129 research outputs found
Rick Bragg, 1997 Harry M. and Edel Ayers Lecture Series 1
No full textAuthor Rick Bragg was featured at the Harry M. and Edel Ayers Lecture Series held November 19, 1997 on the 11th floor of the Houston Cole Library at Jacksonville State University.https://digitalcommons.jsu.edu/lib_ac_histimg_1990/1381/thumbnail.jp
Rick Bragg, 1997 Harry M. and Edel Ayers Lecture Series 2
No full textAuthor Rick Bragg was featured at the Harry M. and Edel Ayers Lecture Series held November 19, 1997 on the 11th floor of the Houston Cole Library at Jacksonville State University. Shown Rick Bragg chats with Opal A. Lovett after giving his speech.https://digitalcommons.jsu.edu/lib_ac_histimg_1990/1382/thumbnail.jp
EDEL: ENEA dosemeter for eye lens
No full textSince the publication of International Commission on Radiological Protection statement in 2011 on tissue reaction, eye lens radiation protection played an important role in exposed personnel dosimetry. For this reason, the Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) Individual Monitoring Service decided to study a prototype to fulfil specific requests (e.g. for survey in interventional department and intercomparisons). On the basis of such preliminary investigation, a new eye lens dosemeter was developed. The new dosemeter, named EDEL (ENEA Dosemeter for Eye Lens), was characterised in terms of Hp(3), the operational quantity related to eye lens monitoring. The investigation was performed experimentally and optimised using the Monte Carlo MCNP6 code. The new prototype was thought to fulfil two main requests: the reliability of the dosimetric data and the portability of the dosemeter itself. The new dosemeter will soon be supplied to the collaborating hospitals for workplace test measurements. © The Author 2015. Published by Oxford University Press. All rights reserved
Polyphony and the anxiety of influence in the fiction of Henry James
No full textJames's fiction, especially in the Middle Phase, centres
on the figure of the artist and is characterized by, the two
interrelated aspects which previous criticism has largely
overlooked: the Bakhtinian 'polyphonic' -creation of
'author-thinkers'; and the conflict between ephebes and
precursors, for which Harold-Bloom's concept of 'the-anxiety of
influence' is the most illuminating model. Polyphony is the
narrative mode, and influence is the intra-artistic, theme.
These, as the Introduction to the thesis makes clear, are
rehearsed in James's inaugural novel, Roderick Hudson. Rowland
Mallet is an author-thinker, and his failure is caused by
authorial limitations. His monologism -is impaired by his
mistaking empathy for the authorial sympathy. Likewise,
Hudson's failure does not arise from a mercurial temperament,
but from a polyphonic shortcoming: not possessing the power of
fiction to contain the fiction of power in, his mentor. And the
relationships among the three artists - Gloriani, Hudson and
Singleton - perfectly exemplify the Bloomian-theme. It is these
two concepts, polyphony and influence, which are the major
preoccupation in the Middle Phase; as, the works chosen
demonstrate. These are a novella, a novel, and a number of
short stories all of which have been unjustifiably neglected.
Chapter One, on The Aspern Papers, argues that Tina Bordereau,
far from being, the artless victim seen by many critics,
actually challenges and defeats the narrator by the very form
of her narrative. Her 'realist' discourse undermines his
language of 'romance', and shows up its internal unstability.
Chapter Two is an extensive study of the critical reception of
The Tragic Muse. The most common areas of critical attention
have been its contemporary topicality, its relation to previous
novels on similar themes, and the possible genealogy of Gabriel
Nash. Those have all missed the core of the work. - Chapter Three
demonstrates how polyphony and the anxiety of influence make
the novel what it really is. Influence arises from the
juxtaposition of, and the wrestling between, artistic ephebes
and their precursors (Nick and Nash,, Miriam and Madame Carre).
