67 research outputs found
"Presentación del libro de José M. Sevilla Prolegómenos para una crítica de la razón problemática. Motivos en Vico y Ortega"
Get PDFPresentación realizada en español por el autor, en la Universidad de Sevilla el día 6 de junio de 2011, en el acto de presentación conjunta de los libros Prolegómenos para una crítica de la razón problemática. Motivos en Vico y Ortega (José M. Sevilla) y Filosofía de la razón plural. Isaiah Berlin entre dos siglos (Pablo Badillo O’Farrell, Coord.); acto en el que participaron los profesores Joaquín Abellán, Pablo Badillo, Giuseppe Cacciatore, José M. Sevilla y Fulvio Tessitore.Presentation read in Spanish by the author in the joint launching of the books Prolegómenos para una crítica de la razón problemática. Motivos en Vico y Ortega (José M. Sevilla) and Filosofía de la razón plural. Isaiah Berlin entre dos siglos (Pablo Badillo O’Farrell, Coord.) that took place at the University of Seville on June the 6th, 2011. The act counted with the participation of Joaquín Abellán, Pablo Badillo, Giuseppe Cacciatore, José M. Sevilla and Fulvio Tessitore
Il Kant di Croce
Get PDFIn this speech to the Academia dei Lincei in Rome, Giuseppe Cacciatore sketches the role Kant played in Croce’s historicism. Surprisingly, this topic has been little investigated up to now, although Kant is a decisive source for Croce’s thought.The paper concentrates on the main Kantian passages in Croce’s writings, and shows similarities and differences between the two thinkers as to the function of “category”. On this basis, the Author raises the issue: how much tied to Kantian “Ich” is Croce’s post-Hegelian subject
Pathology of non-alcoholic fatty liver disease
Get PDFNon-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of different conditions which are characterized by hepatic steatosis in the absence of secondary causes. It is currently the most common chronic liver disease worldwide, and its estimated prevalence is about 1.5-6.5%. The only histological finding of steatosis ("simple" steatosis) represents the uncomplicated form of NAFLD, while non-alcoholic steatohepatitis (NASH) is its inflammatory subtype associated with disease progression to cirrhosis and hepatocellular carcinoma (HCC), and represents the major indication for liver transplantation. NASH is still a diagnostic and therapeutic challenge for clinicians and liver biopsy is currently the only accepted method to reliably distinguish NASH from "simple" steatosis. From the histological perspectives, NAFLD and NASH continue to be an area of active interest for pathologists, with a specific focus on better methods of evaluation, morphologic clues to pathogenesis, and predictors of fibrosis progression. This review focuses on histopathology of NAFLD in adults, with the aim to provide a practical diagnostic approach useful in the clinical routine
Storicismo e filosofia pratica: G. Cacciatore interprete di Croce
No full textIn this essay, the author attempts to trace the entire path of the reading provided by Giuseppe Cacciatore on the work of Croce. The subject is particularly meaningful as it allows to deal with an interpretation of the views elaborated by Croce among the “problematic historicism”, thus on a distinct critic orientation, other than the positions of the philosopher of Pescasseroli, but, still, able to tickle an analysis – still to be deepened – on the relation between them. Following this perspective, the main themes of the Practical Philosophy, and Civil Philosophy and of the Criticism on finalism emerge
Proinsulin-expressing dendritic cells in type 2 neuropathic diabetic patients with and without foot lesions
No full textDiabetic neuropathy is the most common complication of diabetes and is frequently associated with foot ischemia and infection, but its pathogenesis is controversial. We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions. We assessed proinsulin expression by using flow cytometry in dendritic cells from control participants and patients with type 2 diabetic with or without peripheral neuropathy or accompanied by diabetic foot. Among 32 non-neuropathic and 120 neuropathic patients with type 2 diabetic, we performed leg electromyography and found average sensory sural nerve conduction velocities of 48 ± 4 and 30 ± 4 m/s, respectively ( P < 0.03). Of those with neuropathy, 42 were without lesions, 39 had foot lesions, and 39 had neuroischemic foot lesions (allux oximetry <30 mmHg). In this well-defined diabetic population, but not in nondiabetic participants, a progressively increasing level of peripheral blood dendritic cell proinsulin expression was detected, which directly correlated with circulating TNF-α levels ( P < 0.002) and multiple conduction velocities of leg nerves ( P < 0.05). These results are consistent with the hypothesis that, in type 2 diabetes, proinsulin-expressing blood cells, possibly via their involvement in innate immunity, may play a role in diabetic peripheral neuropathy and foot lesions.