2,463 research outputs found
The chronicle of Alfonson lll and its significance for the historiography of the Asturian kingdom 718-910 AD
No full textThe Asturian kingdom provided the earliest organised
resistance in the Iberian peninsula to the Muslim invaders who overthrew the Visigothic state at the start of the 8th century. Information on the origins of the Asturian kingdom is regrettably sparse. Historians of the kingdom are totally reliant on a late 9th-century cycle of Asturian chronicles associated with the royal court, the most substantial of which is the Chronicle of Alfonso III. This work has survived in two fundamental recensions from the 10th century. Historians' gratitude for its existence is tinged with frustration at its readily apparent weaknesses, such as a chronological imprecision on events and an enigmatic brevity in the commentary.
This thesis considers the 9th-century Asturian chronicles in
the context of their own time. In particular, it examines the Chronicle of Alfonso III not as a disappointing source which fails to yield to modern scholars the information they crave on this obscure period of early Spanish history, but, rather, as an expression of the aims of a medieval author and his copyists. The Chronicle was the product of scarce and valuable resources. Its author, within the limits of his literary ability and source of information, transmitted a message which interacted with the individual understanding of its intended audience. This shift of
emphasis in analysing the Chronicle of Alfonso III rests on the assumption that its original text may be recognised in the later recensions which used it, by addition or omission, as a vehicle for their own interests
TARGETING TYR682 RESIDUE ON THE AMYLOID PRECURSOR PROTEIN FOR THE DEVELOPMENT OF DIAGNOSTIC AND THERAPEUTIC STRATEGIES IN ALZHEIMER'S DISEASE
No full textNumerical Simulation of Liquid-structure Interaction Problem in a Tank of a Space Re-entry Vehicle
No full textNon
TNF-α Levels Are Increased in Patients with Subjective Cognitive Impairment and Are Negatively Correlated with β Amyloid-42
No full textThe role of tumor necrosis factor-α (TNF-α) in Alzheimer’s disease (AD) has recently become a topic of debate. TNF-α levels increase in the blood of patients with AD, and amyloid beta (Aβ) plaques contain TNF-α deposits. The therapeutic efficacy of blocking TNF-α in patients with AD remains controversial as it is mostly based on preclinical studies. Thus, whether and how TNF-α contributes to amyloidogenic processes in AD is still an open question to be addressed. We analyzed plasma TNF-α and Aβ42 levels in patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and AD, and in healthy volunteers (HLT). In addition, we performed correlation analysis to evaluate whether changes in plasma TNF-α levels correlate with cognitive decline, Aβ42 levels, age, and BMI, which are all factors considered to contribute to or predispose individuals to AD. We found that TNF-α and Aβ42 plasma levels were higher in patients with AD than in HLT individuals. High TNF-α levels were also observed in patients with SCI, in whom TNF-α and Aβ42 levels were negatively correlated. Notably, TNF-α did not affect the amyloidogenic pathway in human microglial cultures exposed to 48 h of incubation, although it did trigger neuroinflammatory processes. These results imply that high TNF-α levels are more likely to be a clinical condition linked to AD than are direct contributors. Nonetheless, elevated levels of TNF-α in early-stage patients, like those with SCI and MCI, may provide a distinguishing feature for identifying clinical profiles that are at risk of having a poorer outcome in AD and could benefit from tailored therapies
Alfonso Garcia Valdecasas Garcia Valdecasas - vita e opera
No full textLa presente tesis doctoral tiene por objetivo analizar la obra y el pensamiento de Alfonso Garcia Valdecasas y Garcia Valdecasas. El estudio se encuadra en el área del derecho romano puesto que él comenzó su carrera como iusromanista, doctorándose en Bolonia como colegial del Real Colegio de España con una tesis dirigida por Emilio Costa. Aquel trabajo recibió el premio Vittorio Emanuele Secondo y, tal y como se demostrará, fue el primer trabajo estrictamente científico de la romanística hispana moderna. Otras publicaciones del autor que se incluyen en el presente trabajo permitirán trazar las líneas del pensamiento jurídico, filosófico y –en parte- político de Alfonso Garcia Valdecasas y Garcia Valdecasas.This PhD thesis aims at