6 research outputs found
Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours
No full textBackground: PTEN is a tumour suppressor gene and well-known for being frequently mutated in several cancer types. Loss of immunogenicity can also be attributed to PTEN loss, because of its role in establishing the tumour microenvironment. Therefore, this study aimed to represent the link between PTEN and cGAS-STING activity, a key mediator of inflammation, in tumour samples of glioblastoma patients. Methods: Tumour samples of 36 glioblastoma patients were collected. After DNA isolation, all coding regions of PTEN were sequenced and analysed. PTEN expression status was also evaluated by qRT-PCR, western blot, and immunohistochemical methods. Interferon-stimulated gene expressions, cGAMP activity, CD8 infiltration, and Granzyme B expression levels were determined especially for the evaluation of cGAS-STING activity and immunogenicity. Results: Mutant PTEN patients had significantly lower PTEN expression, both at mRNA and protein levels. Decreased STING, IRF3, NF-KB1, and RELA mRNA expressions were also found in patients with mutant PTEN. Immunohistochemistry staining of PTEN displayed expressional loss in 38.1% of the patients. Besides, patients with PTEN loss had considerably lower amounts of IFNB and IFIT2 mRNA expressions. Furthermore, CD8 infiltration, cGAMP, and Granzyme B levels were reduced in the PTEN loss group. Conclusion: This study reveals the immunosuppressive effects of PTEN loss in glioblastoma tumours via the cGAS-STING pathway. Therefore, determining the PTEN status in tumours is of great importance, like in situations when considering the treatment of glioblastoma patients with immunotherapeutic agents. © 2024, The Author(s).TGA-2019-20329; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAKThis work was supported by the Ege University Scientific Research Projects Coordination (TGA-2019-20329). We would like to thank Timur Kose for his statistical advice.Open access funding provided by the Scientific and Technological Research Council of Türkiye (TÜBİTAK)
L166 Placer Dome (Eastern Goldfields) 2D Seismic Survey, WA, 2004
No full textMaintenance and Update Frequency: asNeededStatement: Lines 04PD-W1 to 04PD-W3
Line 1 at the Wallaby deposit is designed to test the strike extensions of the ENE striking 'Thets Fault' and other potential parallel and possibly mineralised structures. The surface trace of this fault is approximately 500m from the northern margin of the pit. Line 2 is to test the down plunge extension of the Wallaby orebody to the SSE of the pit. It is planned to reshoot either of these lines with the ANSIR minivib to experiment with a higher frequency seismic source that may provide higher resolution seismic images on the upper 1 to 2 km. ~10 km of seismic is planned over 2 lines with an additional 5 km of line subject to planning by Placer geologists.
Lines 04PD-KB1 to 04PD-KB3
Lines 1 and 3 at Kanowna Belle are to test strike extensions of the ENE striking 'Fitzroy Fault' and other potential parallel structures. The surface trace of this fault is through the northern margin of the pit. Line 2 is designed to test the dip direction of the NW-SE striking 'Kanowna Shear' which has its surface expression on the western side of the pit margin. This line also tests the down plunge extension of the orebody. It is anticipated that the geometry and depth of intrusive stocks and sills may also be imaged by these lines.
