16 research outputs found
Influence of water on the electroanalytical behaviour of (K,Na)HSO4 eutectic melt. Characterization of Hg32+.
No full textErrata corrige, 69 (1979) Author Index, p. 3
L’esperienza del Piano Lauree Scientifiche nella formazione degli insegnanti
No full textIl capitolo discute il contributo che l'esperienza del Piano Lauree Scientifiche può fornire alla questione relativa a quali siano oggi, nell’ambito della formazione scientifico-tecnologica avanzata, gli obiettivi strategici per la formazione iniziale degli insegnanti. Ed esamina come una stretta integrazione fra sistema scolastico e sistema universitario, quale quella sperimentata e documentata dal Piano Lauree Scientifiche, costituisca una modalità di intervento importante per definire le migliori strategie da adottare nell’ambito della formazione iniziale degli insegnanti
Ivrea Geophysical Body (IGB) model geometry
No full textIvrea Geophysical Body (IGB) model geometry
Original publication: Scarponi et al. (2020), Geophys J Int, doi: 10.1093/gji/ggaa263
We here provide our reference density model for the Ivrea Geophysical Body (IGB), developed by means of 3D gravity data modelling. The IGB model is defined by a single crustal interface, extending across the study area.
The density contrast associated with the interface is +400 kg/m3.
Study area (latitude, longitude in degrees):
- min longitude: 7.5 E
- max longitude: 9.0 E
- min latitude: 45.4 N
- max latitude: 46.3 N
Study area lower left corner in latitude, longitude:
- 45.4 N, 7.5 E
This point is marked as a red circle in the presented figures, and it is used as the origin for the Cartesian reference frame in kilometres (x[km],y[km]).
Files' content:
- 3D_IGB_Model_Geometry.txt:
ASCII text file containing the model geometry in the format:
x[km], y[km], lon[deg], lat[deg], depth[km]
The Cartesian reference frame (x[km],y[km]) has its origin in the lower left corner of the study area and extends up to 800 km distance from the origin (the study area is extended on purpose during gravity modelling, to avoid edge effects). Here we report the complete model geometry as extracted from the modelling software (IGMAS+).
* The reader should focus only on the study area domain, where gravity data has been measured and modelled! *
- 3D_IGB_Reference_Model.fig:
MATLAB .fig format file showing a rotatable 3D view of the interface defining the IGB model geometry.
- 2D_IGB_CrossSections.png:
.png format picture showing East-West oriented vertical cross sections of the IGB model. The view is towards the South across the cross-sections.
For any question and/or discussion please contact the authors via email at: [email protected]
Best regards,
Matteo Scarponi and co-author
Longitudinal acoustic compliance and tagged particle susceptibility in liquid and supercooled glycerol
No full textBrillouin spectra of glycerol measured in the visible, ultraviolet and X-ray frequency regions allow us to reckon the imaginary part of acoustic compliance,J"(omega), over a broad frequency range from fraction of GHz to tens of THz. We observe that J"(omega) suitably mimic the shape of the tagged particle susceptibility, chi"(INS)(omega), measured by incoherent neutron spectra for both the liquid and supercooled states. The proportionality between these two quantities suggests a strict relationship between acoustic dissipation and generalized density of states. (C) 2010 Elsevier B.V. All rights reserved. [Comez, L.] Univ Perugia, IOM CNR, I-06123 Perugia, Italy; [Comez, L.; Paciaroni, A.; Scarponi, F.; Fioretto, D.] Univ Perugia, Dipartimento Fis, I-06123 Perugia, Italy; [Monaco, G.] European Synchrotron Radiat Facil, F-38043 Grenoble, France; [Masciovecchio, C.; Gessini, A.] Sincrotrone Trieste, I-34012 Basovizza Trieste, Italy; [Ruocco, G.