-Sambataro, M., Sambado, L., Trevisiol, E., Cacciatore, M., Furlan, A., Stefani, P. M., Seganfreddo, E., Durante, E., Conte, S., Della Bella, S., Paccagnella, A., dei Tos, A. P. Proinsulin-expressing dendritic cells in type 2 neuropathic diabetic patients with and without foot lesions
A parafoveal retinal cones analysis using adaptive-optics retinal camera in patients with primary open angle glaucoma
Get PDFObjectives: To study the density, spacing, and regularity of retinal cone photoreceptors using an Adaptive Optics (AO) retinal camera (Rtx1TM, Imagine Eyes, Orsay, France) in patients with Primary Open Angle Glaucoma (POAG) and to compare the outcomes with those of healthy age-matched control subjects. Methods: The study included 43 eyes with POAG and 31 eyes of normal subjects. POAG patients were divided into three groups according to the severity of the visual field defect. The AO Rtx1TM was used to obtain images of the parafoveal cone mosaic to calculate cone values. Analysis was performed at two and four degrees of eccentricity from the fovea along the four meridians (nasal, temporal, superior, inferior). Results: In POAG eyes, the mean ± standard deviation (SD) cone density at 2° considering all meridians was significantly lower than in normal controls (23,058.6 ± 3532.0 cones/mm2, and 25,511.7 ± 3157.5 cones/mm2, respectively; p = 0.003). Cone spacing was 7.3 ± 0.5 μm in POAG and 7.0 ± 0.4 μm in normal controls (p = 0.005), and cone regularity was 90.5 ± 4.9% and 93.5 ± 1.9% in POAG and normal controls, respectively (p < 0.001). At 4° similar trends were observed. However, no significant differences were found among patients with different severity of POAG (p > 0.05). Conclusions: Using AO Rtx1TM, significant differences in retinal photoreceptors mosaic pattern were found between POAG eyes and age-matched controls, indicating a reduction in photoreceptors in POAG. No significant differences in retinal photoreceptor values were found among the three POAG groups
Pathology of autoimmune hepatitis
No full textAutoimmune hepatitis (AIH) is a relatively rare non-resolving chronic liver disease, which mainly affects women. It is characterized by hypergammaglobulinemia, circulating autoantibodies, interface hepatitis on liver histology and a favourable response to immunosuppression. The putative mechanism for the development of autoimmune hepatitis is thought to be the interaction between genetic predisposition, environmental triggers and failure of the native immune system.AIH still remains a major diagnostic and therapeutic challenge, mainly because it is a very heterogeneous disease. Prompt and timely diagnosis is crucial since, if left untreated, AIH has a high mortality rate. Histological demonstration of hepatitis is required for the diagnosis of AIH and, therefore, liver biopsy is mandatory in the initial diagnostic work-up, before treatment. In this review, we summarize the histological features of AIH with the main aim of highlighting the most important clinical-pathological hallmarks useful in the routine diagnostic practice
Splenic littoral cell hemangioendothelioma in a patient with crohn's disease previously treated with immunomodulators and anti-TNF agents: A rare tumor linked to deep immunosuppression
Get PDFTh e risk of malignancy in Crohn ’ s disease (CD) has been well described. Moreover, immunomodulators, uch as azathioprine (AZA) and 6-mercaptopurine (6-MP), and biological agents,
such as infl iximab and adalimumab, may promote carcinogenesis ( 1 – 3 ). Splenic littoral cell tumors are recently described tumors of vascular origin composed of endothelial cells, with typical microscopic and immunohistochemical features of splenic sinus lining cells ( 4 ). Clinical findings are not specific,
and outcome is unpredictable but usually benign, although a few cases with a malignant behavior have been reported ( 5,6 ). We report a 58-year-old Caucasian man with a long history of ileocolonic CD
Pyogenic granuloma-like Kaposi's sarcoma' on the hands: immunohistochemistry and human herpesvirus-8 detection
No full textLetter to Edito
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