543 research outputs found

    "Caring Nothing for Sacrifice”: the Drama of Solitude in Edna O’Brien’s "Iphigenia2

    No full text
    This paper focuses on Edna O'Brien's adaptation of Euripides' Iphigenia in Aulis, concentrating on O'Brien's aesthetics and a shift away from the female-centredness of her earlier work

    Medical Ethics: An Excuse for Inefficiency?

    No full text
    The author maintains that the medical profession ignores the objective of a health care system--to maximize the health of the community with the resources available--in favor of maximizing the care of the individual patient. In terms of medical ethics this results in an apparent conflict between the individual values of virtue and duty and the social value of the common good. Mooney proposes certain changes in Britain's National Health Service which, while preserving clinical freedom, would lead to incorporation of the value of the common good into medical ethics. (KIE abstract

    Lawyering at the Extremes: The Representation of Tom Mooney, 1916-1939

    Get PDF
    This article explores the complex and often strained relationship between Tom Mooney, the famous labor radical who was framed for a bombing murder, and his lawyers over the course of the 23-year long battle to gain his freedom. The author uses the lawyers’ archives to explore the intense difficulties that arise between a client who believes the legal system is hopelessly corrupt and his lawyers who hope to free their client and redeem the justice system at the same time. While sympathetic to Tom Mooney and the lawyers, Roiphe concludes that an independent legal profession struggling to negotiate its obligation to the client and the system is a fundamental aspect of the American democratic system

    Two-loop Sudakov form factor in ABJM

    No full text
    This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited

    Claus Prodehl and Walter D. Mooney : Exploring the earth’s crust: history and results of controlled-source seismology [Book review]

    No full text
    Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Marine Geophysical Research 35 (2014): 419-421, doi:10.1007/s11001-014-9221-0.Prodehl and Mooney have done an impressive service to the community in providing this compendium of controlled-­‐source seismic studies of the earth's crust carried out to 2005. It is a remarkable piece of work. The book will be a valuable resource for students and researches in earth sciences for many years to come.2015-04-2

    Introduction to the themed issue - Corporate power : agency, communication, influence and social policy

    No full text
    This paper introduces this themed issue of Critical Social Policy on the question of corporate power. Corporate power is recognized as an important agent in social policy making and delivery. However, to date there has been comparatively little attention to the crucial role that lobbying and corporate 'spin' play in helping to shape policy making contexts. This special issue of Critical Social Policy is concerned to bring such issues to the mainstream of social policy analysis. It is argued here that the rise of spin and public relations is a key feature of neoliberalism in the past two decades. These have worked to reshape policy making, resulting in pronounced changes in the content and process of policy making and it is argued that these have tended to marginalize or undermine democratic processes

    Spectral tuning of ultraviolet cone pigments: An interhelical lock mechanism

    No full text
    Ultraviolet (UV) cone pigments can provide insights into the molecular evolution of vertebrate vision since they are nearer to ancestral pigments than the dim-light rod photoreceptor rhodopsin. While visible-absorbing pigments contain an 11-cis retinyl chromophore with a protonated Schiff-base (PSB11), UV pigments uniquely contain an unprotonated Schiff-base (USB11). Upon F86Y mutation in model UV pigments, both the USB11 and PSB11 forms of the chromophore are found to coexist at physiological pH. The origin of this intriguing equilibrium remains to be understood at the molecular level. Here, we address this phenomenon and the role of the USB11 environment in spectral tuning by combining mutagenesis studies with spectroscopic (UV-vis) and theoretical [DFT-QM/MM (SORCI+Q//B3LYP/6-31G(d): Amber96)] analysis. We compare structural models of the wild-type (WT), F86Y, S90A and S90C mutants of Siberian hamster ultraviolet (SHUV) cone pigment to explore structural rearrangements that stabilize USB11 over PSB11. We find that the PSB11 forms upon F86Y mutation and is stabilized by an "inter-helical lock" (IHL) established by hydrogen-bonding networks between transmembrane (TM) helices TM6, TM2, and TM3 (including water w2c and amino acid residues Y265, F86Y, G117, S118, A114, and E113). The findings implicate the involvement of the IHL in constraining the displacement of TM6, an essential component of the activation of rhodopsin, in the spectral tuning of UV pigments. © 2013 American Chemical Society

    Craig Miller, Carol Edison, Ute beader Fabian Jenks

    No full text
    Craig Miller, Carol Edison, Ute beader Fabian Jenk
    corecore