1,721,124 research outputs found
Human blood and bird egg proteins identified in the red paint covering a 1,000-year-old gold mask from Peru
No full textDDA data was generated using a orbitrap elite mass spectrometer form Thermo in November 2020 . Digested peptides were injected into the orbitrap mass spectrometer, a CID fragmentation was promoted.Raw data was generated by Thermo Xcalibur Software 1.05.51.0.
PEAKS 8.5 software was used to process the data
Metabolomics data for: Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
No full textThese data support the paper "Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells". We have investigated the mechanism(s) by which chronic hyperglycaemia and diabetes lead to impaired β-cell metabolism and if this is linked to activation of mTORC1. We show that a glycolytic metabolite downstream of glucokinase and upstream of GAPDH mediates the effects of diabetes and chronic hyperglycemia on β-cell metabolism. This occurs, in part, through marked upregulation of mTORC1, which leads to changes in metabolic gene expression, oxidative phosphorylation and insulin secretion. AMPK is concomitantly downregulated. In addition, diabetes dramatically inhibits the activity of GAPDH and PDH, which impairs both glycolytic metabolism and entry into the TCA cycle. Our results support the idea that progressive impairment of β-cell metabolism, induced by increasing hyperglycaemia, speeds T2D development, and suggest that reducing glycolysis at the level of glucokinase may slow this progression.
These data were produced from liquid chromatography-mass spectrometry analysis of: control and diabetic islets stimulated with 2 mM or 20 mM glucose (Fig. 3a,b & Suppl. Fig. 2), INS-1 (832/13) cells cultured for 48h with or without 5 μM koningic acid and subsequently stimulated with 2 mM or 20 mM glucose in the absence of koningic acid (Fig. 4a,b), and INS-1 cells cultured in 2 mM or 20 mM glucose (Suppl. Fig. 2). Anion-exchange chromatography-mass spectrometry (IC-MS) data were acquired on a Dionex IC-5000+ ion chromatography system hyphenated to a Thermo Fisher Scientific Q Exactive.
Data are .zip compressed to reduce file size. Data files are in .raw format and require Thermo Fisher Scientific Xcalibur software to analyse
Flannery o\u27connor\u27s theology viewed through the haze of the grotesque
No full textIn this thesis, by an analysis of the major works of Flannery O\u27Connor, I have examined the relationship between the author\u27s theology and her art, and by taking into consideration all significant critical points of view, the author\u27s published statments, I have attempted to come to some condlusions about Miss O\u27Connor\u27s peculiar vision, and more importantly, to determine whether her religious concerns in any way undercut her fiction
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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