50 research outputs found
Ethos Presenza Storia: la ricerca filosofica di Ernesto De Martino
No full textSergio Fabio Berardini ha scelto di concentrare il proprio interesse scientifico sul versante squisitamente antropologico del pensiero di De Martino, sottoponendo ad un esame accurato e penetrante la nozione di “ethos trascendentale del trascendimento”: «ethos specificamente e uni-versalmente umano che è trascendimento della vita secondo valorizzazioni comunitarie e tendenzialmente intersoggettive». Si tratta di una nozione-chiave, ricca d’implicazioni di estrema importanza, senza la quale l’intero ‘edificio’ costruito da De Martino risulta inafferrabile nella sua effettiva complessità: per metterne a fuoco il significato d’insieme e le molteplici sfaccettature, Berardini si è addentrato con perizia nell’analisi delle moderne correnti filosofiche europee e italiane. Il risultato è un quadro affascinante, di notevole pregio, sostenuto da una scrittura elegante, immune da tecnicismi gratuiti, dal quale affiora l’originalità del pensiero demartiniano.
(dalla Prefazione di Marcello Massenzio
Antithrombotic Management during Percutaneous Mitral Valve Repair with the Mitraclip System in a Patient with Heparin-Induced Thrombocytopenia
No full textInterventional cardiology procedures require full anticoagulation to prevent thrombus formation on catheters and devices with potential development of embolic complications. Bivalirudin, a short half-life direct thrombin inhibitor, has been largely used during percutaneous coronary interventions and represents the preferred alternative to heparin in patients with heparin-induced thrombocytopenia (HIT). However, few data are available about intraprocedural use of bivalirudin during transcatheter structural heart disease interventions. Activated clotting time (ACT) monitoring during bivalirudin infusion pre- sents some limitations and it is not mandatory. We report a case of bivalirudin use in a patient with type-2 HIT during percutaneous mitral valve repair with the Mitraclip system (Abbott, Abbott Park, Illinois, United States). Despite use of standard bivalirudin dose (0.75 mg/kg bolus and 1.4 mg/kg/min infusion—reduced infusion rate was motivated by a glomerular filtration rate of 37 mL/min), the patient developed a large thrombus on the second clip during its orientation toward the mitral orifice. ACT was measured at that time and was suboptimal (240 seconds). The case was successfully managed with clip and thrombus retrieval, adjunctive 0.3 mg/kg bivalirudin bolus and increased infusion rate, and clip repositioning with ACT monitoring. This report makes the case for mandatory ACT checking and drug titration during high-risk catheter–based structural heart disease interventions, even when thromboprophylaxis is performed with bivalirudin. Additional coagulation tests may be useful to monitor bivalirudin response in similar cases
“Amori et dolori sacrum”: canons, differences and figures of gender identity in the cultural panorama of travellers in Capri between the Nineteenth and Twentieth centuries
No full textFrom an anthropological perspective the author deals with island of Capri as a cultural object. A sea resort since Roman times, a splendid gem of the Mediterranean, Capri was a playground not only for rich Germans and British looking for sexual adventures; it was also the place where genders were perpetually looking for a definite fixation, or identity. The author demonstrates well the ambiguity of the local population, vis-à-vis foreigners, and amongst themselves. In this essay, the links between aesthetic and the erotic strongly surface. The same idea of “beauty” has several applications, and as many nuances
Il fragore della battaglia. I Sindacati della critica cinematografica in Italia attraverso la stampa d’epoca
