220 research outputs found
Risk of incident atrial fibrillation after COVID-19 infection: A systematic review and meta-analysis
No full textBackground: Data regarding the risk of atrial fibrillation (AF) during the post-acute phase of COVID-19 are lacking. Objective: We assessed the risk of incident AF in COVID-19 recovered patients by performing a systematic review and meta-analysis of the available data. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched Medline and Scopus to locate all articles published up to December 1, 2023, reporting the risk of AF in patients recovered from COVID-19 infection compared with noninfected patients in whom the arrhythmia developed during the same follow-up period. AF risk was evaluated by the Mantel-Haenszel random effects model with hazard ratio as the effect measure with 95% confidence interval (CI); heterogeneity was assessed by Higgins I2 statistic. Results: Overall, 19,478,173 patients (mean age, 56.5 years; 63.0% male) enrolled in 5 observational studies were included in the analysis. Of these, 5,692,510 recovered from severe acute respiratory syndrome coronavirus 2 infection. During a mean follow-up of 14.5 ± 3.2 months, a random effects model revealed a pooled incidence of new-onset AF in 2.6% of cases (95% CI, 1.8%–6.18%). Recovered COVID-19 patients presented with a higher risk of incident AF (hazard ratio, 1.57; 95% CI, 1.24–1.99; P < .0001; I2 = 77.9%) compared with noninfected patients during the same follow-up period. Sensitivity analyses confirmed the yielded results. A multivariable metaregression including age, male sex, history of hypertension, coronary artery disease, and length of follow-up was able to explain a significant part of the heterogeneity (R2 = 54.3%; P = .01). Conclusion: Recovered COVID-19 patients have a higher risk of AF events compared with individuals from the general population
A linguagem política na era digital: O populismo de Matteo Salvini na Itália
No full textIn this article, we provide an interpretation of Matteo Salvivi\u27s populist political language in Italy. Analyzing the form and content of the aesthetic and political manifestations posted on the digital media, we seek to demonstrate the strength of the emotional words and images in the construction of a new subjectivity and political audience, which enabled the success of the Lega party at Italian election of March 2018.En este artículo, ofrecemos una interpretación del lenguaje político populista de Matteo Salvini en Italia. Analizando la forma y contenido de las manifestaciones estéticas y políticas publicadas en los medios digitales, buscamos demostrar la fuerza de las palabras e imágenes emocionales en la construcción de una nueva subjetividad y audiencia política, que hizo que el partido Lega triunfara en las elecciones italianas. de marzo de 2018.Neste artigo, fornecemos uma interpretação da linguagem política populista de Matteo Salvini na Itália. Analisando a forma e o conteúdo das manifestações estéticas e políticas postadas na mídia digital, buscamos demonstrar a força das palavras e imagens emotivas na construção de uma nova subjetividade e audiência política, que possibilitou o sucesso do partido Lega na eleição italiana de março de 2018
The Role of Surgery in Pleural Mesothelioma: A Journey through the Evidence, MARS 2 and Beyond
No full textPleural mesothelioma (PM) is a rare incurable disease, predominantly linked to asbestos exposure. Not only is diagnosis difficult, but treatment choices are often limited to systemic anti-cancer treatment with chemotherapy or immunotherapy. Surgery has been employed for decades, but its application has been fiercely debated despite some randomized controlled trials such as the recent Mesothelioma and Radical Surgery 2 (MARS 2) study. We provide a commentary on this controversial topic. © The Author(s) 2025
Heart Failure-Related Death in Subjects With Atrial Fibrillation in the United States, 1999 to 2020
No full textBackground: Population-based data on heart failure (HF)-related death in patients with atrial fibrillation (AF) are lacking. We assessed HF-related death in people with AF in the United States over the past 21 years and examined differences by age, sex, race, ethnicity, urbanization, and census region. Methods and results: Data were extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research to determine trends in age-adjusted mortality rates per 100 000 people, due to HF-related death among subjects with AF aged ≥15 years. To calculate nationwide annual trends, we assessed the average annual percent change (AAPC) and annual percent change with relative 95% CIs using joinpoint regression. Between 1999 and 2020, 916 685 HF-related deaths (396 205 men and 520 480 women) occurred among US adults having a concomitant AF. The overall age-adjusted mortality rates increased (AAPC: +4.1% [95% CI, 3.8-4.4]; P<0.001), especially after 2011 (annual percent change, +6.8% [95% CI, 6.2-7.4]; P<0.001) in men (AAPC, +4.8% [95% CI, 4.4-5.1]; P<0.001), in White subjects (AAPC: +4.2% [95% CI, 3.9 to 4.6]; P<0.001) and in subjects aged <65 years (AAPC: +7.5% [95% CI, 6.7-8.4]; P<0.001). The higher percentage of deaths were registered in the South (32.8%). During the first year of the COVID-19 pandemic, a significant excess in HF-related deaths among patients with AF aged >65 years was observed. Conclusions: A worrying increase in the HF-related mortality rate among patients with AF has been observed in the United States over the past 2 decades
Political Language in the Digital Age: Matteo Salvini's Populism in Italy
No full textIn this article, we provide an interpretation of Matteo Salvivi's populist political language in Italy. Analyzing the form and content of the aesthetic and political manifestations posted on the digital media, we seek to demonstrate the strength of the emotional words and images in the construction of a new subjectivity and political audience, which enabled the success of the Lega party at Italian election of March 2018.Neste artigo, fornecemos uma interpretação da linguagem política populista de Matteo Salvini na Itália. Analisando a forma e o conteúdo das manifestações estéticas e políticas postadas na mídia digital, buscamos demonstrar a força das palavras e imagens emotivas na construção de uma nova subjetividade e audiência política, que possibilitou o sucesso do partido Lega na eleição italiana de março de 2018.Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências e LetrasUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências e Letra
