +/- 0.2, P < 0.05), and the transmitral E-wave deceleration time increased in non-dipper patients (211 +/- 44 vs 196 +/- 42 ms, P < 0.05). The isovolumic relaxation time increased (112 +/- 15 vs 105 +/- 14 m/s, P < 0.05). The mean left ventricular myocardial velocities also differed significantly; the early diastolic velocity decreased (5.9 +/- 2. 1 vs 77 +/- 3.1 cm/s, P < 0.01), the late diastolic velocity increased (9.5 +/- 2.7 vs 8.7 +/- 1.6 cm/s, P < 0.05), and the E/A ratio decreased (0.68 +/- 0.55 vs 0.94 +/- 0.39, P < 0.01). These findings suggest that non-dipper hypertensive patients who have impaired left ventricular diastolic function should be identified early for careful follow-up and possible referral to a specialized center
Serum leptin, lipoprotein levels, and glucose homeostasis between national wrestlers and sedentary males
No full textAim: Leptin is an important controller of the size of fat stores by inhibiting appetite. In wrestling, fat metabolism is important not only for aerobic energy system, but also for weight control and weight loss before competition The aim of this study was to measure and compare the scrum leptin levels, glucose homeostasis, and serum lipoproteins between Turkish national wrestlers and sedentary male
Hypothalamic-pituitary-adrenal axis in patients with ankylosing spondylitis
No full textOBJECTIVE: To investigate the hypothalamic-pituitary-adrenal (HPA) axis via the insulin-tolerance test (ITT), standard-dose (250 mu g) ACTH test (SDT) and low-dose (1 mu g) ACTH test (LDT) in patients with ankylosing spondylitis (AS). DESIGN: The study group included 13 male patients with AS who were diagnosed according to the Modified New York criteria, and 8 healthy male subjects and was carried out at the Department of Physical Medicine and Rehabilitation, Erciyes University Medical School. ACTH stimulation tests were carried out by using 1 mu g and 250 mu g i.v. ACTH as a bolus injection, and blood samples were drawn at 0, 30 and 60 min. ITT was performed by using intravenous (i.v.) soluble insulin, and serum glucose and cortisol levels were measured before and after 30, 60, 90 and 120 min. All of the tests were performed consecutively with 3-day intervals, after an overnight fast. RESULTS: There were no significant differences between the patients with AS (mean age 36.9+/-6.7 years) and the healthy subjects (mean age 37.4 +/- 5.7 years) in terms of age. The basal cortisol levels in the AS group measured during LDT, SDT and ITT (556 +/- 204 nmol/l; 524 +/- 169 nmol/l; 418 +/-232 nmol/l, respectively) were comparable to the values of the control group (572 +/- 199 nmol/l; 520 +/- 182 nmol/l; 424 +/- 194 nmol/l, respectively). There were also no significant differences in peak cortisol responses between the two groups using LDT (patients 1025 +/- 339 nmol/l; controls 844 +/- 236 nmol/l), SDT (patients 1082 +/- 243 nmol/l; controls 1120 +/- 131 nmol/l) and ITT (patients 834 +/- 256 nmol/; controls 820 +/- 239 nmol/). CONCLUSION: In contrast with findings in other inflammatory diseases such as rheumatoid arthritis and polymyalgia rheumatica, the present data indicate that there is no apparent abnormality of the HPA axis activity in patients with AS
Lymphocyte subpopulations in Sheehan's syndrome
No full textPubMed: 22752347The role of autoimmunity in the development of Sheehan's syndrome is obscure. There are a limited number of studies investigating the immunological alterations accompanying Sheehan's Syndrome. Our objective was to evaluate lymphocyte subsets in these patients. We conducted a cross-sectional clinical study. Cytofluorometry was used for the immunophenotyping of peripheral blood leukocytes from patients with Sheehan's syndrome followed up in the endocrine clinic during 2005-2009. Fifteen consecutive patients (mean age 61.6 ± 11.3, range 34-75 years) and 25 healthy controls (mean age 56.7 ± 10.6, range 34-80 years) were included. There was no statistically significant difference between the groups in terms of mean age. The percentages of CD19 +, CD16+/56+, CD8+28-, ??TCR+, CD8+; the total lymphocyte counts; and the ratio of CD8+28-/CD8+28+ were similar (p > 0.05) between patients and controls. Whereas the leucocyte counts (p = 0.003), the percentage of CD3 + DR + (p < 0.001), CD8+28+ (p = 0.030), CD4+CD25 + (p = 0.007), the ratio of CD3 + DR+/CD3 (p < 0.001) were higher; the percentage of CD3 (p = 0.020), CD4 (p < 0.001) and the ratio of CD4/CD8 (p = 0.006) were lower in patients with Sheehan's syndrome compared to healthy controls. There was a positive correlation between the duration of illness and the percentage of CD3+DR+ (r = 0.53, p = 0.03) expression. Some peripheral lymphocyte cell subsets show marked variation in patients with Sheehan's syndrome in comparison to matched healthy subjects, which may have implications for altered immune regulation in these patients. High CD3 + DR + expression that correlates with the duration of illness in Sheehan's patients is suggestive of an ongoing inflammation accompanying the slow progression of pituitary dysfunction in Sheehan's syndrome. It is not clear if these cellular alterations contribute to the cause or consequence of pituitary deficiency in Sheehan's syndrome. © 2012 Springer Science+Business Media, LLC
Impaired longitudinal myocardial velocities in patients with growth hormone deficiency improves after hormone replacement therapy
No full textCardiac parameters in growth hormone (GH) deficiency and the effects of GH replacement treatment (GHRT) are still controversial. We investigated 19 adult patients (mean age: 45 +/- 10 years, 7 male), with GH deficiency before and after 12 months of GHRT. Twenty age- and sex-matched healthy individuals (mean age: 44 +/- 12 years, 9 male) were taken as a control group. All participants underwent echocardiography both before and after GHRT. The patients before GHRT and control subjects had similar left ventricular sizes and ejection fraction whereas patients before GHRT had impaired diastolic indices of left ventricle. Peak systolic annular velocity, which identifies myocardial longitudinal systolic function, was lower in patients before GHRT than in the control subjects (0.08 +/- 0.01 vs 0.10 +/- 0.02, P < .05) and improved after GHRT (0.09 +/- 0.03, P < .05). Adult-onset GH deficiency is associated with normal left ventricular sizes and preserved ejection fraction whereas longitudinal systolic function obtained by Doppler tissue imaging is deteriorated, which improves with 12 months of GHRT