No full textThroughout the twentieth century, Italian film criticism ran into various moments of crisis; three of these triggered the foundation of a union organization, a political instrument with little affinity for the intellectual elites and yet cyclically present in the history of our criticism. The years in question are 1916, 1925 and 1971, to which we owe, respectively, the Syndicate of the Film Press, the Syndicate of Intellectuals of Cinematography and the National Syndicate of Italian Film Critics. They are profoundly different moments and in any case in dialogue with each other, as phases of an identity repositioning in which the professional and ideological, political and social levels intersect. The aim of this essay is therefore to recover the studies that interpret the discursive practice of criticism as an entity ontologically connected to a state of crisis (de Man, Frey) to place them in a more accentuated historical framework. To do so, the three quoted periods will be reconstructed and analysed, using an archival corpus of period press as sources, and the cultural industry as an additional theoretical framework in the context of Italian literary theory of the sixties (Ferretti, Fortini), in order to restore facets and complexities of crisis that would otherwise not be resolved in purely endemic and ontological terms.Lungo il Novecento la critica cinematografica italiana è incorsa in diversi momenti di crisi; tre di questi hanno innescato la fondazione di un’organizzazione sindacale di categoria, strumento politico poco affine alle élite intellettuali eppur ciclicamente presente nella storia della nostra critica. Gli anni in oggetto sono il 1916, 1925 e 1971, cui si devono, rispettivamente, il Sindacato della Stampa Cinematografica, il Sindacato degli Intellettuali della Cinematografia e il Sindacato Nazionale Critici Cinematografici Italiani. Sono momenti profondamente diversi e comunque dialoganti tra loro, in quanto fasi di un riposizionamento identitario nel quale s’intersecano i piani del professionale e dell’ideologico, del politico e del sociale. Obiettivo di questo saggio è quindi quello di recuperare gli studi che interpretano la pratica discorsiva della critica come entità ontologicamente connessa a uno stato di crisi (de Man, Frey) per calarli in una più accentuata cornice storica. Per farlo si andrà a ricostruire e analizzare i tre passaggi citati, utilizzando come fonti un corpus archivistico di stampa d’epoca, e come framework teorico aggiuntivo l’industria culturale nel contesto della teoria letteraria italiana degli anni sessanta (Ferretti, Fortini), al fine di restituire sfaccettature e complessità di snodi altrimenti non risolvibili in termini unicamente endemici e ontologici
Aeroacoustics of Transonic Shock-Boundary Layer Interactions
No full textThe interaction of a spatially developing supersonic turbulent boundary layer with a normal shock wave is analyzed by means of direct numerical simulation of the compressible Navier-Stokes equations. At the selected flow conditions, corresponding to a mild shock, no mean flow separation is observed. However, the flow is strongly unsteady, and inter- mittent regions of flow reversal are found near the wall, while large vortical structures are observed away from it. Such structures are mainly responsible for the amplification of noise and turbulence across the interaction zone. The intense acoustic loads occurring in the interaction zone are found to be strictly related to the Reynolds shear stress distribu- tion. The analysis of the pressure energy spectra shows a behavior consistent with that observed in incompressible boundary layers in adverse pressure gradient. In particular, a power-law scaling is recovered: at low frequencies the spectra scale as St0.4, while at high frequencies they decay as St-5. The results show that the interacting shock primarily acts as a low-pass filter for the turbulence spectra. © 2007 by Sergio Pirozzoli and Francesco Grasso
Profiniteness, monadicity and universal models in modal logic
No full textTaking inspiration from the monadicity of complete atomic Boolean algebras, we prove that profinite modal algebras are monadic over Set. While analyzing the monadic functor, we recover the universal model construction - a construction widely used in the modal logic literature for describing finitely generated free modal algebras and the essentially finite generated subframes of their canonical models. (c) 2024 Elsevier B.V. All rights reserved
Digital Terrain Model (DTM) morphometry of sinuous pit chains and atypical pit craters related to colossal inflated lava tubes on Mars
