177,024 research outputs found
Strangling technique to treat large cervicofacial venous malformations: A preliminary report
No full textBackground. Surgical removal of large cervicofacial venous malformations might be hampered by massive intraoperative bleeding. Moreover, these lesions often insinuate within normal surrounding tissue, making complete resection impossible without causing significant morbidity. Methods. Two patients affected by facial venous malformations nonresponsive to sclerotherapy underwent surgery. Bleeding and critical branching of the facial nerve within the lesion prevented the surgeons from proceeding with the removal. The unresectable malformation was decompressed by means of a number of nonresorbable stitches from the surface of the lesion to the periosteum, tailoring a permanent pressure dressing. Results. Outcomes at 12-month follow-up were stable, with good cosmetic results and satisfaction reported by both patients. No long-term side effects related to the procedure were observed. Conclusion. Decompression of large venous malformations by means of a strangling technique might represent a safe and effective procedure for those cases where a removal cannot be accomplished
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Il ruolo dei farmaci antiangiogenetici nella gestione delle malformazioni artero-venose del distretto testa-collo
No full textLe malformazioni arterovenose (MAV) sono malformazioni ad alto flusso in cui una rete complessa di vasi mette in comunicazione diretta afferenze arteriose e drenaggio venoso. Le MAV vanno solitamente incontro a progressione nel corso della vita, mentre le regressioni spontanee documentate sono sostanzialmente eccezionali.
Le MAV sono estremamente aggressive e possiedono una capacità infiltrativa locale che ricorda quella delle neoplasie maligne. La resezione chirurgica “radicale” garantisce le più elevate possibilità di cura, ma non vi è unanimità sulla gestione delle MAV di dimensioni maggiori che non possono essere rimosse in modo completo.
Scopo di questa presentazione è quello di proporre un approccio differente al trattamento delle MAV di grosse dimensioni non candidabili alla resezione radicale.
L’associazione di farmaci antiangiogenetici (che deve iniziare prima della chirurgia e proseguire nel periodo postoperatorio) potrebbe avere un ruolo chiave nel prevenire la tanto temuta crescita “esplosiva” del nidus rimanente a fronte di un’asportazione parziale. Questo approccio potrebbe rendere possibile realizzare per questi pazienti recontouring e altre procedure più “orientate all’estetica”, con un ovvio miglioramento della qualità di vita.
Il più promettente tra i farmaci antiangiogenetici sembra essere la Talidomide, anche se altri farmaci come Sirolimus, inibitori della via di VEGF, interferoni e inibitori delle metalloproteinasi potrebbero rivelarsi altrettanto utili. Anche il propanololo potrebbe avere un ruolo simile, come sembrano indicare alcune recenti scoperte nel campo della retinopatia del prematuro e dell’oncobiologia
Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam
No full textThe aim of this study was to evaluate complications in patients with head and neck venous malformations (VMs) treated with foam sclerotherapy using sodium tetradecyl sulfate (STS)
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Occlusion of an intraosseous arteriovenous malformation with percutaneous injection of polymrthylmethacrylate
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Sclerotherapy of peripheral vanous malformations: a new technique to prevent serious complications
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