116 research outputs found
Dataset for Chanvin, M., Lamarque, F., Diko, N., Agil, M., Micheletta, J., Widdig, A. (2023). Ten years of positive impact of a conservation education program on children's knowledge and behaviour towards crested macaques (Macaca nigra) in the Greater Tangkoko Area, North Sulawesi, Indonesia. International Journal of Primatology.
No full textDataset for Chanvin, M., Lamarque, F., Diko, N., Agil, M., Micheletta, J., Widdig, A. (2023). Ten years of positive impact of a conservation education program on children's knowledge and behaviour towards crested macaques (Macaca nigra) in the Greater Tangkoko Area, North Sulawesi, Indonesia. International Journal of Primatology.</p
Literature and the Nugget of Knowledge. An Interview with Derek Attridge and Peter Lamarque
Get PDFThe idea of an interview with Peter Lamarque and Derek Attridge on the cognitive value of literary fiction arose in the wake of an aesthetics course on the relation between literature and truth at the University of Antwerp. In Spring 2015 Peter Lamarque contributed to this course with the lecture “The Opacity of Narrative and Fine-grained Reading”. In Spring 2017 Derek Attridge elaborated his view on the relation between literature and truth in his lecture “The Event of Truth : Literature’s Singular Relation to Knowledge”. After each lecture, we had the occasion to discuss with the author the stakes of the debate and we were rapidly convinced by the many points of convergences between their views. We intended to explore these similarities and differences through a face to face interaction and were happy that both philosophers accepted our invitation for an interview. This interview was conducted by Arthur Cools and Leen Verheyen in York on 9 July 2018
Literature and the nugget of knowledge : an interview with Derek Attridge and Peter Lamarque
No full textAbstract: The idea of an interview with Peter Lamarque and Derek Attridge on the cognitive value of literary fiction arose in the wake of an aesthetics course on the relation between literature and truth at the University of Antwerp. In Spring 2015 Peter Lamarque contributed to this course with the lecture \u201cThe Opacity of Narrative and Fine-grained Reading\u201d. In Spring 2017 Derek Attridge elaborated his view on the relation between literature and truth in his lecture \u201cThe Event of Truth : Literature\u2019s Singular Relation to Knowledge\u201d. After each lecture, we had the occasion to discuss with the author the stakes of the debate and we were rapidly convinced by the many points of convergences between their views. We intended to explore these similarities and differences through a face to face interaction and were happy that both philosophers accepted our invitation for an interview. This interview was conducted by Arthur Cools and Leen Verheyen in York on 9 July 2018
Ercilia, the Greek name of the poetess Antonia Díaz in the verses of Lamarque de Novoa
No full textJesús Troncoso, autor del presente artículo, descubre que la poetisa Antonia Díaz, la juvenil amiga y posterior amantísima esposa del poeta Lamarque de Novoa aparece en sus versos arropada bajo el seudónimo griego de Ercilia en varios poemas recogidos a m0do de antología en sus Poesías Líricas de 1895. En ellos se observa la evolución de un excelso amor idealizado que asciende desde la amistad hasta su dolorosa muerte en un romántico escenario modernista: el palacete de la Alquería del Pilar, construido para el disfrute de su amada en Dos Hermanas.The author of this article discovers that the poet Antonia Díaz, the youthful friend and later most loving wife of the poet Lamarque de Novoa appears in his verses under the Greek pseudonym of Ercilia in several poems collected as an anthology in his Poesías Líricas (Lyrical Poems) of 1895. In them we can observe the evolution of a sublime idealized love that ascends from friendship to her painful death in a romantic modernist setting: the palace of the Alquería del Pilar, built for the enjoyment of her beloved in Dos Hermanas
The making of a waterfront suburb: an ethnography of coastal gentrification in New Jersey
No full textThis dissertation is an ethnographic account of place-making in contemporary America. Here I examine and explicate the process of coastal gentrification underway in a New Jersey community and the form that is emerging from it, what I [call] a waterfront suburb. The construction of this kind of place combines elements of gentrification and suburbanization. I examine the place-making of Highlands, New Jersey, through the narratives that people created around their own experiences and how they imagined others, and through the values and social relations that emerged from and also shaped the borough's physical environment, economics, and histories. Class was a critical indicator of how informants related to the process, as was informants' tenure and geographic location in the borough. Also contributing to the construction of place were the event of a sewage spill that closed nearby commercial clam beds, the borough's recently revised Master Plan, and the everyday events that contributed to a process of coastal gentrification such as experiences with New York City commuter ferry traffic, local businesses and neighborly interactions.
