100,887 research outputs found
Im Angesicht des Chaos – Die Geschichte zweier US-amerikanischer Anwaltskanzleien, ihrer Gründer sowie ihres Erfolges
No full textNeuhaus T. Im Angesicht des Chaos – Die Geschichte zweier US-amerikanischer Anwaltskanzleien, ihrer Gründer sowie ihres Erfolges. In: Hutmacher F, Mayrhofer R, eds. Errungenschaften: Historische und psychologische Perspektiven auf eminente Leistungen. Lengerich: Pabst ; 2023
The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro
No full textCopyright © 2008 Elsevier Inc. All rights reserved.Dasatinib (BMS-354825) is a Src/ABL tyrosine kinase inhibitor currently approved for the treatment of chronic myeloid leukemia. Dasatinib has increased potency against ABL compared to the current therapy imatinib, and is effective in many cases where disease is resistant to imatinib. Dasatinib also inhibits many Src-family tyrosine kinases. We have demonstrated in this study that dasatinib is able to block the function of normal human T-lymphocytes in vitro at clinically relevant concentrations. T-cell functions including proliferation, activation and cytokine production were all uniformly inhibited in the presence of dasatinib. We also demonstrated inhibition of TCR signalling through Src-family kinase LCK, and predicted that inhibition of LCK and other kinases involved in T-cell signalling by dasatinib is responsible for the suppression of T-cell function. These findings raise the concern about potential T-cell inhibition in patients taking dasatinib, and suggest a possible application for the treatment of T-cell mediated immune disorders.Stephen Blake, Timothy P. Hughes, Graham Mayrhofer and A. Bruce Lyon
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Shake Well Before Use: Intuitive and Secure Pairing of Mobile Devices
No full textA challenge in facilitating spontaneous mobile interactions is to provide pairing methods that are both intuitive and secure. Simultaneous shaking is proposed as a novel and easy-to-use mechanism for pairing of small mobile devices. The underlying principle is to use common movement as a secret that the involved devices share for mutual authentication. We present two concrete methods, ShaVe and ShaCK, in which sensing and analysis of shaking movement is combined with cryptographic protocols for secure authentication. ShaVe is based on initial key exchange followed by exchange and comparison of sensor data for verification of key authenticity. ShaCK, in contrast, is based on matching features extracted from the sensor data to construct a cryptographic key. The classification algorithms used in our approach are shown to robustly separate simultaneous shaking of two devices from other concurrent movement of a pair of devices, with a false negative rate of under 12 percent. A user study confirms that the method is intuitive and easy to use, as users can shake devices in an arbitrary pattern
Molecular support for the recognition of the Mycoblastus fucatus group as the new genus Violella (Tephromelataceae, Lecanorales)
No full textThe crustose lichen genus Mycoblastus in the Northern Hemisphere includes eight recognized species sharing large, simple ascospores produced 1–2 per ascus in strongly pigmented biatorine apothecia. The monophyly of Mycoblastus and the relationship of its various species to Tephromelataceae have never been studied in detail. Data from ITS rDNA and the genes coding for translation elongation factor 1- and DNA replication licensing factormini-chromosome maintenance complex 7 support the distinctness of Mycoblastus s. str. from the core of the Tephromelataceae, but recover M. fucatus and an undescribed Asian species as strongly supported within the latter group. We propose accommodating these two species in a new genus, Violella, which is characterized by its brownish inner ascospore walls, Fucatus-violet hymenial pigment granules and secondary chemistry, and discuss the position of Violella relative to Calvitimela and Tephromela. We describe the new species Violella wangii T. Sprib. & Goffinet to accommodate a new species with roccellic acid from Bhutan, China, India and the Russian Far East. We also exclude Mycoblastus indicus Awasthi & Agarwal from the genus Mycoblastus and propose for it the new combination Malmidea indica (Awasthi & Agarwal) Hafellner & T. Sprib
Influence of Yttrium on the Thermal Stability of Ti-Al-N Thin Films
