1,721,016 research outputs found
Costruzione di un percorso diagnostico, terapeutico, assistenziale per i pazienti con Sclerosi Laterale Amio-trofica in Regione Lombardia
No full textAmyotrophic Lateral Sclerosis (ALS) is a degenerative disease of the nervous system that affects selectively motor neurons
causing their death and thereby atrophy and paralysis of muscles innervated, with an invariably unfavourable prognosis.
ALS is included in the group of rare diseases (prevalence ≤50 cases per 100000 inhabitants), which have common
problems: difficulty in arriving at correct diagnosis and subsequently communicated the conclusion promptly to the patient,
complexity of care and therapeutic management of these patients. In Lombardy the attention to rare diseases is high
and in this context enter diagnostic, therapeutic and care paths drawn up by specialists. The construction of these documents
suggests an overall management of patients and their family and social context, requiring specific, passionate and
responsible resources for the practical application. The specific document for patients with ALS has these goals: use
for the disease a multidisciplinary approach, give at the patients all the available opportunities for treatment,
build provincial and regional health and social networks for the round care of patients, in order to clear the sense
of abandonment that they perceive. The patient’s perception of their quality of life is related more to the quality
of assistance received that to the severity of the disease or degree of disability associated
DNA di poliomavirus in pazienti con sclerosi multipla in terapia con Natalizumab
No full textNatalizumab therapy is associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Since the
prognosis of PML is extremely poor, identification of patients highly susceptible to the disease may improve outcomes.
Our paper tries to find out if new positive result or increased JCV DNA concentration in urine samples
may represent a good marker of viral reactivation. Secondary objectives are to assess the effects of therapy
on leucocyte serum levels and evaluate drug efficacy.
Every month, we evaluated leucocyte level, JCV and BKV DNA serum and urine concentration in 33 patient
with multiple sclerosis under Natalizumab treatment. We did not notice any variation in JCV DNA concentration,
nor new positive results. We noticed an increasing trend in the average BKV DNA concentration in urine.
Fifteen out of 33 patients were treated for a period of 12 months. In this subgroup we noticed an increasing trend
in leucyte serum levels and a BKV DNA new positive result in urine sample. After one year patients showed a
significant decrease in relapse rate compared to the previous year and an improvement in EDSS.
Monitoring urine JCV DNA concentration does not seem an effective marker for viral reactivation. A
good marker could be BKV DNA urine level
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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