The dialogic quality defined by Bakhtin is crucial to the
proper, and even-handed, characterization of all, the conflicts
in the novel. And since most of James's tales in the eighties
and nineties -are about 'masters - and acolytes, the anxiety of
influence remains central. Chapter Four is a study of 'The
Author of Beltraffiol' and 'The Lesson of the Master'. Again the
characters' manipulations are a crucial focus in a way that
G6rard Genette's terminology helps to illuminate. The fact that
the ephebe is the author-thinker emphasizes the inextricability
of the Bakhtinian and the Bloomian in James. Just as
polyphony offers a different focus for explicating the poetics
of James's fiction; so the ephebal conflict provides the basis
for a fresh perception of James's own artistic struggle
Siegfried In The Interpretations Of The German Film Directors Of The Early 20th – Early 21st Century (Fritz Lang's "The Nibelungs" And Uli Edel`S "Ring Of The Nibelungs")
No full textFilm experts and art historians studied German cinema in detail, however, movies based on “The Song of the Nibelungs” as well as on the German and Scandinavian heroic epic have not yet been investigated by means of modern interdisciplinary approaches. The author pays attention to Siegfried, one of the most important heroes of the German and Scandinavian epic, according to Fritz Lang's (1890 – 1976) and Uli Edel`s (1947) interpretations, divided by almost a century (1924 and 2004). The author analyzes various means of expression: visuality, scenery, actor's performance, credits/dialogues. As far as the Lang's movie is concerned, he concludes that one can interpret the figure of Sigfried on two levels of interpretation. The first is the visual one which includes the actor's performance and the work of support staff (e.g. dress makers, set dressers). It describes him as an extraordinary strong hero. The second one is the semantic level which is formed of credits and music. It creates a myth about Siegfried as the national hero. In Edel's movie, the dialogues between heroes and actor's performance are used as the main means of expression. In Lang’s interpretation, Siegfried is described as the neo-romantic superhero, the person possessing a special force. Uli Edel’s Siegfried obtains dialectic nature – he is the prince, the king, and he is also the commoner; courageous soldier, dragon slayer, and obedient vassal, servant; son of Christian parents, pagan's stepson. The author assumes that Fritz Lang and Uli Edel reacted to inquiries of the time. In the 1920s, Germany suffered a difficult period between the two World Wars, the German people were oppressed by military reparations. Powerful Siegfried, as the national hero and embodiment of the German people, was urged to remind Germans of their great heroic past, to return their self-confidence to them. In our era of globalization and multiculturalism, the idea of association, peaceful co-existence of various ideas and religions was embodied in Siegfried.</jats:p
Fawcett, Edgar, 1885 August 15
No full textCopy extant? No record of it in Edel bindersPrivate, Anderson Galleries (NY), 3-4 September 1928: "Autograph Collection of a Late American Author" (#543
Organisational change and human resource management
No full textStrategic and operational changes are prevalent features of organisational life, pursued to ensure continued organisational success, and, in some cases, survival. It
is therefore concerning that many scholarly contributions on organisational change open with the ominous assertion that approximately 70 per cent of change initiatives fail (Balogun and Hope Hailey, 2004; Worley and Mohrman, 2014). Others recognise that, while on average this may be the case, rates of failure (and success) vary across different types of change (e.g. cultural versus structural change, see Smith, 2002).
The lack of consistent positive outcomes may be attributable to debate over the most appropriate way to implement change processes. This stems in part from the
overwhelming scale of the literature, illustrated in a 2015 search of MetaLib, which returned 1,057,005 results for ‘organisational change’. Debate also stems from the
different perspectives taken by authors. Some adopt an analytical approach, seeking to understand what organisations and individuals actually do. Others adopt more
prescriptive approaches, premised on guiding practitioners in implementing change (Burnes, 2009). Together, these factors have contributed to ‘the lack of a valid framework
of how to implement and manage organisational change’ (By, 2005: 370).
As the scale of the literature on change limits our capacity to comprehensively address all of the issues raised within it, the purpose of this chapter is threefold.
First, we introduce the nature of organisational change. Second, we explorethe four cornerstones of change: drivers, processes, agents and recipients (see Figure 15.1). These cornerstones can also be considered as the ‘why’, ‘how’
and ‘who’ of change – with the ‘who’ consisting of those responsible for making change happen, and those affected by it
The master and the bedpan: Henry James confronting trash in David Lodge’s author author (2004) and Joyce Carol Oates “The master at St. Bartholomew’s Hospital, 1914-1916” (2007)
No full textThis paper aims to discuss two recent biofictional narratives featuring Henry James as their protagonist – Lodge’s Author Author and Oates’s ‘The Master at St. Bartholomew's Hospital, 1914-1916’ – in relation to the theme of trash. Lodge and Oates both draw on Jamesian criticism (Forster, Wells, Edel) and his comments on the French Naturalists to present James as a snobbish author repelled by the sight and smell of bodily fluids, gangrenous flesh, excrements and ‘perverse’ sexual practices, which he has always refused to write about. However, human life is not only made by ‘the elegant flowering [of] civilization’, but also by what James deemed as unspeakable: in Oates’s short-story the fictional James realizes it while ministering to maimed soldiers at St. Bartholomew’s Hospital. ‘In all of the Master's prose, not one bedpan’, he sadly exclaims, acknowledging his refusal as an impairing inability. Thus, throughout the narration the Master is increasingly confined to silence while the third person narrator lingers on physiological acts and bodily trash. Similarly, in Lodge’s novel James is described as an old man farting, urinating and obliged to talk about them to his great discomfort. In both works there is ‘an infringement of the Jamesian propriety’ (see Hollinghurst) which interestingly unveils a task confronting the contemporary writer. These biofictional narratives are indeed a locus of anxiety and identification where discussing the challenges of writing. James’s questioning his own inabilities refracts Lodge and Oates’ urgency of finding a language that expresses all aspects of life, including trash
Visiting the Museum of the World with Henry James
No full textHenry James wrote novels in which his characters' actions are predetermined by their given natures and their environment. He understood "the psychological truth that a novel creates the greatest illusion of truth when it grows out of a personage's observations and perceptions." Therefore character is all-important in studying James' novels and because metaphors and allusions are an index to the way a character perceives the world, they must be regarded as clues given us by the author
(La función del ciclo celular en la auto-renovación y la pluripotencia de las células madre embrionarias humanas)
No full text[eng] Embryonic stem cells (ESC) are derived from the inner cell mass (ICM) of the blastocyst and have the capacity for unlimited proliferation while retaining their potential to differentiate into a wide variety of cell types when cultured in vitro. These properties have made of human embryonic stem cells (hESC) an excellent model on which to study the conditions required for differentiation into specific cell lineages, and consequently the possibility of transplanting specific cell types into damaged tissues.