In addition line 1 will be reshot with the ANSIR minivib to experiment with a higher frequency seismic source that may provide higher resolution seismic images on the upper 1 to 2 km. ~16.5 km of seismic is planned over 3 lines.Trace Energy Services was contracted by the Australian National Seismic Imaging Resource (ANSIR) to conduct the WA seismic 2004 survey in the eastern & northern Goldfields region of Western Australia.<br/><br/>There were 148.59 km of 2D seismic reflection data recorded, 137.54 km over 29 traverses using Litton 315 Paystars and 11.05 km over 5 traverses using a single IVI Minivib as source. All lines were situated within the lease boundaries of gold mining companies, namely, Sons of Gwalia (Tarmoola & Gwalia) (L165), Placer Dome (Kanowna Belle, Wallaby, Granny Smith, Lancefield & Mt Morgans) (L166), Anglo Gold (Sunrise Dam) (L167) and Goldfields (St Ives at Kambalda) (L168)
Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome
No full text© 2024 Pérez-Martínez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Cellular senescence and low-grade inflammation favor the acceleration of aging. The liver is an essential metabolic organ because changes related to its function are related to age-related diseases. The objective of this study was to evaluate the effects of maraviroc (MVC) and/or rapamycin (RAPA) on liver tissue in an experimental model of frailty syndrome in mice, since MVC and RAPA are two molecules able to decrease CCR5 expression, which is overexpressed in patients with frailty. Methods: Eighty male homozygous IL10KO mice were randomly assigned to one of 4 groups (n = 20): i) IL10KO group; ii) MVC group, iii) RAPA group, and iv) MVC-RAPA group. Liver samples were analyzed. Gene expression quantification and western blotting were also performed. The proinflammatory cytokines IL-6 and IL-18 were decreased in MVC and MVC/RAPA groups, IL-12 was decreased in RAPA and MVC/RAPA groups and TNF-α was decreased in all therapeutic groups. P21 was decreased in RAPA and MVC/RAPA groups, Galactosidase beta-1, was also significantly reduced in all therapeutic groups, as were NF-kB1, NF-kB2 and STAT3. In all groups, mTOR and CCL5 were significantly reduced. CCR5 expression was decreased in the MVC and MVC/RAPA groups. Conclusion: MVC and RAPA may protect against some factors involved in liver aging. More studies will be necessary to verify their clinical applications.This study was partially supported by the Instituto de Salud Carlos III (ISCIII), M. Economía y Competitividad of Spain [Project Fondo de Investigaciones Sanitarias PI16/00127 (Strategic Action in Health 2013-2016)] (JRB). Co-funded by European Regional Development Fund (FEDER) "A way to make Europe", by the FEDER Funds, Call for aid to research groups for the development of research projects, technological development and innovation in the biomedical sector (FEDER Call -La Rioja; FRS-ABC.007) (LPM), and RTI2018-097455-B-I00 (MCIU/AEI/FEDER, EU) (AC); Cancer CYBER (CB16/12/00275) (AC).Peer reviewe
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No full textBattg f aln Alto Stat?*
TWENTY-FOURTH YEAR.
EIGHT PAGES.
PALO ALTO, CA_. MONDAY. MAY -a. 191&
EIGHT PAGES.
NO. i_6.
A SPARK OVEN
Let us place one in your home far 30
days—if not the best emu you bave ever
und—return it—we refund full purchase
price.
UZOAMatmwJffiBY
Palo Alto Hardware Co.
DAINTY PUMPS
New dressy models in this neat style of footwear
We have tl_m in the different leathers.
Tire Prices Reduced
The prices on Pennsylvania Vacuum
Cup Tires and on Pennsylvania Ebony
treads have been materially reduced.
Every automobilist can now afford to
equip his car with these justly famous tires.
Stanford Auto Co.
Phone P. A. 78
51 I Alma Street
SEEWOHORABIIIfOROOAL
PHONE 60
ALCO
TAXIS
Phone 138
Thomson's Taxi
Servlc
5 aad 7 ______« Touring Can' '
9 passenger 6 cylinder
Peerless Car
Boy s Book snd mr. 10 Per Cent
5 Taxi Books for*..50
SJC SERVICE
FIREWOOD
.'III.I. IT11IMW
BIO LOAD lull «4.
Dudfield Lumber Co.
Ysrd phon. 21. Mill phono 2_
- SBE CS ABOUT
TIMOTHY HOrECIS- LOTS
thb umvBRSrrr ukai.tv
COMPACT
Pslo Alto Stm Prssdsoo
MOTOR TRUCKS
KVnXITI'KK MOV1XG
Long and Short Ilaols.
Prompt and specti. attention
liven to baggage ord*r*.
PHONE OO
P-alo Alto Transfer and
Storage Company
111 OTROIJ-
|f.DESTRUCl
_*AMASE_
For Vacation Wear
LADIES'
SILK
COATS
and
SPORT
SKIRTS!
The Exclusive Kind
The Regent
I'HOM S FHKK OKUVKRIB*.
1'Inietalx. Holrproot aM
Heso tor mea, wonea aad child***.
Onaraet—d Ho** sschaaced at slor*.