analyzing both the work and the thought of Alfonso Garcia-Valdecasas Garcia-Valdecasas. The study is in the field of roman law due to the fact that he started his career as a iusromanist, receiving his PhD in Bologna as a collegiate of the Royal Spanish College with a thesis under the supervision of Professor Emilio Costa. That piece received the Vittorio Emanuele II price and, as it will be demonstrated, it represents the first purely scientific work in the modern hispanic roman law science. Other publications by the author included in this very work will allow to outline the traits of the legal, philosophical and -partly- political thought of Alfonso Garcia-Valdecasas Garcia-Valdecasas.Questa tesi di dottorato ha per obbiettivo analizzare l’opera e il pensiero di Alfonso Garcia-Valdecasas y Garcia-Valdecasas. Lo studio si presenta nell’area del diritto romano poiché egli inizió la sua traiettoria come iusromanista, dottorandosi a Bologna come collegiale del Collegio di Spagna, con una tesi diretta da Emilio Costa. Quel lavoro ricevette il Premio Vittorio Emanuele II e, come si mostrerá, rappresenta il primo lavoro prettamente scientifico della romanistica ispanica moderna. Altre pubblicazioni dell’autore incluse nel presente lavoro permetteranno di delineare i tratti del pensiero giuridico, filosofico e –in parte- político di Alfonso Garcia Valdecasas y Garcia Valdecasas
Advances in peripheral blood biomarkers of patients with Alzheimer’s disease: Moving closer to personalized therapies
No full textRecently, measurable peripheral biomarkers in the plasma of patients with Alzheimer's disease (AD) have gained considerable clinical interest. Several studies have identified one or more blood signatures that may facilitate the development of novel diagnostic and therapeutic strategies. For instance, changes in peripheral amyloid β42 (Aβ42) levels have been largely investigated in patients with AD and correlated with the progression of the pathology, although with controversial results. In addition, tumor necrosis factor α (TNFα) has been identified as an inflammatory biomarker strongly associated with AD, and several studies have consistently suggested the pharmacological targeting of TNFα to reduce systemic inflammation and prevent neurotoxicity in AD. Moreover, alterations in plasma metabolite levels appear to predict the progression of systemic processes relevant to brain functions. In this study, we analyzed the changes in the levels of Aβ42, TNFα, and plasma metabolites in subjects with AD and compared the results with those in healthy elderly (HE) subjects. Differences in plasma metabolites of patients with AD were analyzed with respect to Aβ42, TNFα, and the Mini-Mental State Examination (MMSE) score, searching for plasma signatures that changed simultaneously. In addition, the phosphorylation levels of the Tyr682 residue of the amyloid precursor protein (APP), which we previously proposed as a biomarker of AD, were measured in five HE and five AD patients, in whom the levels of Aβ42, TNFα, and two plasma lipid metabolites increased simultaneously. Overall, this study highlights the potential of combining different plasma signatures to define specific clinical phenotypes of patient subgroups, thus paving the way for the stratification of patients with AD and development of personalized approaches
Alfonso Shimbel, 1953, Structural Parameters of Communication Networks. Version bilingue et commentée
No full textShimbel, Alfonso. "Structural parameters of communication networks." The bulletin of mathematical biophysics 15 (1953): 501-507.This document of the group fmr presents a bilingual (English-French) and commented version of Alfonso Shimbel's article, Structural Parameters of Communication Networks, published in 1953 in the Bulletin of Mathematical Biophysics. The author pursues the avenues explored in his 1951 article (Application of Matrix Algebra to Communications Nets) and proposes various measures for qualifying a communications network. The indicators of dispersion and accessibility will be widely used, particularly in transport geography.Ce document du groupe fmr présente une version bilingue et commentée de l'article d'Alfonso Shimbel, Structural Parameters of Communication Networks, paru en 1953 dans la revue Bulletin of Mathematical Biophysics. L'auteur poursuit les pistes explorées dans son article de 1951 (Application of Matrix Algebra to Communications Nets) et propose différentes mesures permettant de qualifier un réseau de communication. Les indicateurs de dispersion et d'accessibilité seront largement repris, notamment en géographie des transports