Weak Chaos in the Plasma of a Fusion Device
No full textIt is known that the magnetic field which is used to confine hot plasmas in nuclear fusion devices can be described in Hamiltonian form. The time variable which appears in Hamilton equations is replaced by an angular variable around the torus. Small field errors applied on purpose, or naturally occurring instabilities of the plasma, often break good KAM surfaces and determine the presence of stochastic motion of magnetic field lines. This topic has practical implications, since particles follow magnetic field lines, and, if the former are chaotic, particles are rapidly lost towards the vacuum vessel of the device, and can damage the plasma facing components. From a theory point of view, various models have been applied to describe this experimental situation: the most common one is the analysis of the connection length Lc,w of field lines to the wall, which can be directly compared to camera images of the damage caused by energetic particles hitting the wall of the device. More sophisticated tools have been applied recently, including the Lagrangian Coherent Structures (LCS) and the Poincaré Recurrence Time, which map the presence of more or less chaotic regions inside the plasma
Prognostic significance of pathological sub-classification of pT3 rectal cancer
No full textPurpose: Patients with pT3 rectal cancer represent a heterogeneous prognostic group. A more accurate histological sub-classification of pT status has been suggested as an improvement of the TNM staging system. The aim of the study was to evaluate the prognostic implication of a histopathologic sub-classification of pT3 rectal cancer. Methods: In this retrospective single-center study, pT3 rectal cancer patients who underwent surgery from January 2000 to December 2018 were evaluated. The maximum depth of tumor invasion beyond the muscularis propria was recorded. A ROC curve identified the best prognostic cutoff value to classify patients in two prognostic groups. Survival curves were estimated by the Kaplan-Meier method, and univariate and multivariate analyses with the Cox regression model were used to find independent factors influencing survival. Results: Overall, 203 patients were included. Four millimeters was identified as the best cutoff value: 82 patients showed a depth of invasion < 4 mm (group A) and 121 ≥ 4 mm (group B). Both the estimated 5-year OS and DFS were statistically better in group A than in group B (OS: 83.9% vs 62.2%, p < 0.01; DFS: 78.3% vs 40.6%, p < 0.01). The depth of tumor invasion was an independent risk factor for OS (HR 2.25, 95% CI 1.26-3.99, p = 0.006) and DFS (HR 2.30, 95% CI 1.40-3.78, p = 0.001). Conclusion: Our findings suggest that a sub-classification of pT3 rectal cancer, based on the depth of tumor invasion, should be considered to be introduced in the TNM staging system
Misura di flussi gamma e neutronici in plasma di deuterio
No full textLa misura dei flussi di raggi gamma e neutroni emessi dai plasmi possono fornire interessanti informazioni sulle condizioni di confinamento degli ioni all'interno del plasma. Nel presente lavoro di tesi verrà prima di tutto fatta una presentazione delle tecniche sperimentali di misura della radiazione gamma e neutronica con moderni sistemi a rivelatori liquidi a scintillazione, che utilizzano la discriminazione di forma di impulso per separare i due tipi di radiazione. Successivamente verranno analizzati i primi set di dati presi in un esperimento in corso all'Università del Wisconsin-Madison ed estratti i primi segnali di flussi di neutroni e gamma in funzione del tempo, in configurazione Reversed-Field-Pinch (RFP) per il confinamento magnetico di plasmi in deuterio.ope
Trends in age- and sex-specific atrial fibrillation/flutter mortality in Italy between 2003 and 2017
No full textAimsWe sought to assess the atrial fibrillation/flutter (AF/AFL) mortality rates and relative trends among the Italian population between 2003 and 2017.MethodsData regarding the cause-specific mortality and population size by sex in 5-year age groups were extracted from the World Health Organization (WHO) global mortality database. Decedents reporting the codes I48 were extracted accordingly to the International Classification of Disease-10 (ICD-10) coding system. The age-adjusted mortality rates (AAMRs), with relative 95% confidence intervals (CIs), also stratified by sex, were determined using the direct method. Joinpoint regression analyses were used to identify periods with statistically distinct log linear trends in AF/AFL-related death rates. To calculate nationwide annual trends in AF/AFL-related mortality, we assessed the average annual percentage change (AAPC) and relative 95% CIs.ResultsOver the study period, 90 623 (57 109 females) AF-related deaths were recorded. The AF/AFL AAMR increased from 8.1 (95% CI: 7.8-8.2) deaths per 100 000 to 18.7 (16.9-20.0) deaths per 100 000 population. Joinpoint regression analysis revealed a linear increase in age-standardized AF/AFL-related mortality [AAPC: +3.6 (95% CI: 3.0-4.3, P < 0.0001)] in the entire Italian population. Moreover, the mortality rate increased with age, showing a seemingly exponential distribution with a similar trend between males and females. Although the increase was more pronounced among women [AAPC: +3.7 (95% CI: 3.1-4.3, P < 0.0001)] compared with men [AAPC: +3.4 (95% CI: 2.8-4.0, P < 0.0001)], the difference did not reach statistical significance (P = 0.16).ConclusionsIn Italy, the AF/AFL-related mortality rates linearly increased from 2003 to 2017
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