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy Comez, L (reprint author), Univ Perugia, IOM CNR, I-06123 Perugia, Italy. [email protected] Ruocco, Giancarlo/A-6245-2010; paciaroni, alessandro/J-2447-2012 Ruocco, Giancarlo/0000-0002-2762-9533; 34 1 1 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0022-3093 J NON-CRYST SOLIDS J. Non-Cryst. Solids JAN 15 2011 357 2 SI 515 517 10.1016/j.jnoncrysol.2010.05.096 3 Materials Science, Ceramics; Materials Science, Multidisciplinary Materials Science 725JK WOS:000287640800049 J Gregori, B; Papazachariadis, O; Farruggia, A; Accornero, N Gregori, Bruno; Papazachariadis, Odysseas; Farruggia, Alfonsa; Accornero, Neri A differential color flicker test for detecting acquired color vision impairment in multiple sclerosis and diabetic retinopathy JOURNAL OF THE NEUROLOGICAL SCIENCES English Article Critical fusion frequency; Flicker test; Color vision disorders; Optic neuritis; Retinopathy; Diabetes OPTIC NEURITIS; CONTRAST SENSITIVITY; MACULAR DEGENERATION; EVOKED-POTENTIALS; FUSION FREQUENCY; AGE; LUMINANCE; DISEASE; LOSSES; DISCRIMINATION Background: Optic neuritis related to multiple sclerosis and diabetic retinopathy are relatively selective postretinal and retinal vision disorders. Vision impairment in both conditions is reliably measured by testing critical fusion frequency (CFF). Methods: To examine color vision, we measured the CFF in response to red and blue stimuli, and tested CFF values in patients without evident vision impairment. To ensure that differences in CFF values in a given subject depended only on color perception we displayed red and blue flickering stimuli at equal luminance. CFF to red or blue stimuli were compared in patients with medical history of optic neuritis related to multiple sclerosis (post-retinal vision impairment), patients with diabetic retinopathy (retinal vision impairment) and healthy subjects. Results: The test procedure disclosed altered CFF values for red and blue stimuli in both groups of patients studied. The comparison between the two groups disclosed a prevalent CFF impairment for red stimuli in patients with optic neuritis related to multiple sclerosis and for blue stimuli in patients with diabetic retinopathy. Conclusions: The differential color flicker test appears highly accurate in detecting color vision impairment. Comparison of the two color CFFs differentiates retinal from post-retinal visual disorders. (c) 2010 Elsevier B.V. All rights reserved. [Papazachariadis, Odysseas] Univ Roma La Sapienza, Dept Physiol & Pharmacol, I-00185 Rome, Italy; [Gregori, Bruno; Papazachariadis, Odysseas; Farruggia, Alfonsa; Accornero, Neri] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy; [Gregori, Bruno] UO Neurol, Clin Nuova Itor, I-00158 Rome, Italy Papazachariadis, O (reprint author), Univ Roma La Sapienza, Dept Physiol & Pharmacol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. [email protected] 42 2 2 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0022-510X J NEUROL SCI J. Neurol. Sci. JAN 15 2011 300 1-2 130 134 10.1016/j.jns.2010.09.002 5 Clinical Neurology; Neurosciences Neurosciences & Neurology 714ZT WOS:000286850900024 J Bernabei, M; Moreno, AJ; Zaccarelli, E; Sciortino, F; Colmenero, J Bernabei, Marco; Moreno, Angel J.; Zaccarelli, Emanuela; Sciortino, Francesco; Colmenero, Juan From caging to Rouse dynamics in polymer melts with intramolecular barriers: A critical test of the mode coupling theory JOURNAL OF CHEMICAL PHYSICS English Article SPATIALLY HETEROGENEOUS DYNAMICS; GLASS-TRANSITION; SUPERCOOLED LIQUIDS; SIMULATION; RELAXATION; SCATTERING; ADSORPTION; CHAINS By means of computer simulations and solution of the equations of the mode coupling theory ( MCT), we investigate the role of the intramolecular barriers on several dynamic aspects of nonentangled polymers. The investigated dynamic range extends from the caging regime characteristic of glass-formers to the relaxation of the chain Rouse modes. We review our recent work on this question, provide new results, and critically discuss the limitations of the theory. Solutions of the MCT for the structural relaxation reproduce qualitative trends of simulations for weak and moderate barriers. However, a progressive discrepancy is revealed as the limit of stiff chains is approached. This disagreement does not seem related with dynamic heterogeneities, which indeed are not enhanced by increasing barrier strength. It is not connected either with the breakdown of the convolution approximation for three-point static correlations, which retains its validity for stiff chains. These findings suggest the need of an improvement of the MCT equations for polymer melts. Concerning the relaxation of the chain degrees of freedom, MCT provides a microscopic basis for time scales from chain reorientation down to the caging regime. It rationalizes, from first principles, the observed deviations from the Rouse model on increasing the barrier strength. These include anomalous scaling of relaxation times, long-time plateaux, and nonmonotonous wavelength dependence of the mode correlators. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3525147] [Moreno, Angel J.; Colmenero, Juan] Univ Basque Country, CSIC, Ctr Fis Mat, E-20018 San Sebastian, Spain; [Moreno, Angel J.; Colmenero, Juan] Mat Phys Ctr MPC, E-20018 San Sebastian, Spain; [Bernabei, Marco; Colmenero, Juan] Donostia Int Phys Ctr, E-20018 San Sebastian, Spain; [Zaccarelli, Emanuela; Sciortino, Francesco] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Zaccarelli, Emanuela; Sciortino, Francesco] Univ Roma La Sapienza, CNR ISC, I-00185 Rome, Italy; [Colmenero, Juan] Univ Basque Country, Dept Fis Mat, E-20080 San Sebastian, Spain Moreno, AJ (reprint author), Univ Basque Country, CSIC, Ctr Fis Mat, Paseo Manuel Lardizabal 5, E-20018 San Sebastian, Spain. [email protected] Moreno, Angel/C-7313-2011; Sciortino, Francesco/B-4768-2012; CSIC-UPV/EHU, CFM/F-4867-2012 EU [FP7-PEOPLE-2007-1-1-ITN, MAT2007-63681, IT-436-07, ERC-226207-PATCHYCOLLOIDS, ITN-234810-COMPLOIDS] We thank S.-H. Chong, T. Franosch, M. Fuchs, M. Sperl, and J. Baschnagel for useful discussions. We acknowledge financial support from projects FP7-PEOPLE-2007-1-1-ITN (DYNACOP, EU), MAT2007-63681 (Spain), IT-436-07 (GV, Spain), ERC-226207-PATCHYCOLLOIDS (EU), and ITN-234810-COMPLOIDS (EU). 50 2 2 AMER INST PHYSICS MELVILLE CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA 0021-9606 J CHEM PHYS J. Chem. Phys. JAN 14 2011 134 2 024523 10.1063/1.3525147 12 Physics, Atomic, Molecular & Chemical Physics 709WK WOS:000286471900064 J Zammataro, M; Chiechio, S; Montana, MC; Traficante, A; Copani, A; Nicoletti, F; Gereau, RW Zammataro, Magda; Chiechio, Santina; Montana, Michael C.; Traficante, Anna; Copani, Agata; Nicoletti, Ferdinando; Gereau, Robert W. mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists MOLECULAR PAIN English Article NAAG PEPTIDASE INHIBITORS; MESSENGER-RNA EXPRESSION; RAT FORMALIN TEST; GROUP-II; N-ACETYLASPARTYLGLUTAMATE; SPINAL-CORD; UP-REGULATION; PERSISTENT; MODELS; PRETREATMENT Group II metabotropic glutamate receptors (mGluRs) couple to the inhibitory G-protein Gi. The group II mGluRs include two subtypes, mGlu2 and mGlu3, and their pharmacological activation produces analgesic effects in inflammatory and neuropathic pain states. However, the specific contribution of each one of the two subtypes has not been clarified due to the lack of selective orthosteric ligands that can discriminate between mGlu2 and mGlu3 subtypes. In this study we used mGlu2 or mGlu3 knock-out mice to dissect the specific role for these two receptors in the endogenous control of inflammatory pain and their specific contribution to the analgesic activity of mixed mGlu2/3 receptor agonists. Our results showed that mGlu2(-/-) mice display a significantly greater pain response compared to their wild type littermates. Interestingly the increased pain sensitivity in mGlu2(-/-) mice occurred only in the second phase of the formalin test. No differences were observed in the first phase. In contrast, mGlu3(-/-) mice did not significantly differ from their wild type littermates in either phase of the formalin test. When systemically injected, a single administration of the mGlu2/3 agonist, LY379268 (3 mg/kg, ip), showed a significant reduction of both phases in wild-type mice and in mGlu3(-/-) but not in mGlu2(-/-) mice. However tolerance to the analgesic effect of LY379268 (3 mg/kg, ip) in mGlu3(-/-) mice developed following 5 consecutive days of injection. Taken together, these results demonstrate that: (i) mGlu2 receptors play a predominant role over mGlu3 receptors in the control of inflammatory pain in mice; (ii) the analgesic activity of mixed mGlu2/3 agonists is entirely mediated by the activation of the mGlu2 subtype and (iii) the development of tolerance to the analgesic effect of mGlu2/3 agonists develops despite the lack of mGlu3 receptors. [Chiechio, Santina; Copani, Agata] Univ Catania, Dept Drug Sci, I-95124 Catania, Italy; [Zammataro, Magda] Univ Catania, Ph D Program Neuropharmacol, I-95124 Catania, Italy; [Montana, Michael C.; Gereau, Robert W.] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA; [Montana, Michael C.; Gereau, Robert W.] Washington Univ, Sch Med, Pain Ctr, St Louis, MO 63110 USA; [Traficante, Anna; Nicoletti, Ferdinando] INM Neuromed, Pozzilli, Italy; [Nicoletti, Ferdinando] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Rome, Italy Chiechio, S (reprint author), Univ Catania, Dept Drug Sci, I-95124 Catania, Italy. [email protected] National Institutes of Health [R01NS42595] We thank Professor S. Nakanishi for providing the mGlu2-/- mice. This work was supported by funds from the National Institutes of Health (R01NS42595) to RWG. 37 2 2 BIOMED CENTRAL LTD LONDON 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND 1744-8069 MOL PAIN Mol. Pain JAN 14 2011 7 6 10.1186/1744-8069-7-6 5 Neurosciences Neurosciences & Neurology 712PJ WOS:000286678400001 J Wang, K; Diskin, SJ; Zhang, HT; Attiyeh, EF; Winter, C; Hou, CP; Schnepp, RW; Diamond, M; Bosse, K; Mayes, PA; Glessner, J; Kim, C; Frackelton, E; Garris, M; Wang, Q; Glaberson, W; Chiavacci, R; Nguyen, L; Jagannathan, J; Saeki, N; Sasaki, H; Grant, SFA; Iolascon, A; Mosse, YP; Cole, KA; Li, HZ; Devoto, M; McGrady, PW; London, WB; Capasso, M; Rahman, N; Hakonarson, H; Maris, JM Wang, Kai; Diskin, Sharon J.; Zhang, Haitao; Attiyeh, Edward F.; Winter, Cynthia; Hou, Cuiping; Schnepp, Robert W.; Diamond, Maura; Bosse, Kristopher; Mayes, Patrick A.; Glessner, Joseph; Kim, Cecilia; Frackelton, Edward; Garris, Maria; Wang, Qun; Glaberson, Wendy; Chiavacci, Rosetta; Nguyen, Le; Jagannathan, Jayanti; Saeki, Norihisa; Sasaki, Hiroki; Grant, Struan F. A.; Iolascon, Achille; Mosse, Yael P.; Cole, Kristina A.; Li, Hongzhe; Devoto, Marcella; McGrady, Patrick W.; London, Wendy B.; Capasso, Mario; Rahman, Nazneen; Hakonarson, Hakon; Maris, John M. Integrative genomics identifies LMO1 as a neuroblastoma oncogene NATURE English Article COPY NUMBER; CHROMOSOMAL TRANSLOCATIONS; ACTIVATING MUTATIONS; ALK KINASE; GENE; TRANSCRIPTION; CANCER; INTERACTS; TARGET; CELLS Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for approximately 10% of all paediatric oncology deaths(1,2). To identify genetic risk factors for neuroblastoma, we performed a genome-wide association study (GWAS) on 2,251 patients and 6,097 control subjects of European ancestry from four case series. Here we report a significant association within LIM domain only 1 (LMO1) at 11p15.4 (rs110419, combined P = 5.2 x 10(-16), odds ratio of risk allele = 1.34 (95% confidence interval 1.25-1.44)). The signal was enriched in the subset of patients with the most aggressive form of the disease. LMO1 encodes a cysteine-rich transcriptional regulator, and its paralogues (LMO2, LMO3 and LMO4) have each been previously implicated in cancer. In parallel, we analysed genome-wide DNA copy number alterations in 701 primary tumours. We found that the LMO1 locus was aberrant in 12.4% through a duplication event, and that this event was associated with more advanced disease (P < 0.0001) and survival (P = 0.041). The germline single nucleotide polymorphism (SNP) risk alleles and somatic copy number gains were associated with increased LMO1 expression in neuroblastoma cell lines and primary tumours, consistent with a gain-of-function role in tumorigenesis. Short hairpin RNA (shRNA)-mediated depletion of LMO1 inhibited growth of neuroblastoma cells with high LMO1 expression, whereas forced expression of LMO1 in neuroblastoma cells with low LMO1 expression enhanced proliferation. These data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression. [Wang, Kai; Zhang, Haitao; Hou, Cuiping; Glessner, Joseph; Kim, Cecilia; Frackelton, Edward; Glaberson, Wendy; Chiavacci, Rosetta; Grant, Struan F. A.; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA; [Diskin, Sharon J.; Attiyeh, Edward F.; Winter, Cynthia; Schnepp, Robert W.; Diamond, Maura; Bosse, Kristopher; Mayes, Patrick A.; Garris, Maria; Wang, Qun; Nguyen, Le; Jagannathan, Jayanti; Mosse, Yael P.; Cole, Kristina A.; Maris, John M.] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA; [Diskin, Sharon J.; Attiyeh, Edward F.; Winter, Cynthia; Schnepp, Robert W.; Diamond, Maura; Bosse, Kristopher; Mayes, Patrick A.; Garris, Maria; Wang, Qun; Nguyen, Le; Jagannathan, Jayanti; Mosse, Yael P.; Cole, Kristina A.; Maris, John M.] Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA; [Nguyen, Le; Li, Hongzhe; Devoto, Marcella] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA; [Saeki, Norihisa; Sasaki, Hiroki] Natl Canc Ctr, Res Inst, Div Genet, Tokyo 1040045, Japan; [Nguyen, Le; Grant, Struan F. A.; Mosse, Yael P.; Cole, Kristina A.; Devoto, Marcella; Hakonarson, Hakon; Maris, John M.] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA; [Grant, Struan F. A.; Devoto, Marcella; Hakonarson, Hakon] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA; [Iolascon, Achille; Capasso, Mario] CEINGE Biotecnol Avanzate, I-80145 Naples, Italy; [Devoto, Marcella] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy; [McGrady, Patrick W.] Univ Florida, Dept Stat, Gainesville, FL 32603 USA; [McGrady, Patrick W.] Childrens Oncol Grp, Gainesville, FL 32603 USA; [London, Wendy B.] Dana Farber Childrens Hosp, Ctr Canc, Boston, MA 02115 USA; [London, Wendy B.] Childrens Oncol Grp, Boston, MA 02115 USA; [Iolascon, Achille; Capasso, Mario] Univ Naples Federico 2, Dept Biochem & Med Biotechnol, I-80131 Naples, Italy; [Rahman, Nazneen] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England Hakonarson, H (reprint author), Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA. [email protected]; [email protected] National Institutes of Health [R01-CA124709]; Giulio D'Angio Endowed Chair; Alex's Lemonade Stand Foundation; Evan Dunbar Foundation; Rally Foundation; Andrew's Army Foundation; Abramson Family Cancer Research Institute; Howard Hughes Medical Institute; Associazione Oncologia Pediatrica e Neuroblastoma; Cotswold Foundation; Children's Hospital of Philadelphia; [UL1-RR024134-03] We acknowledge the Children's Oncology Group for providing most blood and tumour specimens and clinical and outcome data (U10-CA98543 and U10-CA98413) from neuroblastoma patients. We thank G. P. Tonini for providing neuroblastoma DNA samples in the Italian replication cohort. This work was supported in part by National Institutes of Health grant R01-CA124709 (to J.M.M.), the Giulio D'Angio Endowed Chair (J.M.M.), the Alex's Lemonade Stand Foundation (J.M.M.), the Evan Dunbar Foundation (J.M.M.), the Rally Foundation (J.M.M.), Andrew's Army Foundation (J.M.M.), the Abramson Family Cancer Research Institute (J.M.M.), a Howard Hughes Medical Institute Research Training Fellowship (K. B.), a fellowship from Associazione Oncologia Pediatrica e Neuroblastoma (M. C.), a Research Development Award from the Cotswold Foundation (H. H.), UL1-RR024134-03 (H. H.) and an Institutional Development Award to the Center for Applied Genomics from the Children's Hospital of Philadelphia (H.H.). 22 30 32 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0028-0836 NATURE Nature JAN 13 2011 469 7329 216 220 10.1038/nature09609 5 Multidisciplinary Sciences Science & Technology - Other Topics 705NO WOS:000286143400039 J Nottola, SA; Cecconi, S; Bianchi, S; Motta, C; Rossi, G; Continenza, MA; Macchiarelli, G Nottola, Stefania A.; Cecconi, Sandra; Bianchi, Serena; Motta, Cecilia; Rossi, Gianna; Continenza, Maria A.; Macchiarelli, Guido Ultrastructure of isolated mouse ovarian follicles cultured in vitro REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY English Article TRANSMISSION ELECTRON-MICROSCOPY; GRANULOSA-CELL PROLIFERATION; BOVINE PREANTRAL FOLLICLES; PRE-ANTRAL FOLLICLES; LONG-TERM CULTURE; STIMULATING-HORMONE; DEVELOPMENTAL COMPETENCE; FOLLICULAR DEVELOPMENT; PRIMORDIAL FOLLICLES; LUTEINIZING-HORMONE Background: In vitro maturation of ovarian follicles, in combination with