No full textTi(1-x)Al(x)N coated tools are commonly used in high-speed machining, where the cutting edge of an end-mill or insert is exposed to temperatures up to 1100 degrees C. Here, we investigate the effect of Yttrium addition on the thermal stability of Ti(1-x)Al(x)N coatings. Reactive DC magnetron sputtering of powder metallurgically prepared Ti(0.50)Al(0.50), Ti(0.49)Al(0.49)Y(0.02), and Ti(0.46)Al(0.46)Y(0.08) targets result in the formation of single-phase cubic (c) Ti(0.45)Al(0.55)N, binary cubic/wurtzite c/w-Ti(0.41)Al(0.57)Y(0.02)N and singe-phase w-Ti(0.38)Al(0.54)Y(0.08)N coatings. Using pulsed DC reactive magnetron sputtering for the Ti(0.49)Al(0.49)Y(0.02) target allows preparing single-phase c-Ti(0.46)Al(0.52)Y(0.02)N coatings. By employing thermal analyses in combination with X-ray diffraction and transmission electron microscopy investigations of as deposited and annealed (in He atmosphere) samples, we revealed that Y effectively retards the decomposition of the Ti(1-x-y)Al(x)Y(y)N solid-solution to higher temperatures and promotes the precipitation of c-TiN, c-YN, and w-AlN. Due to their different microstructure and morphology already in the as deposited state, the hardness of the coatings decreases from similar to 35 to 22 GPa with increasing Y-content and increasing wurtzite phase fraction. Highest peak hardness of similar to 38 GPa is obtained for the Y-free c-Ti(0.45)Al(0.55)N coating after annealing at T(a) = 950 degrees C, due to spinodal decomposition. After annealing above 1000 degrees C the highest hardness is obtained for the 2 mol % YN containing c-Ti(0.46)Al(0.52)Y(0.02)N coating with similar to 29 and 28 GPa for T(a) = 1150 and 1200 degrees C, respectively
Interfacial insight in multi-junction metal oxide photoanodes for water-splitting applications
No full textPhotoelectrochemical (PEC) properties of nanostructured hematite (Fe2O3) thin films prepared
using plasma-enhanced chemical vapor deposition (PE-CVD) were investigated against the
influence of processing parameters and post-synthesis heat-treatment procedures.Annealing at
high temperatures (> 500 °C) was found to substantially affect the micro-structure (grain
growth and densification) and electronic (interdiffusion at the film/substrate interface)
concomitantly manifested in an enhancement in the PEC behavior. The Sn impuritylevel in
hematite films was found to increase with the annealing temperature with highest values
achieved in samples heat-treated at 750 °C, due to the interdiffusion and substitution of Sn(IV)
species at Fe(III) sites. Sn:Fe2O3 films exhibited significantly high photocurrent density of
1.33 mAcm-2 at the water oxidation level of 1.23V vs. RHE. The diffusion of Sn ions into iron
oxide lattice altered the electronic properties of hematite films duetoelectron–donor behavior
of the dopants that was verified by X-ray photoelectron spectroscopy and secondary ion mass
spectroscopy (SIMS) analyses.Deposition of a thin overlayer of TiO2 (10 nm) on hematite films
by atomic layer deposition (ALD) was found to furthe rimprove the photocurrent density to
1.8 mAcm-2 at 1.23V vs.RHE. Ab-initio calculations on the effect of substitutional Sn(IV)
dopants in the Fe2O3 lattice on the electronic structure and the band alignment between
hematite and theTiO2 over layer revealed that Sn-dopants led to the generation of localized Fe
(II) centers augmenting then-type behavior of hematite.No effect of the Sn-dopingonthe
electrostatic potential was found on a macroscopic scale.However, the charge transfer from
the Sn-doping to the Fe(II) centers would cause high electric fields on the nanometer scale and
might hence play an important role in the efficient separation o felectron and holes.The
simulations showed that the hematite band edges are enclosed by the TiO2 band edges and
therefore electron depletion at the surface–liquid interface is enhanced.This might lead to
reduced recombination rates near the surface and consequently to increased photocurrents,
since the Fe2O3/TiO2 interface constitutes a barrier for hole transport
Heterotic T-fects, 6D SCFTs, and F-theory
No full textWe study the (1, 0) six-dimensional SCFTs living on defects of non-geometric heterotic backgrounds (T-fects) preserving a E7 × E8 subgroup of E8 × E8. These configurations can be dualized explicitly to F-theory on elliptic K3-fibered non-compact Calabi-Yau threefolds. We find that the majority of the resulting dual threefolds contain non-resolvable singularities. In those cases in which we can resolve the singularities we explicitly determine the SCFTs living on the defect. We find a form of duality in which distinct defects are described by the same IR fixed point. For instance, we find that a subclass of non-geometric defects are described by the SCFT arising from small heterotic instantons on ADE singularities
Ubiquity of non-geometry in heterotic compactifications
No full textWe study the effect of quantum corrections on heterotic compactifications on elliptic fibrations away from the stable degeneration limit, elaborating on a recent observation by Malmendier and Morrison. We show that already for the simplest nontrivial elliptic fibration the effect is quite dramatic: the I1 degeneration with trivial gauge background dynamically splits into two T-fects with monodromy around each T-fect being (conjugate to) T-duality along one of the legs of the T2. This implies that almost every elliptic heterotic compactification becomes a non-geometric T-fold away from the stable degeneration limit. We also point out a subtlety due to this non-geometric splitting at finite fiber size. It arises when determining, via heterotic/F-theory duality, the SCFTs associated to a small number of pointlike instantons probing heterotic ADE singularities. Along the way we resolve various puzzles in the literature
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
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