The continued turn over of ESC while maintaining an undifferentiated state is dependent on unusual cell cycle properties. These unusual proliferative properties are responsible for the generation of tumours when these cells are injected into adult animals. Thus, the study of the unusual proliferative properties of hESC needs to be addressed if their potential is to be realized. To date, most studies of the cell cycle in hESC have been descriptive, lacking functional studies that reveal the mechanisms of how the cell cycle maintains pluripotency and self- renewal of hESC.
In this thesis we sought to understand the mechanisms of cell cycle control of hESC. We asked the question if a single cell cycle gene could regulate the self-renewal or pluripotency properties of hESC using a gain and loss of gene function strategy. We have identified that the protein expression of the p27Kip1 cell cycle inhibitor was low in human pluripotent cells, but its expression increased during differentiation together with changes in the cell cycle structure of pluripotent cells. By adopting a gain and loss of function strategy we increased or reduced its expression in undifferentiating conditions to define its functional role in self-renewal and pluripotency of Hesc, using undifferentiation conditions, overexpression of p27Kip1 in hESC lead to a G1 phase arrest with an enlarged and flattened hESC morphology and consequently loss of self-renewal ability. Loss of p27Kip1 caused an increase of self-renewal while maintaining an undifferentiated phenotype. Moreover, we have shown that a change in the balance of p27Kip1 levels in undifferentiated hESC affects expression of the mesoderm markers: BRACHYURY and TWIST. We have found that expression changes of TWIST are associated with the presence of p27Kip1 protein in the TWIST1 gene promoter.
The results presented in this thesis have interesting implications in stem cell biology. Firstly, these results define that the maintenance of p27Kip1 protein levels at a certain level is essential for self-renewal and pluripotency of hESC. Secondly, p27Kip1 is involved in the regulation of TWIST which is upregulated in several types of tumours and induces an epithelial-mesenchymal transition to facilitate tumor metastasis.[spa] Las células madre embrionarias humanas (conocidas como hESC por sus siglas en inglés de human embryonic stem cells) son derivadas de la masa celular interna de los blastocistos y poseen la capacidad para auto-renovarse ilimitadamente, reteniendo su potencial para diferenciarse hace una amplia variedad de tipos celulares (pluripotencia), cuando son cultivadas in vitro. Estas propiedades permiten el estudio de las condiciones requeridas para la diferenciación hacia linajes específicos y la posibilidad de trasplantar tipos celulares específicos en tejidos dañados.
El continuo recambio de las hESC al mismo tiempo que mantienen un estado de indiferenciación es dependiente de sus inusuales propiedades proliferativas. El objetivo de esta tesis doctoral fue el estudio de los mecanismos de control del ciclo celular de las hESC. Nos preguntamos si una única proteína del ciclo celular podría regular las propiedades de auto-renovación o pluripotencia de las hESC. En esta tesis doctoral identificamos que la expresión proteica del inhibidor del ciclo celular p27Kip1 era baja en diversas líneas celulares humanas pluripotentes pero aumentó durante la diferenciación, al mismo tiempo que la estructura del ciclo celular cambió. Mediante una estrategia de ganancia y pérdida de función, aumentamos o reducimos la expresión de p27Kip1 a fin de definir su función en la auto-renovación y la pluripotencia de las hESC. En condiciones de indiferenciación, la sobreexpresión de p27Kip1 en las hESC resultó en un arresto del ciclo celular en fase G1 y un cambio hacia una morfología más grande y aplanada, y consiguiente pérdida de la propiedad de auto-renovación. La pérdida de p27Kip1 causó un aumento de la auto-renovación manteniendo un fenotipo indiferenciado.
También, hemos demostrado que un cambio en la expresión de p27Kip1 en hESC indiferenciadas afecta la expresión de los reguladores de mesodermo: BRACHYURY y TWIST. Además, hemos descubierto que los cambios en la expresión de TWIST están asociados con la presencia de la proteína p27Kip1 en el promotor de TWIST1.
Estos resultados definen que los niveles de expresión de p27Kip1 son críticos para la auto-renovación y la pluripotencia de las hESC y sugieren una función para p27Kip1 en el control de la transición de epitelio a mesénquima
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