Variety of Choruses In Operetta by
the Member* of th* Hif h School
Senior Clas*
JAXJ?
PHONE
15
AMillll TAXI SITHVICK
Oppo.ltc IMS**.
Autos For Hire
tnd Flv* Pa**_-_*jrr
ToHftag Cars and Taiia.
25c
First National
Bank
PALO ALTO
SENIOR OPERETTA
FRIDAY NIGHT
►. Carrinjton, Author of Operetta.
Pleased with Interpertation *t
Re hear**! Th u rsday
MURRAY STIRS
AT
Tbe Ann Arbor Track Men Triumph
over the Stanford Star* in tb*
Dual Meet
"Skin" Wilson of Stanford Breaks
Michigan MU* Record by Cover
ing Distance in 4:19
SENIOR PLAY
AT CASTILLEJA
Everymaiden in her Journey through
School" Presented by the
Graduating Class
Commencement Exercise* Will Be
Held Tomorrow Morning at 10
O'clock— at Graduates
The icnior class of Castilleja School
presented a four-act play tlii* morning
at it o'clock before a large gathering
of students and friends of the school
The name of the play was "Everymaiden in Her journey Through
School." Thc play wa* written hy the
senior class and was given in a very
pleasing and entertaining manner
Thc leading role of Everymaiden was
taken by Mils Sue Foater. who deserves much praise for her clever acting in her journey through school.
Thr play began with the freshman entering thc school and the four acta
showed her in every year of her high
school life.
The following was lhe cast of characters:
Prologue Florence Whit tier
Persons of the Dram*
Everymaiden Soe Foster
The Unnamed One. .Isabelle Fletcher
Authority Dorothy Cattell
Dreams Marie! Peringcr
Excitement Grace Morris
Grammar School .Gertrude Emmons
Creed Alice Malloy
Grouch Machelle Gunn
Kindness ..." > Helen Weaver
Mischief Mildred Miller
Mother Elsa McFarUnd
Pranks Helen Sharp
(Continued on Page Five)
J Miss Harker's School ♦
* Telephone 350 *
a All departments (including * ■,
a Monte**ori) open to visitors »
a daily from 9 lo tt. *,
* Special students received in •
J Mu*ic Ana and CraTt* Work, -
* and Domestic Science. *
0404**4*4*4*44**4*4
Devotees ot the theater, lovers ol
good music, trippers of the light fantastic loe—ar even the poor tired holiness man—will all find what they
want next Friday night at the Playhouse at 8:1 o'clock. Acting, singing .-nd dancing of the first order will
hold »way for a few short hours. The
senior class of the Palo Alto high
•chooi is to present their senior oper-1
ctta, "The Isle of Chance," another
of Otis Carrington's successful productions. From present indications
this nperrtta bids fair to rank smong
the beat productions ever presented
by the local-high school The danc-
Ing Jin! singing are the prominent
features, set off artistically by effects e stage arrangements. «
The chorus of twelve Follies,
dressed in *h(- mating costumes of
pink..M;te. yellow and green, with
their searchlights and balloons, offer
a splendid opportunity for spectacular effrci. The dancing ia remarkably good, owing to the fact thai
Mi.*. Helen Wcaterinan. Stanford,
ir* is coaching thia feature. The
main dancing is that of the Spirits of
Spring hy Emma Franklin and Louise
Kelly, but all of the choruses have a
number of dances. The three prinei
pal l-ollie*. Mary Willis Taff. Anila
'■"■!:■!-.11 antl Isabel Townley. have
sevf-ral stunts with lhe three main
sailor boys, Wills rd Sheldon. Herbert
Morse and Richard Ramsey.
The jolly chorus of sailors adds
merriment, while the chorus of shadows adds grotesquenets lo the effect.
There is much variety in costumes
and in thc little novelties and stir-
piisi *. which wilt be put in.
Mr. Carrington, the author, visilrd
rehear**! Thursday ctight and was
very well pleased with tlie interpretation of his operetta. He apoke especially of Jay Risling in the part of
"I'm a Grouch" and his shadow. "Despair," taken by Anne Tabex. who
look the part of "Loiika" in "Arms
and the Man.' He also praised Rob
l>nnran's interpret-!lion of the part of
(Continued on pai* eight >
Track athletes of Michigan'*! Ann
Arbor triumphed over the Iceland
Stanford University team on Ferry
Field Saturday. 71 points to 50 Four
Michigan records were broken, two
by California contestants and thc others by Michigan runner*.
