135,398 research outputs found
D. Antonii Mazza Historiarum epitome
No full textCors. ; rom.[10], 160, [16] p., 1 c. di tav. : antip. calcogr.Segn.: a⁶ A-Y⁴Antip. calcogr. disegnata da Francesco Solimena e incisa da Jacques BlondeauOcchietto: D. Antonii Mazza Historiarum epitomeIniz. e fregi xil
«Se per amore i morti rinascessero»: Enzo Mazza, un (grande) poeta in ombra
No full textIllustrazione della produzione di Enzo Mazza e focalizzazione della sua poetica: principali linee tematiche, principali stilemi
Neurotensin as Modulator of Glutamatergic Signalling: Relevance in Neurodegenerative Diseases
No full textRationale: Neurotensin (NT) is a tridecapeptide widely distributed in mammalian brain, where acts as a neurotransmitter or neuromodulator of classical neurotransmitters, mainly through the activation of its receptor NTS1. Several in vitro and in vivo studies have demonstrated the existence of close interactions between NT and dopamine (DA) systems both in limbic and striatal brain regions (Nemeroff CB., 1985; Binder EB., 2001; Caceda R., 2006). Because of the involvement of an over-activation of DA system in the development of neurological disorders such as schizophrenia, psychosis and dyskinesia, a strong attention was given to the study of complex interactions between NTS1 and D2 dopamine receptor, highlighting the existence of receptor-receptor interaction, potential target for developing new anti-schizophrenic drugs (Ferraro L., 2007). In addition, neurochemical and biochemical data indicate that NT plays a crucial role in regulating glutamatergic transmission, probably inducing an amplification of NMDA receptor signalling, even at threshold concentrations (lOnM) (Antonelli T., 2004).
Results I: The neuromodulatory function of NT on glutamatergic signalling was studied in an in vitro model of primary cortical cultures, highlighting a dose-dependent effect (NT 0.1-300 nM) on glutamate release. In addition, NT show the ability to amplify the NMDA-induced (lOOnM) increase of glutamate release. The use of the NTS1 receptor antagonists, SR48692 (lOOnM) and the NMDA receptor antagonist MK-801 (l[iM), in combination with an effective concentration of NT, made possible to hypothesize that the mechanism involved could be an NTSl/NMDA receptor-receptor interaction (Antonelli T., 2004; Ferraro L., 2008) both at striatal and cortical level. It has been postulated that the accumulation of extracellular glutamate level and the consequent excessive activation of NMDA receptors (excitotoxic mechanism) contributes to neuronal death associated with chronic and acute neurodegenerative diseases (Olney JW., 1978). Since the data obtained to date suggest a NT-mediated strengthening on several glutamatergic functions in the central nervous system, our work was intended to deepen its possible involvement in glutamate-induced neurodegenerative mechanisms. The in vitro model of cerebral ischemia obtained by oxygen and glucose deprivation (OGD) showed a significant increase in extracellular levels of glutamate. In addition, significant alterations of biochemical and morphological parameters measured were observed. Increase the release of LDH, reduction of mitochondrial oxidative capacity (MTT levels), increased activity of caspase-3, increased number of apoptotic (fragmented) nuclei, increasead level of AN(+)/PI(-) immunoreactive cells and MAP-2 dendritic aggregations was measured 24 hours after the ischemic insult. The addition of NT (lOOnM) to the culture medium showed a significant increase in the OGD-induced changes, while cells pre-exposure to the NTS1 antagonist SR48692 (lOOnM) blocked the effect of both the neuropeptide and OGD exposure, alone or in combination. The results obtained with this in vitro model of cerebral ischemia, stress the involvement of NT activity in the eziopathogenesis of an acute neurodegenerative disease (Antonelli T., 2008).