cryopreservation, might be a valuable method for preserving and/or restoring fertility in mammals with impaired reproductive function. Several culture systems capable of sustaining mammalian follicle growth in vitro have been developed and many studies exist on factors influencing the development of in vitro grown oocytes. However, a very few reports concern the ultrastructural morphology of in vitro grown follicles. Methods: The present study was designed to evaluate, by transmission and scanning electron microscopy, the ultrastructural features of isolated mouse preantral follicles cultured in vitro for 6 days in a standard medium containing fetal calf serum (FCS). The culture was supplemented or not with FSH. Results: The follicles cultured in FCS alone, without FSH supplementation (FCS follicles), did not form the antral cavity. They displayed low differentiation (juxta-nuclear aggregates of organelles in the ooplasm, a variable amount of microvilli on the oolemma, numerous granulosa cell-oolemma contacts, signs of degeneration in granulosa cell compartment). Eighty (80)% of FSH-treated follicles formed the antral cavity (FSH antral follicles). These follicles showed various ultrastructural markers of maturity (spreading of organelles in ooplasm, abundant microvilli on the oolemma, scarce granulosa cell-oolemma contacts, granulosa cell proliferation). Areas of detachment of the innermost granulosa cell layer from the oocyte were also found, along with a diffuse granulosa cell loosening compatible with the antral formation. Theca cells showed an immature morphology for the stage reached. Twenty (20)% of FSH-treated follicles did not develop the antral cavity (FSH non-antral follicles) and displayed morphological differentiation features intermediate between those shown by FCS and FSH antral follicles (spreading of organelles in the ooplasm, variable amount of microvilli, scattered granulosa cell-oolemma contacts, signs of degeneration in granulosa cell compartment). Conclusions: It is concluded that FSH supports the in vitro growth of follicles, but the presence of a diffuse structural granulosa cell-oocyte uncoupling and the absence of theca development unveil the incomplete efficiency of the system. The present study contributes to explain, from a morphological point of view, the effects of culture conditions on the development of mouse in vitro grown follicles and to highlight the necessity of maintaining efficient intercellular communications to obtain large numbers of fully-grown mature germ cells. [Cecconi, Sandra; Bianchi, Serena; Rossi, Gianna; Continenza, Maria A.; Macchiarelli, Guido] Univ Aquila, Dept Hlth Sci, I-67100 Laquila, Italy; [Nottola, Stefania A.; Motta, Cecilia] Univ Roma La Sapienza, Dept Anat Histol Forens Med & Orthopaed, Rome, Italy; [Macchiarelli, Guido] Univ Aquila, Ctr Microscopy, I-67100 Laquila, Italy Macchiarelli, G (reprint author), Univ Aquila, Dept Hlth Sci, I-67100 Laquila, Italy. [email protected] Italian Ministry of Education, University and Research, "La Sapienza" University, Rome; Italian Ministry of Education, University and Research, University of L'Aquila T
Thematic Review on Women’s Perception of Safety While Walking in Public Space: The STEP UP Project
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Thematic Review on Women’s Perception of Safety While Walking in Public Space: The STEP UP Project
by Lily Scarponi
1 [ORCID] , Lamia Abdelfattah
1, Andrea Gorrini
1 [ORCID] , Catalina Valenzuela Cortés
1, Gerardo Carpentieri
2 [ORCID] , Carmen Guida
2 [ORCID] , Floriana Zucaro
2 [ORCID] , Florencia Andreola
3, Azzurra Muzzonigro
3, Laura Da Re
3 [ORCID] , Eleonora Gargiulo
4, Carlos Cañas
4, Jim Walker
4 [ORCID] and Rawad Choubassi
1,*
1
Fondazione Transform Transport ETS, Via Lovanio 8, 20121 Milan, Italy
2
TeMA Lab, Dipartimento di Ingegneria Civile, Edile e Ambientale, Università degli Studi di Napoli Federico II, Piazzale Tecchio, 80, 80125 Naples, Italy
3
Sex and the City APS, Via della Moscova 58, 20121 Milan, Italy
4
Walk21 Foundation, 24 Moorend Road, Cheltenham, Gloucestershire GL530HD, UK
*
Author to whom correspondence should be addressed.