Michigan's points resulted from
nine firsts, six seconds and eight
EDITORS WELL FED
ON ANNUAL TRIP
SUte Press Association Enjoys
Saturdsy Visit to Pctalums
snd SanU Ross
MRS. JOHNSON
PASSES AWAY
Mother of Dr. Edith Johnson and of
Profeaaor Alvin Johnson Dies
at Hospital
Captain Frederic 8. Murray
ihiril places, while thc visitor*, gathered their score on five firsts, seven
seconds and four thirds.- £aptain
Murray of Leland Stanford was the
individual star of the meet, scoring
thirteen points on one, first, twp seconds and two thirds. Captain How*
(Continued on Page Seven.)
Progressive and Proaperoua People Extend Hospitable Welcome)—Show Achievement*
By VV. H. KB1.IT
The California Pro** Association
enjoyed the hospitality or Petal ume
and Banta Roe* Saturday and after
■pending th* night at the Occidental
hotel In Banta Rosa continued their
leisurely way to Eureka, where they
arrived Sunday evening about ana-
down. The next flv* daya will be
spent seeing the sights of Humboldt
county. • region comparatively unexplored by the editor* because until a year ago there waa no railroad
running Into Boreka.
Tb* editorial csrunlon 1* made
this year In a epeclat train of four
Pullman sleepers, personally con-
I ducted hy the general passenger
agent of the Northwestern Pacific
railroad. Bvery effort Is being mad*
by the company to provide for th*
romfort and convenience of the
party.
Tbere are sbout n hundred in tb*
party, Many of the editor* bave
wives, mothers or daughter* wltb
them. Mr. and Mra. IT, W, filmklna
ar* representing Th* Times, A. P.
Helllsl* and his mother the Ban Ma-
teo News. Mr. snd Mr*. Will Make
th* GUrov Advocate. U B. Woodruff, formerly of th* Msyfleld Newt.
thc N»wman Record, Mr. snd Mr*.
A L, Henry the Mvarmore Herald.
It ls Interesting on the** trip* to
visit town* of about th* sam* else
a* i'alo Alto and not* how wall they
keep about tb* same pace In devel-
opment. and uniformly what an admirable population sll these California cities bsve.
Petal umn Hospitality
Th* elty of Pctaluma Is about the
■Is* or Palo Alto and tt 1* evidently
1 Recumtomed to entertaining large
parties of visitor*. The automobile*
were arranged side by aide along th*
full length or the railroad platform,
and the chairman or the day stat*d'
at the outset that there would be no
n*ce**lty to rrowd the automobtl>>i
(Continued on Page Two.)
THREE RILLED
UNANIMOUS VOTED 9. AT
favors bond; ISSUE!
The Funeral WUl Be Held Tomorrow
at * o'clock from Roller
ft Hapgood'a
Mrs. Marie 11 Johnson paisrd aw.iy
yesierday at thc Peninsula Hospilnl
■■ii- r a brief illness. The announce-'
ment will be received with torrow~hy
the many citizens who knew .and revered Mrs. Johnson during the yean
she had lived in Palo Alto.
Mrs. Johnson was born in Denmark
•nt Mnrch _*i. 1844* She came m
America in 1868 and located with her
husband in Nebraska. She remained
in tbat state until ioo_f, when the family moved to Palo Alto.
John Johnson, her husband, died
about one year ago. Four children
survive her. Dr. Edith E. Johnson of
Palo Alto, Professor Alvin I). Johnson s member of thc fsculty of Stanford University, and John A. Deirnp
and Harry T. Dcirup, attorney* of
Chico.
The funeral services will be held at
_ o'clock tomorrow afternoon from
Roller ft Ha (-good's mortuary chapel
jui'l the interment u ill be at the
Alt* Mesa cemetery.
