1,721,094 research outputs found
Regularized vortex approximation for 2D Euler equations with transport noise
Full text linkWe study a mean field approximation for the 2D Euler vorticity equation driven by a transport noise. We prove that the Euler equations can be approximated by interacting point vortices driven by a regularized Biot-Savart kernel and the same common noise. The approximation happens by sending the number of particles N to infinity and the regularization in the Biot-Savart kernel to 0, as a suitable function of N
Palisaded neutrophilic granulomatous dermatitis and its associations with autoimmune diseases
No full textPalisaded neutrophilic granulomatous dermatitis and its associations with autoimmune disease
Uniform approximation of 2D Navier-Stokes equations with vorticity creation by stochastic interacting particle systems
Full text linkWe consider a stochastic interacting particle system in a bounded domain with reflecting boundary, including creation of new particles on the boundary prescribed by a given source term. We show that such particle system approximates 2D Navier–Stokes equations in vorticity form and impermeable boundary, the creation of particles modeling vorticity creation at the boundary. Kernel smoothing, more specifically smoothing by means of the Neumann heat semigroup on the space domain, allows to establish uniform convergence of regularized empirical measures to (weak solutions of) Navier–Stokes equations
Overview of Atopic Dermatitis in Different Ethnic Groups
Full text linkAtopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent years, more attention has been placed on the heterogeneity of AD associated with multiple factors, including a patient’s ethnic background, resulting in an increasing body of clinical, genetic, epidemiologic, and immune-phenotypic evidence that delineates differences in AD among racial groups. Filaggrin (FLG) mutations, the strongest genetic risk factor for the development of AD, are detected in up to 50% of European and 27% of Asian AD patients, but very rarely in Africans. Th2 hyperactivation is a common attribute of all ethnic groups, though the Asian endotype of AD is also characterized by an increased Th17-mediated signal, whereas African Americans show a strong Th2/Th22 signature and an absence of Th1/Th17 skewing. In addition, the ethnic heterogeneity of AD may hold important therapeutic implications as a patient’s genetic predisposition may affect treatment response and, thereby, a tailored strategy that better targets the dominant immunologic pathways in each ethnic subgroup may be envisaged. Nevertheless, white patients with AD represent the largest ethnicity enrolled and tested in clinical trials and the most treated in a real-world setting, limiting investigations about safety and efficacy across different ethnicities. The purpose of this review is to describe the heterogeneity in the pathophysiology of AD across ethnicities and its potential therapeutic implications
Severe cutaneous aluminum reaction to quadrivalent human papillomavirus vaccine treated with cyclosporin
No full textThe quadrivalent human papillomavirus (HPV) vaccine contains capsid L1 proteins of HPV-6–11, -16 and -18, and 225 lg of aluminum hydroxyphosphate sulfate as adjuvant to potentiate the immune response.1 Aluminum may rarely induce foreign body reactions, which at times may be severe.2 A 24-year-old woman presented with a 11 cm 9 6 cm indurated plaque on the left deltoid area that developed 4 months after HPV vaccine injection
Lichen planopilaris coexisting with plaque psoriasis effectively treated with brodalumab
No full textLichen planopilaris coexisting with plaque psoriasis effectively treated with brodaluma
Acquired perforating dermatoses show increased levels of cutaneous advanced glycation end-products
No full textBackground Acquired perforating dermatoses (APDs) are characterized by transepidermal elimination of skin materials. Altered glycation of dermal components may be involved in pathogenesis. Aim To assess whether patients affected by APDs have increased levels of cutaneous advanced glycation end-products (AGEs). Methods A cross-sectional controlled study involving a total of 109 patients was conducted, enrolling 29 patients consecutively diagnosed with primary APDs [reactive perforating collagenosis (RPC), elastosis perforans serpiginosa (EPS), perforating folliculitis (PF) and Kyrle disease (KD)], 40 age- and sex-matched healthy controls (HCs) and 40 patients with mild atopic dermatitis (AD). The levels of cutaneous AGEs were measured using a validated fluorescence technique. Results The median skin autofluorescence value in patients with APDs was significantly higher [2.7 arbitrary units (AU), interquartile range (IQR) 1.9-3.9 AU] compared with HCs (1.8 AU, IQR 1.6-2.3 AU; P < 0.001) and patients with AD (2.1 AU, IQR 1.9-2.3 AU; P = 0.01). Median values were 3.5 AU (IQR 2.7-4.6 AU) for RPC, 1.83.5 AU (1.4-2.4 AU) for EPS, 3.1 AU (2.4-4.4 AU) for PF and 2.6 AU (2.3-3.1 AU) for KD. Conclusions Our results may suggest a possible physiopathological role of AGEs in the transepidermal elimination mechanisms involved in certain APDs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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