5,191 research outputs found
Il Rimbaud di Mario Matucci
No full textRiprendo volutamente il titolo del bel saggio di Ivos Margoni apparso nel volume degli Studi in onore di Mario Matucci per rileggere, con il favore di un maggiore recul nel tempo, secondo il prezioso consiglio di Lukács, il contributo di Mario Matucci agli studi su Rimbaud, in occasione della ristampa di due importanti tappe della lettura rimbaldiana e cioè la «versione con testo a fronte, introduzione e note» di Illuminations e di Une Saison en Enfer. La scelta di partire da Margoni ha anche..
Mario Matucci, Les deux visages de Rimbaud, 1986
No full textFongaro Antoine. Mario Matucci, Les deux visages de Rimbaud, 1986. In: Littératures 17, automne 1987. pp. 205-208
Sentiment et sensibilité dans l'œuvre romanesque de Marivaux
No full textMatucci Mario. Sentiment et sensibilité dans l'œuvre romanesque de Marivaux. In: Cahiers de l'Association internationale des études francaises, 1973, n°25. pp. 127-139
De Baudelaire à Rimbaud : le chemin de la voyance
No full textMatucci Mario. De Baudelaire à Rimbaud : le chemin de la voyance. In: Cahiers de l'Association internationale des études francaises, 1984, n°36. pp. 239-251
Alan Freer : Ricerche sull' «Encyclopédie ». Éd. Goliardica, 1972.(Coll. «Studi e Testi », 40.)
No full textMatucci Mario. Alan Freer : Ricerche sull' «Encyclopédie ». Éd. Goliardica, 1972.(Coll. «Studi e Testi », 40.). In: Dix-huitième Siècle, n°7, 1975. p. 418
Contro la funzionalizzazione della contrattazione collettiva. Riflessioni sul pensiero di Mario Rusciano
No full textL'autore riflette sul pensiero di Mario Rusciano in punto di funzionalizzazione della contrattazione collettiva.The author reflects on the thought of Mario Rusciano in relation to the subject of the functionalisation of collective bargaining
Gli «Idéologues » e la Rivoluzione. Actes du Colloque international de Grosseto (sept. 1989). Éd. par Mario Matucci, 1991
No full textDesné Roland. Gli «Idéologues » e la Rivoluzione. Actes du Colloque international de Grosseto (sept. 1989). Éd. par Mario Matucci, 1991. In: Dix-huitième Siècle, n°24, 1992. Le matérialisme des Lumières. pp. 565-566
Lumières et Illuminisme. Actes du colloque Cortona (3-6 octobre 1983). Textes réunis par Mario Matucci, (Coll. «Critica e storia letteraria », 9) 1985
No full textGoggi Gianluigi. Lumières et Illuminisme. Actes du colloque Cortona (3-6 octobre 1983). Textes réunis par Mario Matucci, (Coll. «Critica e storia letteraria », 9) 1985. In: Dix-huitième Siècle, n°18, 1986. Littératures françaises. p. 449
Potent muscarinic antagonists bearing 1,4-dioxane scaffold
No full textMuscarinic receptor antagonists are used in the treatment of airway, bladder, and gastrointestinal smooth muscle disorders. In the treatment of overactive bladder (OAB) and OAB symptoms they are often associated with detrusor overactivity (DO) and exert their effects by inhibiting the binding of acetylcholine at muscarinic receptors M2 and M3 on detrusor smooth muscle cells and other structures within the bladder wall.1
(1,3-dioxolan-4-yl)-N,N,N-trimethylmethanaminium iodide nucleus has been used for many years as a scaffold for its ability to give potent muscarinic agonists or antagonists, depending on the size of the substituent in position 2 (methyl or bulkier group, respectively).2 The enlargement of the 1,3-dioxolane nucleus of 1 by inserting a methylene group between the 1-oxygen atom and the 2-carbon atom afforded the potent muscarinic agonist 2, which preferentially activated M2 and M3 subtypes.3 Therefore, to obtain a potent antagonist useful in the treatment of OAB, in the present study two phenyl rings have been inserted in position 6 of the 1,4-dioxane scaffold (compound 3). Moreover, since it is well known that muscarinic receptors display stereoselective requirements and the biological activity of muscarinic ligands is closely related to their stereochemistry,4 the racemate 3 has also been resolved into its two enantiomers via an oxazolidinone auxiliary mediated resolution. The absolute configuration of the two enantiomers has been determined through X-ray diffraction analysis of the dextrorotatory form.
The pharmacological profile of racemate 3 and its two enantiomers was evaluated by receptor binding assays on Chinese hamster ovary (CHO) cells, expressing the five human muscarinic subtypes (hm1-hm5). From preliminary results compound 3 showed nM affinity values significantly similar to those of N-methylscopolamine at all muscarinic subtypes. The eutomer was the levorotatory form (S)-(−)-3 at all muscarinic M1-M5 subtypes, with eudismic ratios of 32, 12, 42, 102 and 63, respectively.
References
1) Abrams, P.; Andersson, K.-E. BJU Int. 2007,100, 987-1006
2) a) Angeli, P. Farmaco 1995, 50, 565-77. b) Angeli, P. Farmaco 1998, 53, 1-21.
3) Piergentili, A.; Quaglia, W.; Giannella, M.; Del Bello, F.; Buccioni, M.; Nesi, M.; Matucci, R. Bioorg. Med. Chem. Lett. 2008, 18, 614-618.
4) Scapecchi, S.; Matucci, R.; Bellucci, C.; Buccioni, M.; Dei, S.; Guandalini, L.; Martelli, C.; Manetti, D.; Martini, E.; Marucci, G.; Nesi, M.; Romanelli, M. N.; Teodori, E.; Gualtieri, F. J. Med. Chem. 2006, 49, 1925-1931
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