1,350 research outputs found
Neutropenia Associated with Quetiapine, Olanzapine, and Aripiprazole
No full textMatthew Lander and Tarun Bastiampilla
Soccer Marks Pirate Athletics\u27 Return To Action After Matthew With 4-0 PBC Win At Lander
No full textSoccer Marks Pirate Athletics\u27 Return To Action After Matthew With 4-0 PBC Win At Lander. The Armstrong State University women\u27s soccer team returned to action, after a lengthy layoff following Hurricane Matthew\u27s trip up the southeastern coast, by picking up a 4-0 Peach Belt Conference victory at Lander University on Wednesday evening in Greenwood, S.C
The inside-out view on neutron-star magnetospheres
No full textWe construct hydromagnetic neutron star equilibria which allow for a non-zero electric current distribution in the exterior. The novelty of our models is that the neutron star's interior field is in equilibrium with its magnetosphere, thus bridging the gap between previous work in this area, which either solves for the interior assuming a vacuum exterior or solves for the magnetosphere without modelling the star itself. We consider only non-rotating stars in this work, so our solutions are most immediately applicable to slowly rotating systems such as magnetars. Nonetheless, we demonstrate that magnetospheres qualitatively resembling those expected for both magnetars and pulsars are possible within our framework. The ‘inside-out’ approach taken in this paper should be more generally applicable to rotating neutron stars, where the interior and exterior regions are again not independent but evolve together
Location and Setting of the InSight Lander, Instruments and Landing Site
No full textThis file describes data related to Golombek et al. 2020 submission "Location and Setting of the InSight Lander, Instruments and Landing Site" to the journal of Earth and Space Science. This work was performed at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). Questions regarding these data or the paper should be directed to [email protected] or [email protected].
This .zip archive contains data used in the analyses contained within the paper and its figures. Unless specified otherwise, all coordinates are reported in an equirectangular projection with a planetary radius 3396190 m corresponding to the IAU/IAG Mars 2000 positive east planetocentric coordinate system, and all measurements are reported in meters. If desired, to convert coordinates (reported as meters easting and northing) to degrees, multiply by [360/(2*pi*Radius)].Related Publication:
Location and Setting of the InSight Lander, Instruments and Landing Site
Matthew Golombek, Caltech JPL
Earth and Space Science
2020
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Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
No full text2011 February 1Soft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per year in the United States1, show remarkable histologic diversity, with more than 50 recognized subtypes2. However, knowledge of their genomic alterations is limited. We describe an integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes. Frequently mutated genes included TP53 (17% of pleomorphic liposarcomas), NF1 (10.5% of myxofibrosarcomas and 8% of pleomorphic liposarcomas) and PIK3CA (18% of myxoid/round-cell liposarcomas, or MRCs). PIK3CA mutations in MRCs were associated with Akt activation and poor clinical outcomes. In myxofibrosarcomas and pleomorphic liposarcomas, we found both point mutations and genomic deletions affecting the tumor suppressor NF1. Finally, we found that short hairpin RNA (shRNA)-based knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4, decreased cell proliferation. Our study yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.Memorial Sloan-Kettering Cancer Center (Soft Tissue Sarcoma Program Project P01 CA047179
Thermal Considerations for Designing the Next Lunar Lander
No full textThe Vision for Space Exploration calls for NASA to develop a lunar lander that is capable of delivering humans anywhere on the moon's surface at any time. This presents a significant challenge for thermal engineers, as the lander must be able to survive both the freezing 14-day long lunar night as well as the harsh lunar noon. These problems and potential solutions are presented for each stage of the proposed mission that will return American astronauts to the moon
Linear Covariance Analysis for a Lunar Lander
No full textA next-generation lunar lander Guidance, Navigation, and Control (GNC) system, which includes a state-of-the-art optical sensor suite, is proposed in a concept design cycle. The design goal is to allow the lander to softly land within the prescribed landing precision. The achievement of this precision landing requirement depends on proper selection of the sensor suite. In this paper, a robust sensor selection procedure is demonstrated using a Linear Covariance (LinCov) analysis tool developed by Draper
Sampling tool concepts for Enceladus lander in-situ analysis
No full textA potential future in-situ lander mission to the surface of Enceladus could be the lowest cost mission to determine if life exists beyond Earth since material from the subsurface ocean, where the presence of hydrothermal activity has been strongly suggested by the Cassini mission, is available on its surface after being ejected by plumes and then settling on the surface. In addition, the low radiation environment of Enceladus would not significantly alter the chemical makeup of samples recently deposited on the surface. A study was conducted to explore various sampling devices that could be used by an in-situ lander mission to provide 1cc to 5cc volume samples to instruments. In addition to temperature and vacuum environmental conditions, the low surface gravity of Enceladus (1% of Earth gravity) represents a new challenge for surface sampling that is not met by sampling systems developed for microgravity (e.g., comets and asteroids) or higher gravity (e.g., Europa 13%g, Moon 16%g, or Mars 38%g) environments. It is desired to acquire surface plume material that has accumulated in the top 1cm to ensure acquisition of the least processed material. Several sampling devices were developed or adapted and then tested in simulated conditions that resemble the Enceladus surface properties. These devices and test results are presented in this paper
