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Glutamicibacter creatinolyticus strain LGCM 259 chromosome, complete genome
NCBI Reference Sequence: NZ_CP034412.1
The complete genome sequencing of G. creatinolyticus LGCM 259 was deposited with the
National Center for Biotechnology Information (NCBI) under accession number CP034412; BioProject:
PRJNA507728, BioSample: SAMN10502625, Assembly: GCF_006094275.1 and the same became NCBI
RefSeq sequence NZ_CP034412.1. https://www.ncbi.nlm.nih.gov/nuccore/1679400616.
LOCUS NZ_CP034412 3309128 bp DNA circular CON 08JUN2019
DEFINITION Glutamicibacter creatinolyticus strain LGCM 259 chromosome,
complete genome.
ACCESSION NZ_CP034412
VERSION NZ_CP034412.1
DBLINK BioProject: PRJNA224116
BioSample: SAMN10502625
Assembly: GCF_006094275.1
KEYWORDS RefSeq.
SOURCE Glutamicibacter creatinolyticus
ORGANISM Glutamicibacter creatinolyticus
Bacteria; Actinobacteria; Micrococcales; Micrococcaceae;
Glutamicibacter.
REFERENCE 1 (bases 1 to 3309128)
AUTHORS Santos,R.G., Silva,A.L., Seyffert,N., Castro,T.L.P., Attili,A.R.,
Rifici,C., Mazzullo,G., Brenig,B., Venanzi,F. and Azevedo,V.
TITLE Complete Genome Sequence of Glutamicibacter creatinolyticus strain
LGCM259,isolated from an abscess of a 12yearold
mare in Italy
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3309128)
AUTHORS Santos,R.G., Silva,A.L., Seyffert,N., Castro,T.L.P., Attili,A.R.,
Rifici,C., Mazzullo,G., Brenig,B., Venanzi,F. and Azevedo,V.
TITLE Direct Submission
JOURNAL Submitted (07DEC2018)
General Biology, UFMG, Av Antonio Carlos
6627, Pampulha, Belo Horizonte, Minhas Gerais 31270901,
Brazil
COMMENT REFSEQ INFORMATION: The reference sequence was derived from
CP034412.
The annotation was added by the NCBI Prokaryotic Genome Annotation
Pipeline (PGAP). Information about PGAP can be found here:
https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
Bacteria and source DNA available from GcLGCM259.
##GenomeAssemblyDataSTART##
Assembly Date :: OCT2018
Assembly Method :: SPAdes v. 3.9.1
Assembly Name :: GcLGCM259
Genome Representation :: Full
Expected Final Version :: Yes
Genome Coverage :: 286.0x
Sequencing Technology :: Illumina HiSeq
##GenomeAssemblyDataEND##
##GenomeAnnotationDataSTART##
Annotation Provider :: NCBI RefSeq
Annotation Date :: 06/07/2019 10:17:37
Annotation Pipeline :: NCBI Prokaryotic Genome
Annotation Pipeline (PGAP)
Annotation Method :: Bestplaced
reference protein
set; GeneMarkS2+
Annotation Software revision :: 4.8
Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA;
repeat_region
Genes (total) :: 3,035
CDSs (total) :: 2,962
Genes (coding) :: 2,882
CDSs (with protein) :: 2,882
Genes (RNA) :: 73
rRNAs :: 4, 4, 4 (5S, 16S, 23S)
complete rRNAs :: 4, 4, 4 (5S, 16S, 23S)
tRNAs :: 58
ncRNAs :: 3
Pseudo Genes (total) :: 80
CDSs (without protein) :: 80
Pseudo Genes (ambiguous residues) :: 0 of 80
Pseudo Genes (frameshifted) :: 31 of 80
Pseudo Genes (incomplete) :: 51 of 80
Pseudo Genes (internal stop) :: 6 of 80
GenBank
Due to the large size of this record, sequence and annotated features are not shown. Use the "Customize view" panel to change the display##GenomeAnnotationDataEND##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..3309128
/organism="Glutamicibacter creatinolyticus"
/mol_type="genomic DNA"
/strain="LGCM 259"
/isolation_source="abcess of a mare"
/host="horse"
/db_xref="taxon:162496"
/country="Italy"
/collection_date="2015"
CONTIG join(CP034412.1:1..3309128)
/
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Erythropoietin (EPO)-mediated mitogenic and anti-apoptotic effects involve all the cells expressing functional receptors for EPO (EPOR), as demonstrated by in vitro and in vivo studies. EPO shows pleiotropic effects and acts as an endogenous mediator of adaptive tissue response to metabolic stress protecting tissues from different injuries. Recently, the EPO/EPOR complex has been identified in several neoplastic cell lines and solid tumours. In this study, the authors investigated the mast cells (MCs) number, distribution and their immunoreactivity for EPOR in normal, dysplastic and neoplastic canine mammary gland. The results showed that MCs were more numerous in displastic glands compared with normal and neoplastic glands. As far as the EPOR immunoreactivity is concerned, we did not observe MCs reaction on cancer, in contrast with previously published data where epithelium of neoplastic gland showed an increase in EPOR expression along with the neoplastic progression. Overall, our results might be suggestive for MCs role in oncogenesis and offer new insight regarding to the expression of EPOR in mammary gland cancer in do
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