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    Le distanza legali

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    NULLITA', LA TRADIZIONE, IL NUOVO SISTEMA:DAL RISPETTO DELLA PAROLA DATA AL CONSENSO INFORMATO.

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    The paper discusses a subject which in recent years has gained a high profile due to the provenance of its regulations of reference, to the sectors in which it is developing and also due to its protagonists – special nullities or protective nullities. Such nullities rather often originate in the purview of the European Community and are then implemented into Italian law thus becoming available to the internal operator. After a brief outline of the characteristics distinctive of traditional nullity, an overview of the many specific regulations pinpoints the various sectors and domains of law where cases of invalidity occur that may be covered by the definition of special nullity or that can be more or less explicitly linked thereto. This recognition lays the foundations for ascertaining and analysing the underlying principles of these juridical cases and for setting forth the salient aspects: initial effectiveness or lack thereof of the invalidated contract, justification of the action of enforcing invalidity, necessary partiality and term of prescription. The results of the study made reveal a continuity of the discipline and a uniformity of the essential elements of the case that lead to the conviction that this is not a traditional juridical type nor can it be associated tout court with what is described in articles 1418 and following of the Italian Civil Code but it is, rather, a veritable set of autonomous dispositions which - although they may not be the exact opposite of the type of traditional nullity but are in a manner complementary to it – culminate in creating a veritable system

    Telemetry and computer processing of accelerometric data in cross country skiing

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    A telemetry system is described and a package of computer programs allowing the determination of the torso acceleration in cross country skiing. The acceleration components are given by two accelerometers mounted in quasibaricentric position in the antero-posterior vertical plane. One of the accelerometers measures also the gravity component, thus allowing the determination of the mean torso inclination. The signals from the two accelerometers are fed to a PCM telemetry system and recorded on analog tape after decoding at the receiving station. The package of Fortran programs allows: 1) AD conversion at 100 Hz to avoid aliasing in the useful spectral range, limited to 20 Hz; 2) calibration and automatic reduction of the noise due to transmission synchronization losses; 3) averaging, computation of the mean torso inclination and reconstruction of the vertical and horizontal acceleration components; 4) integration of the acceleration components to give speed and displacement components and thus potential and kinetic energy variations. A synchronization signal allows the comparison of the acceleration with the cinematographic analysis of the movement

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Thyroglobulin doubling time offers a better threshold than thyroglobulin level for selecting optimal candidates to undergo localizing [18F]FDG PET/CT in non-iodine avid differentiated thyroid carcinoma

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    Purpose: To investigate the potential role of serum thyroglobulin doubling time (TgDT) in predicting 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET/CT results in patients affected by differentiated thyroid carcinoma (DTC) who demonstrated a combination of positive Tg but a negative [131I] whole-body scan ([131I]-WBS). Materials and methods: Inclusion criteria were (1) prior [131I] treatment for DTC, (2) negative subsequent [131I]-WBS, (3) no interfering anti-Tg antibodies, (4) three consecutive Tg measurements under the thyroid hormone replacement therapy to calculate TgDT before 2-[18F]FDG PET/CT, and (5) at least 6 months of clinical and/or imaging follow-up to ascertain the diagnosis. Receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to identify the optimal cutoff point for the last stimulated Tg and TgDT prior to [18F]FDG PET/CT. Results: One hundred and thirteen patients were included. Seventy-four (65%) patients had positive [18F]FDG PET/CT for DTC recurrence, while the remaining 39 (35%) negative. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of [18F]FDG PET/CT were 92%, 94%, 97%, 87%, and 93%. Patients with positive [18F]FDG PET/CT had higher Tg and TgDT than those with negative PET/CT. ROC curve analysis revealed an optimal Tg cutoff of 19 ng/mL (sensitivity 78%, specificity 85%, AUC = 0.844) and TgDT of 2.5 years (sensitivity 93%, specificity 87%, AUC = 0.911). TgDT threshold of 2.5 years predicted significantly (p = 0.023) better than Tg level PET/CT results. Conclusions: The diagnostic performance of [18F]FDG PET/CT could be significantly improved when TgDT is less than or equal to 2.5 years, as compared with using the absolute Tg level

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Cardioprotective effect of angiotensin-converting enzyme inhibitors in patients with coronary artery disease

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    Clinical and experiments study with angiotensin-converting enzyme (ACE) inhibitors suggest that these agents may improve coronary artery disease by acting at multiple sites in the series of events leading to end-stage heart disease. These agents reduce blood pressure, improve prognosis and symptoms in patients with severe heart failure and in patients after acute myocardial infarction with left ventricular dysfunction. They are useful in the early, acute phase of myocardial infarction. More recently, ACE inhibitors have been shown to reduce in vitro vascular hypertrophy, to attenuate arteriosclerosis, and to maintain endothelium function. Whether these effects occur at clinical levels is still uncertain. The exciting clinical data have led to the proposal that alteration of ACE activity, particularly in tissue, is an important factor in development and progression of CAD. The ACE system is complex, with endocrine, paracrine, and autocrine effects. ACE is present in cardiac and vascular tissue. Therefore, the beneficial effects of ACE inhibitors can be classified as "cardio" and "vasculo" protective. This article summarizes a number of independent and complementary mechanisms pointing to a role of ACE and ACE inhibition in coronary artery disease
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