Mrs. Johnson wat a woman of noble character and broad cnlture and
was deeply devoted to ber family. It
wss a 'pleasure to know one so sincere
and kindly and her friends mourn her
loss, one whom they so greatly loved
and cileemcd. Her passing came after
a life full of years nobly lived and thc
world has been the belter because nt
her having lived. This is a eoasola-
lion lhat will soften the grief of -t ■■■ ■
wltose lives will be the more lonely
now thai she is no longer with tbem.
Voters of the Stanford school district voted unanimously Saturday in
favor nf a $_t_-,ooo bond Issue for the
building of a new primary and grammar school building on the campus.
Thirly-one votes were east and not a
dissenting one. A site has been obtained from the Stanford University
board of trustees and thc entire *a*,-
000 will he used for a new building
and equipment.
J. J. Donovan of Oakland has been
retained by the Stanford bosrd of
education as architect. He drew the
plans for the polytechnic school in
Oakland. The school will be built
this summer.
George S. Walker, slate bCfllding
and loan commissioner and. a candidate for lhe Republican nomination
for congress for this district 10 oppose Representative E. A. Hayes, incumbent, was a Wat.onvillc visitor
Saturday in the interests of his candidacy.
An Automobile Filled with San Francisco Boys Crashes Through
Safety Gates—Hits Flyer
Kyc-Witness Says That the Crossing
Gate* Had Not Been Closed
la Time
Three youths, popular member*, of
the Columbia Park Roys' Club, were
killed snd another lies at the point of
death, while n fiflh escaped miraculously in an unusual automobile accident at Redwood City yesterday sfternoon.
-Clashing through lhe safety gates
of the Southern Pacific railway crossing, the automobile, carrying the lad*
on their way lo San Francisco "from
San Jose, ran into the southbound
Los Angeles flyer. The machine was
thrown through ihe air mo feet from
the point of collision and broken to
bits.
Th* Dead
Waller Ceresa, 'driver of thc e*rr
ao years old, 672A Cnpp street.'
(Continued on Page Two.)
MARQUEE
THEATER
Ideal Ventilation
Class A In Every Particular
T0NI0HT ONLY
Ho use Peters In
"The Hand of Peril"
From Arthur Stringer's tale 0. the -ante name. Five acts of extra*
ordinary scenes, a hundred thrill*
LATEST "PATHE WEEKLY1*.
AM'I.TS JOc—RIGHTO. 7:15. MATINEE H.9U—CIIIMlRKN. flc.
Tomorrow—Mae Marsh in "H oodoo Ann," Triangle Film
A study of Kuwait's monetary sector.
No full textThis study is concerned with the structure, development and working of the monetary sector in the State of Kuwait. Initially, the characteristics of the Kuwaiti economy are examined in order to put the monetary sector into perspective. It is shown that the Kuwaiti economy possesses the general characteristics of less developed economies together with some distinguishing properties. It is argued that since there exists no one-to-one relationship between government revenue and expenditure, the money supply, in the short run, tends to be insulated from the effect of the external balance. - The working of Kuwait's monetary sector is studied through the balance sheets of the Central Bank and commercial banks, and that leads on to an analysis of the money supply process. The definition of money is discussed, and it is argued on the basis of empirical evidence that the broad money supply is the most appropriate for the purpose of monetary control. Causality testing reveals a unidirectional effect from money to income, and the estimation of velocity equations indicates that financing economic development by monetary injections is inflationary in the short run. A multiplier reduced-form model reveals the viability of short-run monetary control in Kuwait, but it is argued that monetary policy has been ineffective in this respect. It is also postulated that the combination of interest and exchange rate policies gives rise to the recurring problem of capital outflows. A structural econometric model of the monetary sector shows that the equilibrium stock of money is determined by supply and demand factors, and that the control of banks' reserves can (in part) accomplish the objective of monetary control. The model also reveals that both monetary and fiscal actions affect real output and prices, but the former tend to be more powerful. It is recommended on the basis of this study that the Central Bank should be given greater autonomy in formulating and executing monetary policy, and that its research capabilities need to be improved. Urgent attention must be paid to developing financial markets and upgrading tools of monetary policy. Finally, It Is argued that the Ministry of Finance should take part in the control of money and credit by manipulating its deposits and, perhaps, adopting a simple constant change rule in government expenditure