No full textClinical presentations leading to arrhythmogenic left ventricular cardiomyopathy
No full textOBJECTIVES: To describe a cohort of patients with arrhythmogenic left ventricular cardiomyopathy (ALVC), focusing on the spectrum of the clinical presentations. METHODS: Patients were retrospectively evaluated between January 2012 and June 2020. Diagnosis was based on (1) ≥3 contiguous segments with subepicardial/midwall late gadolinium enhancement in the left ventricle (LV) at cardiac magnetic resonance plus a likely pathogenic/pathogenic arrhythmogenic cardiomyopathy (AC) associated genetic mutation and/or familial history of AC and/or red flags for ALVC (ie, negative T waves in V4-6/aVL, low voltages in limb leads, right bundle branch block like ventricular tachycardia) or (2) pathology examination of explanted hearts or autoptic cases suffering sudden cardiac death (SCD). Significant right ventricular involvement was an exclusion criterion. RESULTS: Fifty-two patients (63% males, age 45 years (31–53)) composed the study cohort. Twenty-one (41%) had normal echocardiogram, 13 (25%) a hypokinetic non-dilated cardiomyopathy (HNDC) and 17 (33%) a dilated cardiomyopathy (DCM). Of 47 tested patients, 29 (62%) were carriers of a pathogenic/likely pathogenic DNA variant. Clinical contexts leading to diagnosis were SCD in 3 (6%), ventricular arrhythmias in 15 (29%), chest pain in 8 (15%), heart failure in 6 (12%) and familial screening in 20 (38%). Thirty patients (57%) had previously received a diagnosis other than ALVC with a diagnostic delay of 6 years (IQR 1–7). CONCLUSIONS: ALVC is hidden in different clinical scenarios with a phenotypic spectrum ranging from normal LV to HNDC and DCM. Ventricular arrhythmias, chest pain, heart failure and SCD are the main clinical presentations, being familial screening essential for the affected relatives’ identification
Modifications of medical treatment and outcome after percutaneous correction of secondary mitral regurgitation
No full textAims: The optimization of guideline-directed medical therapy (GDMT) in reduced ejection fraction heart failure (HFrEF) is associated with improved survival and can reduce the severity of secondary mitral regurgitation (SMR). Highest tolerated doses should be achieved before percutaneous mitral valve repair (pMVR) and drugs titration further pursued after procedure. The degree of GDMT titration in patients with HFrEF and SMR treated with pMVR remains unexplored. We sought to evaluate the adherence to GDMT in HFrEF in patients undergoing pMVR and to explore the association between changes in GDMT post-pMVR and prognosis.
Methods and results: We included all the patients with HFrEF and SMR ≥ 3 + treated with pMVR between 2012 and 2019 and with available follow-up. GDMT, comprehensive of dosages, was systematically recorded. The study endpoint was a composite of death and heart transplantation. Among 133 patients successfully treated, 121 were included (67 ± 12 years old, 77% male patients). Treatment rates of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor neprilysin inhibitor (ACEIs/ARBs/ARNI), beta-blockers, and mineralcorticoid receptor antagonist at baseline and follow-up were 73% and 79%, 85% and 84%, 70% and 70%, respectively. At baseline, 33% and 32% of patients were using >50% of the target dose of ACEI/ARB/ARNI and beta-blockers. At follow-up (median time 4 months), 33% of patients unchanged, 34% uptitrated, and 33% of patients downtitrated GDMT. Downtitration of GDMT was independently associated with higher risk of death/heart transplantation (hazard ratio: 2.542, 95%confidence interval: 1.377-4.694, P = 0.003).
Conclusions: Guideline-directed medical therapy is frequently underdosed in HFrEF patients with SMR undergoing pMVR. Downtitration of medications after procedure is associated with poor prognosis
Repeated Aortic Balloon Valvuloplasty in Elderly Patients With Aortic Stenosis Who Are Not Candidates for Definitive Treatment
No full textA sizable group of patients with symptomatic aortic stenosis can undergo neither surgical aortic valve replacement nor transcatheter aortic valve implantation. The aim of this study was to assess the potential role of repeated balloon aortic valvuloplasty (BAV) in these patients