Sustainability 2023, 15(21), 15636; https://doi.org/10.3390/su152115636
Submission received: 13 September 2023 / Revised: 16 October 2023 / Accepted: 30 October 2023 / Published: 5 November 2023
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Abstract
The contributions of this paper are the result of a thematic review conducted on some of the most relevant scientific contributions and policy guidelines about women’s perception of safety while walking in public spaces. The first part of the review focused on 23 scientific references revolving around the keywords “gender”, “safety” and “walkability”. This led to the establishment of three main Safety Factors: (i) Spatial Features (space characteristics/morphological features); (ii) City Use (traces of behavior and presence of city users); and (iii) Hotspots (safe havens and no-go areas); further resulting in 19 sub-factors. The second part of the review covered a collection of 20 reports and 10 guidelines focused on diverse geographical scales, areas of interest and target audiences, as well as data collection methods. This involved the selection of multiple case studies, which are also presented, thus maintaining a geographically diverse sample. As part of the scientific research project “STEP UP—Walkability for Women in Milan”, the outputs of the proposed thematic review will be exploited to help identify challenging areas of Milan (Italy), as samples of analysis to develop a set of policy recommendations to enhance the level of walkability for women
La dottrina giuslavoristica italiana di fronte al mutamento delle relazioni sindacali e alla questione della rappresentatività = Italian labor law doctrine in the face of changing trade union relations and the question of representativeness. WP C.S.D.L.E. “Massimo D’Antona”.IT – 295/2016
No full textThe article offers a general overview of the Italian Labour law scholar’s opinions about the evolution of trade – union Italian legal system with respect to the change of the model of industrial relations. The essay focuses the key role played by the concept of “ trade - union representation” in basic matters like collective bargaining procedures and worker’s representation at plant level. The new set of rules arising in different way both from the legal order and from the autonomous social partners agreements shows weakness and strength. In the last part the Author discusses the different content and approach of two separate bills settled recently by two groups of Labour law scholars in order to have in the future a new Statutory Act in this matter
High-performance versatile setup for simultaneous Brillouin-Raman micro-spectroscopy
No full textThis is the author accepted manuscript. The final version is available from American Physical Society via the DOI in this record.Brillouin and Raman scattering spectroscopy are established techniques for the nondestructive contactless and label-free readout of mechanical, chemical and structural properties of condensed matter. Brillouin-Raman investigations currently require separate measurements and a site-matched approach to obtain complementary information from a sample.
Here we demonstrate a new concept of fully scanning multimodal micro-spectroscopy for simultaneous detection of Brillouin and Raman light scattering in an exceptionally wide spectral range, from fractions of GHz to hundreds of THz. It yields an unprecedented 150 dB contrast, which is especially important for the analysis of opaque or turbid media such as biomedical samples, and spatial resolution on a sub-cellular scale.
We report the first applications of this new multimodal method to a range of systems, from a single cell to the fast reaction kinetics of a curing process, and the mechano-chemical mapping of highly scattering biological samples.S. Corezzi acknowledges financial support from MIUR-PRIN (Project No. 2012J8X57P). S. Caponi acknowledges support from PAT (Provincia Autonoma di Trento) (GP/PAT/2012) “Grandi Progetti 2012” Project “MaDEleNA.” P. S., A. M., M. P. acknowledge financial support from Centro Nazionale Trapianti (Project: “Studio di cellule per uso clinico umano, con particolare riferimento a modelli cellulari (liposomi) e linee cellulari in interazione con crioconservanti e con materiali biocompatibili”). L. C. and S. Caponi acknowledge financial support from Consiglio Nazionale delle Ricerche-Istituto Officina dei Materiali. F. P. acnowledges support from the UK Engineering and Physical Sciences Research Council (Grant No. EP/M028739/1 (F. P.)). The authors acknowledge Jacopo Scarponi for valuable help in setting up the hardware and software system for simultaneous Raman and BLS measurements
A agricultura urbana e o "bem viver" nos espaços urbanos: um estudo de caso sobre as hortas comunitárias do município de Joinville/SC
