55 research outputs found
Chapter Lodovico Nocentini: A Rereader of Modern Italian Travellers to China
No full textIn 1882, Nocentini published Il primo sinologo: P. Matteo Ricci. The first secular biography of the famous Italian Jesuit to China, it posed important questions about the origins of sinology and the role of Matteo Ricci as an early modern Italian traveller in Sino-western relations. Nocentini’s rereading of Matteo Ricci and travel literature in Italy in the late nineteenth century is examined through theories proposed by Derrida, Barthes and Nabokov. These theories provide an interpretative approach to understand the rereading carried out in Nocentini’s work, as they are intended as a process of interpretation and reinterpretation, as well as appropriation of the original meaning
C.A.L.M.A. Compendium Auctorum Latinorum Medii Aevi : 7.3 (2022), Ida de Montibus comitissa - Iodocus Gaverius
No full textL’opera è un repertorio riguardante gli autori medievali le cui opere sono databili entro un arco cronologico compreso tra il VI secolo e la prima metà del XVI. Per ciascun autore, il Compendium fornisce: 1 - una scheda contenente la bibliografia generale sull’autore e che comprende: i repertori specializzati, i lessici di riferimento nazionali e internazionali, i dizionari enciclopedici, i manuali generali e alcuni studi sul singolo autore; 2 - l’elenco delle opere attribuite all’autore, incluse quelle di dubbia autenticità, e per ciascuna delle quali si segnala: il repertorio o i repertori di riferimento, l’edizione o le edizioni, i manoscritti relatori, gli studi specifici.
La pubblicazione è in fascicoli semestrali, ordinati per serie alfabetica degli autori.Founded by Michael Lapidge and the late Claudio Leonardi, and now edited by Michael Lapidge, Silvia Nocentini, and Francesco Santi, C.A.L.M.A. is designed to serve as a complete bibliography of medieval and humanist authors. Although various bibliographical reference-works exist for specialized disciplines (e.g. medicine) or for various religious orders (e.g. Franciscans), C.A.L.M.A. is the only reference-work which attempts coverage of all Latin authors in all disciplines and all religious orders.
For each author C.A.L.M.A. provides the following information:
First, a general bibliography (BIBL.GEN.) listing biographical and cultural studies on the author and his/her milieu, in the order of their date of publication. Under this heading are included references to entries in the relevant medieval encyclopedias (e.g. Lexikon des Mittelalters) and literary histories (e.g. Manitius), plus all relevant articles and monographs on the author;
Then follows a list of the author’s individual works (including works of doubtful authenticity), in alphabetical order. Published scholarship pertaining to each work is listed under the following headings:
REF: references to the work in alpha-numerical repertories (e.g. Bibliotheca Hagiographica Latina);
MSS: a list of the principal manuscripts which transmit the work—but these are listed only in cases where the work is unpublished, or in cases where a work is transmitted in an autograph manuscript;
ED: a list of published editions of the work (frequently including incunables);
STU: a list of the published studies—philological, historical, etc.—on the individual work.
C.A.L.M.A. is the result of cooperation between a number of European and North American scholars based in various universities: Barcelona, Cambridge, Cassino, Columbus (OH), Florence, Freiburg i.Br., Genoa, Geneva, Milan, Paris, Perugia, Pisa, Rome, Sassari, and Valladolid. Entries compiled by these various scholars are overseen and edited to a standard format by editors in the two principal centres of redaction, Cambridge and Florence. Each volume of C.A.L.M.A. consists of six fascicules; fascicules are issued at regular six-monthly intervals
Determination of intracellular protein-ligand binding affinity by competition binding in-cell NMR
No full textStructure-based drug development suffers from high attrition rates due to the poor activity of lead compounds in cellular and animal models caused by low cell penetrance, off-target binding or changes in the conformation of the target protein in the cellular environment. The latter two effects cause a change in the apparent binding affinity of the compound, which is indirectly assessed by cellular activity assays. To date, direct measurement of the intracellular binding affinity remains a challenging task. In this work, in-cell NMR spectroscopy was applied to measure intracellular dissociation constants in the nanomolar range by means of protein-observed competition binding experiments. Competition binding curves relative to a reference compound could be retrieved either from a series of independent cell samples or from a single real-time NMR bioreactor run. The method was validated using a set of sulfonamide-based inhibitors of human carbonic anhydrase II with known activity in the subnanomolar to submicromolar range. The intracellular affinities were similar to those obtained in vitro, indicating that these compounds selectively bind to the intracellular target. In principle, the approach can be applied to any soluble intracellular target that gives rise to measurable chemical shift changes upon ligand binding
The Transmission of Birgittine and Catherinian Works within the Mystical Tradition: Exchanges, Cross-Readings, Connections
No full textThis chapter aims to trace the role of Catherine of Siena and Birgitta of Sweden within the Observant reform. After having described the particular modes of the transmission of their mystical works, i.e. respectively the Dialogo and the Revelations, the author focuses on some significant manuscripts from the Italian peninsula and on a few key-figures, both men and women—Alfonso Pecha of Jaén, Cristoforo di Gano Guidini, Tommaso da Siena, Chiara Gambacorta, the Birgittine nuns of Paradiso in Florence and Syon in England and others— in order to demonstrate that there were a fluid context of exchanges between Birgittine and Catherinian circles
SDN for dynamic NFV deployment
No full textThis article reports a network functions virtualization proof of concept demonstrating the added value that dynamic software-defined networking control, coordinated with a flexible cloud management approach, brings to telco operators and service providers
C.A.L.M.A. Compendium Auctorum Latinorum 7.6 (2023), Iohannes Berardi - Iohannes Bertachinus · Elenchus abbreviationum · Indices
No full textFounded by Michael Lapidge and the late Claudio Leonardi, and now edited by Michael Lapidge and Francesco Santi, C.A.L.M.A. is designed to serve as a complete bibliography of medieval and humanist authors. Although various bibliographical reference-works exist for specialized disciplines (e.g. medicine) or for various religious orders (e.g. Franciscans), C.A.L.M.A. is the only reference-work which attempts coverage of all Latin authors in all disciplines and all religious orders.
