1,721,140 research outputs found
Carcinoma mammario e sopravvivenza: un end point reale.
No full textGli studi clinici ed i trattamenti del carcinoma mammario vengono discussi
Multiscale approaches for the simulation of InGaN/GaN LEDs
No full textIn this work we review basic aspects of multi-
scale approaches for combining atomistic with continuous
media descriptions and quantum mechanical with semiclassi-
cal driftdiffusion transport models for LED simulations. We
show how hybrid coupling of the Green's function formalism
with driftdiffusion simulations can give additional insight
into device behaviour without compromising too much com-
putational efficiency, and that the inclusion of atomistic tight-
binding calculations in a multiscale framework can help in
understanding specific features related to alloy fluctuations
Primary Systemic Therapy in operable breast cancer: clinical data and biological fall-out
No full textAbstract
Primary systemic chemotherapy (PST) was first used in early 1970s for the treatment of locally advanced breast cancer; in this setting primary chemotherapy was administered to allow for radical surgery and the objective response rates were high with a substantial proportion of patients amenable to surgery. On the basis of this activity, PST was subsequently used to treat operable locally advanced or large primary tumors to increase the rate of conservative surgery. First generation clinical trials demonstrated that breast conservation rates were improved, that a proportion of patients experienced a complete pathologic response and that response to PST was a good predictor of long term outcome. Second generation of clinical trials were designed to compare PST to postoperative adjuvant chemotherapy: here again the rate of conservative surgery was significantly improved and the pathologic response rate demonstrated its prognostic value, however no progression free or survival improvement was obtained in comparison with postoperative treatments. Another interesting observation from these trials was that some tumor parameters (histology, grade, hormone receptor status) can predict the likelihood of achieving a pathologic complete response. On the basis of these data, PST can now be considered the standard of care for locally advanced disease, an reasonable option in case of large primary breast tumors not eligible for conservative surgery and an acceptable alternative for all the patients who are candidate to adjuvant treatment. It however clear that PST represents an excellent in vivo model to test new regimens, to evaluate biomarkers with predictive value and to evaluate the treatment induced modifications in tumor biology. Availability of new technologies able to measure the expression of thousands of genes and of new molecularly directed drugs will increase further the interest in this treatment strategy
A Suitable Approach to Assess Thermal Properties of GaN Power Bars
No full textThis paper describes the activities carried out to assess the thermal behavior of a Gallium Nitride (GaN) power bar grown on Silicon Carbide (SiC) substrate. The aim is to set up a reliable approach to extract an accurate value of the device thermal resistance (R th ), under different base-plate temperatures and dissipated power values. To this purpose, both Raman spectroscopy (RS) and photo-current (PC) techniques were experimentally applied to verify the results obtained from simulations based on finite element analysis. Such activity was carried out in the framework of a project aiming to develop a Solid State Power Amplifier (SSPA) for space applications, where thermal management is of primary importance. Even if with some differences, the comparisons between measured and simulated values have confirmed that both RS and PC techniques can be applied to experimentally verify the simulation's assumptions
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Optical resolution of light engine based on InGaN/GaN nanoLED arrays: Toward a superresolved light source
Full text linkVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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