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Agroecossistemas, Florianópolis, 2015.Este trabalho teve como pano de fundo apresentar uma experiência de agricultura urbana que deu certo, que tem potencial para ser um instrumento resgatador de sentimentos e valores humanos que transpõem o conceito de qualidade de vida. O objetivo desta dissertação foi examinar as contribuições da Agricultura Urbana para o bem viver no espaço das cidades, a partir da experiência de agricultoras e agricultores urbanos das hortas comunitárias do município de Joinville. As Hortas Comunitárias Girassol, dos Ipês e da Figueira são o recorte dessa pesquisa e foram articuladas e implantadas, a partir de 2008, pelo Laboratório de Educação do Campo e Estudos da Reforma Agrária (LECERA) da Universidade Federal de Santa Catarina (UFSC) com recursos do extinto Programa de Agricultura Urbana do Governo Federal. A metodologia adotada privilegiou procedimentos que permitissem uma análise qualitativa. A técnica do grupo focal foi utilizada para levantamento dos dados e a análise de conteúdo para compreender criticamente o sentido das comunicações e suas significações. Para captar e essência e as nuances das contribuições da agricultura urbana investigada optou-se por elaborar um construto sobre bem viver. No referencial teórico interdisciplinar, pautado nos contributos da filosofia grega, notadamente sobre a noção geral de felicidade, bem como nas teorias de Marx sobre o trabalho e na de Max-Neef sobre o desenvolvimento da escala humana, encontrou-se fundamentos universais úteis ao debate sobre bem viver. Efeitos benéficos no campo do econômico, social, subjetivo/simbólico e da saúde foram apontados pelos agricultores urbanos como derivados da prática da agricultura urbana, norteando a elaboração do construto. Ideias como liberdade, respeito, realização pessoal, companheirismo, solidariedade, generosidade, amizade, prazer em viver, pertencimento, soberania alimentar, trabalho libertador e um completo bem-estar físico, mental e social, extraídas da pesquisa podem ser apontadas como noções aglutinadoras para o entendimento que se elaborou sobre bem viver. A partir das análises e reflexões desta pesquisa se supõe possível existir um bem viver para aquelas pessoas, naquelas condições, no tempo e nos espaços em que vivem, o qual se chamou de bem viver contingente. Talvez, a maior contribuição da agricultura urbana para o bem viver se dê pelo seu potencial de intervenção no plano da cultura. Para além de provedora de alimentos saudáveis e frescos, constitui-se num lócus do fazer político no qual as populações, sobretudo as desassistidas, vão lentamente transformando-se de um mero número nas estatísticas, para cidadãos dotados de direitos e deveres. Supondo-a num cenário promissor com condições políticas de se materializar, a agricultura urbana poderia representar uma generosa circunstância segundo a qual as pessoas teriam a possibilidade de se aproximar, ou mesmo de se reencontrar, com a noção de bem viver.Abstract : This work had as backdrop to present an experience of urban agriculture that worked, that has the potential to be a rescuer instrument of feelings and human values that transpose the concept of quality of life. The objective of this dissertation was to examine the Urban Agriculture contributions to a good way of living in the space of the cities, from the experience of urban agriculturists of the city of Joinville's communitarian gardens The Girassol, Ipês and Figueira community gardens, are the clipping of this research and were articulated and implemented since 2008, by the Rural Education and Agrarian Reform Studies Laboratory(LECERA) at the Federal University of Santa Catarina (UFSC) with funds from the Federal Government's defunct National Urban Agriculture Program. The adopted methodology focused on procedures that allowed a qualitative analysis. The focus group technique was used to survey data and content analysis to critically understand the speeches and their meanings. To capture the essence and the nuances of the investigated urban agriculture contributions we decided to develop a construct of good living. In the interdisciplinary theoretical referential, guided by the Greek philosophy contributions, notably on the general notion of happiness, as well as on the theories of Marx about the workplace and of Max-Neef on the human scale development, it was found universal fundamentals relevant to the good living debate. Beneficial effects in the economic, social, subjective/symbolic and health field were appointed by urban agriculturists as derived from the practice of urban agriculture, guiding the elaboration of the construct. Ideas such as freedom, respect, personal achievement, Fellowship, solidarity, generosity, friendship, happy living, belonging, food sovereignty, liberating work and a complete physical, mental and social well-being, that were extracted from the survey can be identified as agglutinating notions to the understanding of what was elaborated about good living. From the analysis and reflections of this research it is beliaved to be possible the existance of a good living to those people, under those conditions, in the time and in the spaces in which they live, which is called good living contingent. Perhaps the greatest contribution of urban agriculture to good living is given by its potential for action in the field of culture. In addition to providing healthy and fresh food, it constitutes a political locus in which the population, especially the most neglected, slowly become, from a mere number in statistics, citizenswith rights and duties. Assuming a promising scenario with political conditions to materialize, urban agriculture could represent a generous condition whereby people would have the possibility to approach, or even to be reunited, with the notion of good living
Correction to: Screening of postpartum diabetes in women with gestational diabetes: high‐risk subgroups and areas for improvements—the STRONG observational study (Acta Diabetologica, (2021), 58, 9, (1187-1197), 10.1007/s00592-021-01707-9)
No full textAuthors would like to correct the error in their publication. Figure 3 contains a part in Italian language which is now removed. The collaborator author names were tagged only in the author group but missed to process in Acknowledgements section. The collaborator author names now updated as Study group in the Acknowledgements section. The original article has been corrected