Results II: At basal ganglia level, NT induces an amplification of glutamate release, probably through a NTS1/D2 antagonistic interaction. This phenomenon could contribute to the degeneration of dopaminergic nigro-striatal neurons by the means of an excitotoxic mechanism, pathogenetic feature of Parkinson's disease (PD). In this contex, experiments were conducted with the in vivo microdialysis technique at striatal and cortical level, anatomical areas notoriously involved in PD. The results obtained again showed that a, potential, NTS1/NMDA receptor-receptor interaction induces a glutamatergic signalling amplification. The observed increase in glutamate extracellular levels induced by treatment with NMDA (100 and 500 uM) and NT (lO nM), showed once again to be partially blocked by treatment with NT antagonist SR48692 (Ferraro L., 2008). Given the potential neuroprotective role played SR48692, successive studies in an vivo model of PD achieved through unilateral lesion of the nigro-striatalpathway with the neurotoxin 6-idroxydopamine (6-OHDA) were done. Three experimental groups were tested for the turning rotation behaviour and by a challenge with NMDA lOOuM: lesioned rats, rats exposed only to vehicle and lesioned rats treated with the neurotensinergic antagonist. The animals exposed to SR48692 have shown a significant recovery for both the parameter of turning behaviour and responsiveness to pharmacological challenge with NMDA (Ferraro L., 2008). The results obtained can lead to the hypothesis that the use of selective NTS1 receptor antagonists, in combination with conventional drug treatments, could provide a new terapeutic approach for chronic and acute neurodegenerative diseases treatment, such as cerebral ischemia and Parkinson's disease
Single-molecule analysis of transcription factor binding at transcription sites in live cells
No full textAlthough numerous live-cell measurements have shown that transcription factors (TFs) bind chromatin transiently, no measurements of transient binding have been reported at the endogenous response elements (REs) where transcription is normally induced. Here we show that at endogenous REs the transcriptionally productive specific binding of two TFs, p53 and the glucocorticoid receptor (GR), is transient. We also find that the transient residence times of GR at endogenous REs are roughly comparable to those at an artificial, multi-copy array of gene regulatory sites, supporting the use of multi-copy arrays for live-cell analysis of transcription. Finally, we find that at any moment only a small fraction of TF molecules are engaged in transcriptionally productive binding at endogenous REs. The small fraction of bound factors provides one explanation for gene bursting and it also indicates that REs may often be unoccupied, resulting in partial responses to transcriptional signals. OI Mazza, Davide/0000-0003-2776-414
The Dade group of a fusion system.
No full textWe define the notion of the Dade group of a fusion system and show that some of the gluing and detection results for Dade groups of finite p-groups due to Bouc and Thévenaz in [S. Bouc and J. Thévenaz. Gluing torsion endo-permutation modules. (Preprint.)], [S. Bouc and J. Thévenaz. A sectional characterization of the Dade group. J. Group Theory 11 (2008), 155–183.] extend to Dade groups of fusion systems
Parole Jelinek: Potere
No full textSul concetto di "potere" nell'opera teatrale di Elfriede Jelinek, premio Nobel 2004
Scontromeryx apulicus Mazza et Rustioni 2011
No full textScontromeryx apulicus (Mazza et Rustioni, 2011) Taxon A (partim)— Mazza & Rustioni 1999 (partim): p. 306, fig. 1 [SCT 76, SCT 88]. Hoplitomeryx apulicus Mazza & Rustioni, 2011 — Mazza & Rustioni 2011 (partim): p. 1304, 1318, 1330, figs 2, 3, 5, tables 1, 2 [SCT 76, SCT 88]. Holotype. Right hemimandible SCT 88 (Figure 2, D, E, F, in Mazza & Rustioni 2011). Paratypes. Hemimandibles SCT 76, SCT 88, (SCT 88 is indicated by Mazza & Rustioni (2011) as well as holotype as paratype). Revised diagnosis. Small species with brachyodont dentition. Mandible with slender and slightly sinuous ramus, with clearly convex ventral profile. In p 3 protoconid larger than metaconid, opposite in p 4; parastylid, hypoconid and entoconid well developed in lower premolars, paraconid present in unworn premolars; lower molars with swollen lingual enamel walls and with cuspids that remain isolated even in worn teeth; cheek teeth with occlusal surfaces markedly inclined outwards because of strong differential wear between inner and outer cuspids; labial conids markedly triangular and closely spaced, with flattened mesial walls; ectostylid very small in m 1, absent in m 2 and m 3; metastylids and postentocristids well developed but not protruding lingually; distal margin of hypoconulid fused, or not, to the entoconulid; enamel smooth; cingulum absent. Differential diagnosis. Larger than Scontromeryx falcidens according to Mazza & Rustioni (2011), but with Gargano specimens removed it is the smallest species. Differs from S. falcidens by a more elongated lower p 4 (L/ W ratio 1.7 vs 1.5) and having metastylids that are not lingually protruding. Differs from S. falcidens and S. minutus by having closely spaced labial conids of the lower molars and the very small ectostylid in m 1 and absence of an ectostylid in m 2 and m 3 and of a cingulum in lower molars. Differs from S. minutus by having a smooth labial enamel wall on its lower molars. Derivation of name. Not given by Mazza & Rustioni (2011). Likely after the Latin name for the