1,721,082 research outputs found
Tecniche spettrometriche applicate alla valutazione dell'esposizione della popolazione ad elementi in traccia
Full text linkLe attività sono state finalizzate, nelle loro diverse articolazioni, all’implementazione di nuovi criteri e metodologie di biomonitoraggio per la valutazione dell’esposizione ad elementi in traccia di diversi gruppi di popolazione.
È stata valutata l’esposizione professionale ad elementi del gruppo del platino (palladio, platino e rodio) mediante un approccio innovativo ICP-MS, basato su un rivelatore ad alta risoluzione (SF-ICP-MS), proposti come efficaci biomarcatori di esposizione per popolazioni professionalmente esposte a traffico veicolare.
È stato inoltre sviluppato e validato un metodo analitico multielementare SF-ICP-MS altamente sensibile e specifico ad elevata produttività per la determinazione di oltre venti elementi in traccia nel sangue; il metodo è stato applicato alla definizione di valori di riferimento della popolazione generale per il biomonitoraggio per i metalli.
Parallelamente, sono state condotte indagini sperimentali nell’ambito dello screening di patologie neoplastiche, in particolare approfondendo il valore predittivo di elementi chimici tossicologicamente significativi nella diagnosi precoce del tumore del colon-retto. I risultati hanno evidenziato una probabile correlazione inversa tra livelli di Ba, Cd e Hg ed insorgenza di lesioni, e confermato la tendenza ad accumulo di Fe e Se nei tessuti patologici.
L’ultima fase delle ricerche, attualmente in corso, ha per oggetto l’elaborazione di metodi di screening e conferma, rispettivamente mediante sensori elettrochimici e SF-ICP-MS, applicati allo studio dell’esposizione - attraverso il latte materno - di gruppi sensibili di popolazione (neonati) ad un elemento neurotossico come il piombo.
I modelli sperimentali, verificati in settori differenti e complessi nel corso delle ricerche di tesi, hanno dimostrato notevoli potenzialità applicative e particolare versatilità. Possono essere pertanto proposti come approccio innovativo per l’implementazione di programmi di biomonitoraggio e per la definizione di strategie di prevenzione primaria del rischio correlato ad elementi in traccia a tutela della salute umana.The activities were finalized, in their different articulations, to the implementation of new criteria and methods of biomonitoring for the assessment of exposure to trace elements of different population groups.
At first the occupational exposure to the elements of the platinum group (palladium, platinum and rhodium) was evaluated by an innovative ICP-MS approach based on a high resolution detector (SF-ICP-MS). These elements has been proposed as effective biomarkers of exposure for populations occupationally exposed to vehicular traffic.
Furthermore a sensitive, specific, multielemental and high-throughput analytical SF-ICP-MS method was developed and validated for the simultaneous determination of 20 trace elements in human blood, the method was then applied for setting reference values for trace elements in the general population.
Moreover, surveys were conducted in the experimental screening of neoplastic diseases, in particular studying the predictive value of toxicologically important trace elements in the early detection of colorectal cancer. The results showed a probable inverse relationship between levels of Ba, Cd and Hg, and outbreaks of lesions, and confirmed the trend towards accumulation of Fe and Se in pathological tissues.
The last phase of the study, currently in progress, is based on the development of methods of screening and confirmation, respectively through electrochemical sensors and SF-ICP-MS, applied for the study of the exposure - through the breast milk - of a sensitive group of population (newborns) to a neurotoxic element as lead.
The experimental models developed during the thesis work, were verified in different research areas and showed elevated application power and particular versatility. The proposed analytical methods can therefore be proposed as innovative approach for the implementation of biomonitoring programs and strategies for primary prevention of risk related to trace elements for human health protection
Microplastics in water. Sampling, Sample treatment and Analysis. TAIEX Study Visit on Environmental and health risks of microplastic pollution
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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