For each author C.A.L.M.A. provides the following information:
First, a general bibliography (BIBL.GEN.) listing biographical and cultural studies on the author and his/her milieu, in the order of their date of publication. Under this heading are included references to entries in the relevant medieval encyclopedias (e.g. Lexikon des Mittelalters) and literary histories (e.g. Manitius), plus all relevant articles and monographs on the author;
Then follows a list of the author’s individual works (including works of doubtful authenticity), in alphabetical order. Published scholarship pertaining to each work is listed under the following headings:
REF: references to the work in alpha-numerical repertories (e.g. Bibliotheca Hagiographica Latina);
MSS: a list of the principal manuscripts which transmit the work—but these are listed only in cases where the work is unpublished, or in cases where a work is transmitted in an autograph manuscript;
ED: a list of published editions of the work (frequently including incunables);
STU: a list of the published studies—philological, historical, etc.—on the individual work
C.A.L.M.A. Compendium auctorum Latinorum Medii Aevi
No full textFounded by Michael Lapidge and the late Claudio Leonardi, and now edited by Michael Lapidge and Francesco Santi, C.A.L.M.A. is designed to serve as a complete bibliography of medieval and humanist authors. Although various bibliographical reference-works exist for specialized disciplines (e.g. medicine) or for various religious orders (e.g. Franciscans), C.A.L.M.A. is the only reference-work which attempts coverage of all Latin authors in all disciplines and all religious orders. For each author C.A.L.M.A. provides the following information: First, a general bibliography (BIBL.GEN.) listing biographical and cultural studies on the author and his/her milieu, in the order of their date of publication. Under this heading are included references to entries in the relevant medieval encyclopedias (e.g. Lexikon des Mittelalters) and literary histories (e.g. Manitius), plus all relevant articles and monographs on the author; Then follows a list of the author’s individual works (including works of doubtful authenticity), in alphabetical order. Published scholarship pertaining to each work is listed under the following headings: REF: references to the work in alpha-numerical repertories (e.g. Bibliotheca Hagiographica Latina); MSS: a list of the principal manuscripts which transmit the work—but these are listed only in cases where the work is unpublished, or in cases where a work is transmitted in an autograph manuscript; ED: a list of published editions of the work (frequently including incunables); STU: a list of the published studies—philological, historical, etc.—on the individual work
Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR
No full textCandidate drugs rationally designed in vitro often fail due to low efficacy in vivo caused by low tissue availability or because of unwanted side effects. To overcome the limitations of in vitro rational drug design, the binding of candidate drugs to their target needs to be evaluated in the cellular context. Here, we applied in-cell NMR to investigate the binding of a set of approved drugs to the isoform II of carbonic anhydrase (CA) in living human cells. Some compounds were originally developed toward other targets and were later found to inhibit CAs. We observed strikingly different dose- and time-dependent binding, wherein some drugs exhibited a more complex behavior than others. Specifically, some compounds were shown to gradually unbind from intracellular CA II, even in the presence of free compound in the external medium, therefore preventing the quantitative formation of a stable protein-ligand complex. Such observations could be correlated to the known off-target binding activity of these compounds, suggesting that this approach could provide information on the pharmacokinetic profiles of lead candidates at the early stages of multitarget drug design
Three-Dimensional Photonic Circuits in Rigid and Soft Polymers Tunable by Light
No full textPolymeric
matrices offer a wide and powerful platform for integrated
photonics, complementary to the well-established silicon photonics
technology. The possibility to integrate, on the same chip, different
customized materials allows for many functionalities, like the ability
to dynamically control the spectral properties of single optical components.
Within this context, this Article reports on the fabrication and optical
characterization of integrated photonic circuits for the telecom C-band,
made of a combination of both rigid and tunable elastic polymers.
By using a 3D photolithographic technique (direct laser writing),
in a single-step process, every building block of the polymeric circuit
is fabricated: straight and bent waveguides, grating couplers, and
single and vertically coupled whispering gallery mode resonators designed
in planar and vertical geometries. Using this platform, a new type
of operation was introduced through true three-dimensional integration
of tunable photonic components, made by liquid crystalline networks
that can be actuated and controlled by a remote and non-invasive light
stimulus. Depending on the architecture, it is possible to integrate
them as elastic actuators or as constituents of the photonic cavity
itself. The two strategies then exploit the optical induced deformation
and variation of its refractive index, inducing a net red or blue
shift of the cavity resonances, respectively. This work paves the
way for light-tunable optical networks that combine different photonic
components, made by glassy or shape-changing materials, in order to
implement further photonic circuit requirements
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