281 research outputs found
Classification of the Singularity Loci of m-n Fully-Parallel Manipulators
No full textSingularity analysis of fully-parallel manipulators (FPMs) produced a wide literature that tried to overcome the difficulty of algebraically calculating the determinant of general FPM’s Jacobian. An early work of this author addressed this problem by using Laplace expansion, and proposed an analytic expression of general FPM’s singularity locus which contains ten terms easy to compute and geometrically interpret. Such an expression is exploited here to classify the singu-larity loci of all the m-n FPM architectures
Development of Graves' hyperthyroidism during the early phase of pregnancy in a patient with pre-existing and long-standing Hashimoto's hypothyroidism.
No full textNeuroendocrine tumors secreting growth hormone-releasing hormone: Pathophysiological and clinical aspects.
No full textOct 10 Epub ahead of prin
Correction to: Ultra-late response (> 24 weeks) to anti-CGRP monoclonal antibodies in migraine: a multicenter, prospective, observational study (Journal of Neurology, (2024), 271, 5, (2434-2443), 10.1007/s00415-023-12103-4)
No full textIn the original version of this article, degree “ERT” of author Bonassi Stefano was incorrectly written as author in author group. Author group which previously read: Piero Barbanti1,2 · Cinzia Aurilia1 · Gabriella Egeo1 · Stefania Proietti3 · Florindo D’Onofrio4 · Paola Torelli5 · Marco Aguggia6 · Davide Bertuzzo6 · Cinzia Finocchi7 · Michele Trimboli8 · Sabina Cevoli9 · Giulia Fiorentini1 · Bianca Orlando1 · Maurizio Zucco10 · Laura Di Clemente10 · Ilaria Cetta11 · Bruno Colombo11 · Monica Laura Bandettini di Poggio12 · Valentina Favoni9 · Licia Grazzi13 · Antonio Salerno14 · Antonio Carnevale15 · Micaela Robotti16 · Fabio Frediani16 · Claudia Altamura17 · Massimo Filippi11 · Fabrizio Vernieri17 · Stefano Bonassi2,4 · ERT; for the Italian Migraine Registry study group. Should have read: Piero Barbanti1,2 · Cinzia Aurilia1 · Gabriella Egeo1 · Stefania Proietti3 · Florindo D’Onofrio4 · Paola Torelli5 · Marco Aguggia6 · Davide Bertuzzo6 · Cinzia Finocchi7 · Michele Trimboli8 · Sabina Cevoli9 · Giulia Fiorentini1 · Bianca Orlando1 · Maurizio Zucco10 · Laura Di Clemente10 · Ilaria Cetta11 · Bruno Colombo11 · Monica Laura Bandettini di Poggio12 · Valentina Favoni9 · Licia Grazzi13 · Antonio Salerno14 · Antonio Carnevale15 · Micaela Robotti16 · Fabio Frediani16 · Claudia Altamura17 · Massimo Filippi11 · Fabrizio Vernieri17 · Stefano Bonassi2,3 · for the Italian Migraine Registry study group. And affiliation details for author Stefano Bonassi were incorrectly given as 2San Raffaele University, Rome, Italy 4Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy 2San Raffaele University, Rome, Italy 4Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy but should have been: 2San Raffaele University, Rome, Italy 3Clinical and Molecular Epidemiology, IRCCS San Raffaele (not 2 and 4) 2San Raffaele University, Rome, Italy 3Clinical and Molecular Epidemiology, IRCCS San Raffaele (not 2 and 4
Diabetes in Cushing Disease
No full textPurpose of Review: This review focuses on the pathophysiological and clinical aspects of diabetes mellitus occurring in patients with Cushing disease (CD). Recent Findings: Insulin resistance and impairment in insulin secretion are both involved in the pathogenesis of glucocorticoid-induced diabetes. Correction of glucocorticoid excess does not always resolve abnormalities of glucose homeostasis, and correction of hyperglycaemia is specifically required. In fact, insulin resistance may persist even after correction of glucocorticoid excess and diabetes needs to be treated for long term. On the other hand, emerging drugs used in the treatment of CD, such as the novel somatostatin analog pasireotide, may have direct effects on glucose homeostasis regardless of control of cortisol excess. Summary: Diabetes mellitus is a frequent and early complication of CD with important diagnostic, prognostic and therapeutic implications. Specifically, diagnosis of CD in patients with diabetes may be difficult due to potential misinterpretation of markers of cortisol hypersecretion. Moreover, diabetes mellitus is often difficult to be controlled in CD requiring a careful and dedicated therapeutic approach. Finally, the coexistence of diabetes may influence the therapeutic decision making in CD, since drugs used in this setting may variably influence glucose homeostasis regardless of control of hypercortisolism
High prevalence of radiological vertebral fractures in adult patients with Ehlers-Danlos syndrome
No full textPrevious studies have reported an increased prevalence of osteoporosis in Ehlers–Danlos syndrome (EDS), but these were limited by a small number of patients and lack of information on fragility fractures. In this cross-sectional study, we evaluated the prevalence of radiological vertebral fractures (by quantitative morphometry) and bone mineral density (BMD, at lumbar spine, total hip and femoral neck by dual-energy X-ray absorptiometry) in 52 consecutive patients with EDS (10 males, 42 females; median age 41 years, range: 21–71; 12 with EDS classic type, 37 with EDS hypermobility type, 1 with classic vascular-like EDS, and 2 without specific classification) and 197 control subjects (163 females and 34 males; median age 49 years, range: 26–83) attending an outpatient bone clinic. EDS patients were also evaluated for back pain by numeric pain rating scale (NRS-11).Vertebral fractures were significantly more prevalent in EDS as compared to the control subjects (38.5% vs. 5.1%; p < 0.001) without significant differences in BMD at either skeletal sites. In EDS patients, the prevalence of vertebral fractures was not significantly (p = 0.72) different between classic and hypermobility types. BMD was not significantly different between fractured and non-fractured EDS patients either at lumbar spine (p = 0.14), total hip (p = 0.08), or femoral neck (p = 0.21). Severe back pain (≥ 7 NRS) was more frequent in EDS patients with vertebral fractures as compared to those without fractures (60% vs. 28%; p = 0.04). In conclusion, this is the first study showing high prevalence of vertebral fractures in a relatively large population of EDS patients. Vertebral fractures were associated with more severe back pain suggesting a potential involvement of skeletal fragility in determining poor quality of life. The lack of correlation between vertebral fractures and BMD is consistent with the hypothesis that bone quality may be impaired in EDS
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