1,721,063 research outputs found
The Discovery, Use and Impact of Platinum Salts as Chemotherapy Agents for Cancer
No full textAnnotated and edited transcript of a Witness Seminar held on 4 April 2006. Introduction by Professor Matti Aapro, Grenolier, Switzerland.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2007.©The Trustee of the Wellcome Trust, London, 2007. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 4 April 2006. Introduction by Professor Matti Aapro, Grenolier, Switzerland.Annotated and edited transcript of a Witness Seminar held on 4 April 2006. Introduction by Professor Matti Aapro, Grenolier, Switzerland.Annotated and edited transcript of a Witness Seminar held on 4 April 2006. Introduction by Professor Matti Aapro, Grenolier, Switzerland.Annotated and edited transcript of a Witness Seminar held on 4 April 2006. Introduction by Professor Matti Aapro, Grenolier, Switzerland.Annotated and edited transcript of a Witness Seminar held on 4 April 2006. Introduction by Professor Matti Aapro, Grenolier, Switzerland.Proposed by Dr Mark Walport (Wellcome Trust) this Seminar examined the discovery, use and impact of platinum salts as chemotherapy agents for cancer. Organized with the assistance of Professor Paul Andrews (St George's Hospital Medical School) and Dr Tony Woods (Wellcome Trust) and chaired by Professor Sir Kenneth Calman (Durham) the Seminar discussed the serendipitous emergence of platinum salts as widely used anticancer agents from a chance observation in a microbiology laboratory; through their use especially for the treatment of previously untreatable solid tumours such as those of the testes and ovary; and their significance in the development of antiemetic agents for chemotherapy patients. Participants included chemists, oncologists, and academic and industrial pharmacologists who devised, in particular, the 5HT3 receptor antagonists. Participants included: Professor Kenneth Bagshawe, Dr Penelope Brock, Professor Hilary Calvert, Professor David Grahame-Smith, Professor Richard Gralla, Professor Kenneth Harrap, Dr James Hoeschele, Professor Ian Judson, Mr Wesley Miner, Professor Robert Naylor, Mrs Brenda Reynolds, Dr John Rudd, Dr Gareth Sanger, Dr David Tattersall, Professor Andrew Thomson, Professor Robert Williams and Dr Eve Wiltshaw. Christie D A, Tansey E M. (eds) (2007) The discovery, use and impact of platinum salts as chemotherapy agents for cancer, Wellcome Witnesses to Twentieth Century Medicine, vol. 30. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Toma de decisiones terapéuticas:¿cuáles son los factores que realmente importan después del TNM?
No full textSIOG (International Society of Geriatric Oncology) recommendations for anthracycline use in the elderly
No full textA taskforce of the International Society of Geriatric Oncology (SIOG) has recently submitted recommendations on the use of anthracyclines in elderly patients. Despite the aging of the population and the high proportion of elderly individuals in the population of patients with non-Hodgkin’s lymphoma, the development of specialist expertise in the treatment of elderly patients with cancer is relatively recent. Treatment of the elderly is complex because they are a highly heterogeneous population, with large variations in health status, comorbidities and life expectancy. In addition, these patients are generally more susceptible than young patients to the cardiotoxic effects of anthracyclines. Strategies for assessing elderly patients with cancer, reducing the risk of congestive heart failure, and assessing the cardiotoxic effects of treatments are discussed. In addition, a summary of the SIOG recommendations is presented
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