Alfonso Shimbel, 1953, Structural Parameters of Communication Networks. Version bilingue et commentée
No full textShimbel, Alfonso. "Structural parameters of communication networks." The bulletin of mathematical biophysics 15 (1953): 501-507.This document of the group fmr presents a bilingual (English-French) and commented version of Alfonso Shimbel's article, Structural Parameters of Communication Networks, published in 1953 in the Bulletin of Mathematical Biophysics. The author pursues the avenues explored in his 1951 article (Application of Matrix Algebra to Communications Nets) and proposes various measures for qualifying a communications network. The indicators of dispersion and accessibility will be widely used, particularly in transport geography.Ce document du groupe fmr présente une version bilingue et commentée de l'article d'Alfonso Shimbel, Structural Parameters of Communication Networks, paru en 1953 dans la revue Bulletin of Mathematical Biophysics. L'auteur poursuit les pistes explorées dans son article de 1951 (Application of Matrix Algebra to Communications Nets) et propose différentes mesures permettant de qualifier un réseau de communication. Les indicateurs de dispersion et d'accessibilité seront largement repris, notamment en géographie des transports
Alfonso Shimbel, 1951, Applications of Matrix Algebra to Communication Nets. Version bilingue et commentée
No full textShimbel, Alfonso. "Applications of matrix algebra to communication nets." The bulletin of mathematical biophysics 13 (1951): 165-178.This document of the group fmr presents a bilingual (English-French) and commented version of Alfonso Shimbel's article, Applications of Matrix Algebra to Communication Nets, published in 1951 in the Bulletin of Mathematical Biophysics. The author relies on recent work in matrix analysis to propose different measures that can qualify the structure of a communication network. This article serves as a methodological basis for the 1953 article by the same author entitled Structural Parameters of Communication Networks. Although Shimbel never mentions graph theory, several of his proposals have direct applications in network analysis.Ce document du groupe fmr présente une version bilingue et commentée de l'article d'Alfonso Shimbel, Applications of Matrix Algebra to Communication Nets, paru en 1951 dans la revue Bulletin of Mathematical Biophysics. L'auteur s'appuie sur des travaux récents d'analyse matricielle pour proposer différentes mesures susceptibles de qualifier la structure d'un réseau de communication. Cet article sert de base méthodologique à l'article de 1953 du même auteur intitulé Structural Parameters of Communication Networks. Si Shimbel n'évoque à aucun moment la théorie des graphes, plusieurs de ses propositions trouvent des applications directes en analyse de réseau
Alfonso Shimbel, 1951, Applications of Matrix Algebra to Communication Nets. Version bilingue et commentée
No full textShimbel, Alfonso. "Applications of matrix algebra to communication nets." The bulletin of mathematical biophysics 13 (1951): 165-178.This document of the group fmr presents a bilingual (English-French) and commented version of Alfonso Shimbel's article, Applications of Matrix Algebra to Communication Nets, published in 1951 in the Bulletin of Mathematical Biophysics. The author relies on recent work in matrix analysis to propose different measures that can qualify the structure of a communication network. This article serves as a methodological basis for the 1953 article by the same author entitled Structural Parameters of Communication Networks. Although Shimbel never mentions graph theory, several of his proposals have direct applications in network analysis.Ce document du groupe fmr présente une version bilingue et commentée de l'article d'Alfonso Shimbel, Applications of Matrix Algebra to Communication Nets, paru en 1951 dans la revue Bulletin of Mathematical Biophysics. L'auteur s'appuie sur des travaux récents d'analyse matricielle pour proposer différentes mesures susceptibles de qualifier la structure d'un réseau de communication. Cet article sert de base méthodologique à l'article de 1953 du même auteur intitulé Structural Parameters of Communication Networks. Si Shimbel n'évoque à aucun moment la théorie des graphes, plusieurs de ses propositions trouvent des applications directes en analyse de réseau
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