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Tests of an experimental unbaited video lander as a marine fish survey tool for high-relief deepwater rocky reefs
No full textWe describe the development and practical field testing of a rugged, unbaited video lander as a visual survey tool for fishes inhabiting structurally complex, high-relief, deepwater rocky reefs. Our autonomous, high-resolution, low-light, color video lander system utilized a smooth frame design that incorporated a series of breakaway attachments and inexpensive sacrificial steel bases to maximize the potential for camera system recovery from complex rocky habitats. Initial field tests at five reef complexes off Oregon (n = 421) and a larger study evaluating the western boundary of Oregon's Yelloweye Rockfish Conservation Area (YRCA, n = 527) showed that the video lander could be deployed and reliably retrieved from high-relief rocky habitat without damage to the camera system and with minimal losses of sacrificial bases. Acceptable visibility for counting fish from the lander video was common at offshore reefs like Stonewall Bank, but less so at nearshore reef complexes. The video lander system was effective for discriminating differences in fish species assemblages at the various reefs surveyed (one-way ANOSIM, P < 0.001) and for identifying seafloor habitat types and species-habitat associations for yelloweye rockfish (Sebastes ruberrimus) at Stonewall Bank (P < 0.05). The video lander data showed that the area outside and to the west of the YRCA enclosed similar quantities of yelloweye rockfish and their preferred habitats in comparison with the area inside the YRCA (0.179 yelloweye rockfish/station outside, versus 0.144 yelloweye rockfish/station inside, Wilcoxon test, P = 0.417). Our visual survey data also showed that the current western YRCA boundary is not optimal for protecting yelloweye rockfish at Stonewall Bank from fishery harvest. â[superscript°] An unbaited video lander was tested as a survey tool for deepwater rocky reefs. â[superscript°] The design used breakaway components to aid the retrieval of undamaged equipment. â[superscript°] Field tests showed high retrievability. â[superscript°] Differences in species assemblages, abundance and habitat associations were shown.Keywords: Temperate reefs, Sampling methods, Marine protected areas, Untrawlable habitat, Yelloweye rockfish, Underwater visual censu
Europa Lander Landing System: Study on Deployment, Landing and Preliminary Design
No full textThe Europa Lander is a mission by NASA to land scientific instruments on the Jovian Moon by 2030. The current design of the landing system envisions fixed landing legs with the lander being lowered down at very low velocities (≈ 0.1 m/s) by use of a Skycrane. This latter system not only adds mass, but also requires complicated moving parts and a high reliance on control systems to work properly. This thesis wants to propose an alternative design to the Europa Lander Landing System that uses sturdier legs that can withstand landing at higher velocities than originally envisioned. This eliminates the need to use a Skycrane system. In order to pack them in a more efficient way while coasting, the landing legs are of the deployable type.In order to track the deployment dynamics of the landing system a 2-dimensional Matlab deployment model based on double pendulum motion with damping is created. Furthermore, in order to prove the landability with a prescribed landing case, a landing model is created using FEA software Abaqus. The landing model is used to make sure that stresses, strains and G forces applied to the rest of the lander don’t exceed prescribed values as dictated by requirements. The implementation of both models is verified by comparing models found in literature with the ones made for the purpose of this thesis. Good correlation is shown with less than 10% of difference between literature results and results for this thesis.The result through the modelling found a specific geometry with parameters that include, but are not limited to: length of leg elements, joint damping and maximum deployment angles. The 2-dimensional geometry features output by the Matlab deployment model are fed into the Abaqus landing model in order to assess the landing performance with a single leg landing. The landing case has been chosen as a worst case scenario. 2 landing leg designs, with the same geometry, but one made of metallic parts and the other made of composite materials are compared in the landing model. In this model it was found that both designs pass the stress (or strain for the composite leg design) and G forcesrequirements when a shock absorber is attached to the leg and when they land on deformable Lunar like soil. On the other hand, the landing legs don’t pass G forces requirements when landing on stiff soil.Through the modelling, it was also possible to give preliminary design guidelines over the subsystems making the landing system. Therefore, system engineering practices have been used in order to initiate the design of some of the subsystems such as the landing damping, the leg joints and the locking mechanism to lock the legs at the desired angle and make sure they don’t retract. Simplifications have been made in order to model some of the landing and deployment aspects of the system for this thesis. Matters related to the adaptability and the detailed design of each of the subsystems have been left as future work.In the end, a comparison between the design developed in this thesis and the current Europa Lander Landing System design is made difficult by the lack of technical data on the latter related to mass. Nevertheless, a design that uses the decelerations of the engine module before touchdown is developed and the suggested material for the leg elements is CFRP. The design, though, didn’t pass mass fraction requirements when computing the mass of the extra subsystems. Even so, locations where potential gains through mass optimization can be performed for future studies have been pointed out.Aerospace Engineerin
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