present-day province of Puglia (southern Italy). Preservation and deposition. Soprintendenza Archeologica dell’Abruzzo (Chieti, central Italy). Type locality and horizon. Tortonian Scontrone Member of the Lithothamnium Limestone (Patacca et al. 2008; 41 ° 45 ' 15.54 'N, 14 °02' 13.14 ''E), outskirts of Scontrone, southern border of the National Park of Abruzzi, L’Aquila, central Italy. Description. See Mazza & Rustioni (2011). Additional characters shown by paratype revised after Mazza & Rustioni (2011). SCT 76 is a fragmentary right hemimandible with three molars (Mazza & Rustioni 1999, not mentioned in Mazza & Rustioni 2011). m 1 –m 2. occlusal surfaces considerably inclined outwards; inner cuspids maintain sharp and pointed for long, outer cuspids affected by relatively higher degrees of wear. m 3. distal margins of both hypoconulid and entoconulid either separated or fused towards the collar of the tooth. Measurements. See Table 2. Remark. An additional differential character was the long diastema in S. apulicus, but this diastema cannot be confirmed for the Scontrone specimens.Published as part of Van Der Geer, Alexandra A. E., 2014, Systematic revision of the family Hoplitomerycidae Leinders, 1984 (Artiodactyla: Cervoidea), with the description of a new genus and four new species, pp. 1-32 in Zootaxa 3847 (1) on page 17, DOI: 10.11646/zootaxa.3847.1.1, http://zenodo.org/record/28681
THIS FIERCE GEOMETRY:USES OF THE JUDEO-CHRISTIAN BIBLE IN THE ANTI-ABOLITIONIST AND ANTI-GAY RHETORIC OF THE UNITED STATES
No full textTHIS FIERCE GEOMETRY:USES OF THE JUDEO-CHRISTIAN BIBLEIN THE ANTI-ABOLITIONIST AND ANTI-GAY RHETORICOF THE UNITED STATESMichael J. Mazza, Ph.D.University of Pittsburgh, 2009This dissertation examines the citational use of the Judeo-Christian Bible in two sociopolitical debates within the United States: first, the debate over the abolition of slavery in the nineteenth century, and second, the contemporary debate over gay rights. This study incorporates two core theses. First, I argue that the contemporary religious right, in its anti-gay use of the Bible, is replicating the hermeneutical practices used by opponents of the abolitionist movement. My second thesis parallels the first: I argue that the contemporary activists who reclaim the Bible as a pro-gay instrument are standing in the same hermeneutical tradition as nineteenth-century Christian abolitionists. This study is thus about the acts of interpreting texts and putting those interpretations to use in the public sphere.The first chapter lays out the historical and conceptual groundwork for this study. Among the issues considered are the evolution of the biblical canon, the role of interpretive communities in biblical interpretation, and the matrix of human difference, privilege, and marginalization. The second chapter reviews more than thirty biblical passages used by anti-abolitionist activists in their public discourses. There is a comparative thrust to this chapter, because it juxtaposes this "slavemaster's Bible" with the biblical passages used in anti-gay discourse. The third chapter is a comparative analysis of the biblical hermeneutics practiced by nineteenth-century abolitionists and contemporary pro-gay thinkers. In this chapter I identify seven general strategies which these two groups hold in common as each engages the biblical text. The fourth and final chapter considers the possible connections that link the hermeneutics of the American abolitionist and gay rights movements to three other currents of thought: first, the ubuntu theology of Desmond Tutu; second, the minjung theology of South Korea; and third, the philosophy of hermeneutics developed by Hans-Georg Gadamer. The study ends with a brief coda, which considers some of the political and cultural events of 2009 in light of the dissertation's main ideas
The group of endotrivial modules for the symmetric and alternating groups.
No full textWe complete a classification of the groups of endotrivial modules for the modular group algebras of symmetric groups and alternating groups. We show that, for n ≥ p2, the torsion subgroup of the group of endotrivial modules for the symmetric groups is generated by the sign representation. The torsion subgroup is trivial for the alternating groups. The torsion-free part of the group is free abelian of rank 1 if n ≥ p2 + p and has rank 2 if p2 ≤ n < p2 + p. This completes the work begun earlier by Carlson, Mazza and Nakano
Rethinking chromatin accessibility: from compaction to dynamic interactions
No full text: The genome is traditionally divided into condensed heterochromatin and open euchromatin. However, recent findings challenge this binary classification and the notion that chromatin condensation solely governs the accessibility of transcription factors (TFs) and, consequently, gene expression. Instead, chromatin accessibility is emerging as a factor-specific property that is influenced by multiple determinants. These include the mobility of the chromatin fiber, the capacity of TFs to engage repeatedly with it through multivalent interactions, and the four-dimensional organization of its surrounding diffusible space. Unraveling the molecular and biophysical principles that render a genomic target truly accessible remains a significant challenge, but innovative methods for locally perturbing chromatin, coupled with microscopy techniques that offer single-molecule sensitivity, provide an exciting experimental playground to test new hypotheses
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