In this research, I further suburbanization and gentrification studies by examining in one geographic locale the overlap and contrasts between those two processes. This advances a recent call to critique the dichotomization of city and suburb. I suggest that the construction of Highlands as a place of leisure and good views, a vacation spot for year-round living by the privileged classes, is a distinguishing feature of the waterfront suburb. While this aspect of the process underway in Highlands could also occur in any number of places inland, the process of coastal gentrification is further distinguished by the marine locale at which it occurs. This is because property rights regarding common pool resources may be more salient here than in inland areas. By examining how participants in the place-making of Highlands engage the coastal and marine environments in their actions and their rhetoric, this work expands the relatively young body of literature on coastal gentrification and proposes a new analytical lens, the waterfront suburb, through which to view the process.Ph. D.Includes bibliographical references (p. 330-347)
Deregulation of the AR non genomic signaling pathways in an in vitro SBMA model
No full textL'atrophie musculaire bulbo-spinale (SBMA) est une dégénérescence lente et progressive des motoneurones causée par l'élongation du triplet nucléotidique (CAG) dans le gène codant pour le récepteur aux androgènes (RA) localisé sur le chromosome X. Dans la SBMA, ce récepteur à extension polyglutaminique (polyQ) pathogène s'accumule de manière ligand dépendante dans le cytoplasme sous forme d'agrégats mais également dans le noyau y créant des corps d'inclusions nucléaires considérés comme la marque identitaire histologique, dont le caractère cytotoxique est aujourd'hui remis en question. Nous avons développé un modèle SBMA in vitro basé sur l'expression inductible d'un RA51Q dans la lignée hybride NSC34, qui est comparé au modèle normal NSC34 exprimant un RA contenant 20Q. Nous avons démontré que l'expression du RA51Q entraîne une diminution de la viabilité ainsi qu'une altération de la croissance neuritique sans formation d'agrégats insolubles dans le noyau ou le cytoplasme des cellules. Le RA en tant que membre de la superfamille des récepteurs nucléaires est un facteur de transcription mais peut également induire des voies de signalisation non génomiques via sa localisation membranaire. Après avoir montré une localisation du RA20Q et du RA51Q dans les « lipid rafts », nous avons corrélé la diminution de la viabilité et de la pousse neuritique induite par le RA51Q à une altération de la signalisation cellulaire non génomique. Les résultats obtenus mettent en évidence une dérégulation des voies de signalisation PI3K/Akt et JNK/c-jun induite par l'expression du RA muté dans notre modèle SBMA.Spinal Bulbar Muscular Atrophy (SBMA) is a progressive inherited motoneuron disease caused by the expansion of a trinucleotide (CAG) repeat in the gene coding for the androgen receptor (AR) located on the X chromosome. This rare disease causes muscle weaknesses, hypotonia, hyporeflexia, fasciculations of facial muscles in male patients. The androgen-dependent formation of cytoplasmic aggregates and nuclear inclusions are pathological hallmarks of this polyglutamine disease but their potential neurotoxicity is still under debate. We developed a SBMA model based on a doxycycline-inducible AR51Q expression system in the NSC34 hybrid cell line. We have shown that the expression of the mutated AR leads to a reduced viability and to an alteration of neurite outgrowth compared to cells expressing the normal AR20Q. The AR belongs to the nuclear receptor superfamily of transcription factors. However, recent data have put in evidence a membrane localization of AR initiating non-genomic signaling pathways. Because we have not observed insoluble aggregates, reduced viability and neurite outgrowth could not be correlated to AR aggregation. We hypothesized that motoneuron death is not only due to aggregate formation but also to the alteration of AR signaling pathways. We focused on a correlation between the AR localization in lipid rafts and the observed phenotypes. Our results highlight the deregulation of PI3K/Akt and JNK/c-jun signaling pathways induced by the expression of AR51Q in our SBMA model
Dérégulation de la signalisation non génomique du récepteur aux androgènes dans un modèle SBMA in vitro
No full textL'atrophie musculaire bulbo-spinale (SBMA) est une dégénérescence lente et progressive des motoneurones causée par l'élongation du triplet nucléotidique (CAG) dans le gène codant pour le récepteur aux androgènes (RA) localisé sur le chromosome X. Dans la SBMA, ce récepteur à extension polyglutaminique (polyQ) pathogène s'accumule de manière ligand dépendante dans le cytoplasme sous forme d'agrégats mais également dans le noyau y créant des corps d'inclusions nucléaires considérés comme la marque identitaire histologique, dont le caractère cytotoxique est aujourd'hui remis en question. Nous avons développé un modèle SBMA in vitro basé sur l'expression inductible d'un RA51Q dans la lignée hybride NSC34, qui est comparé au modèle normal NSC34 exprimant un RA contenant 20Q. Nous avons démontré que l'expression du RA51Q entraîne une diminution de la viabilité ainsi qu'une altération de la croissance neuritique sans formation d'agrégats insolubles dans le noyau ou le cytoplasme des cellules. Le RA en tant que membre de la superfamille des récepteurs nucléaires est un facteur de transcription mais peut également induire des voies de signalisation non génomiques via sa localisation membranaire. Après avoir montré une localisation du RA20Q et du RA51Q dans les lipid rafts , nous avons corrélé la diminution de la viabilité et de la pousse neuritique induite par le RA51Q à une altération de la signalisation cellulaire non génomique. Les résultats obtenus mettent en évidence une dérégulation des voies de signalisation PI3K/Akt et JNK/c-jun induite par l'expression du RA muté dans notre modèle SBMA.Spinal Bulbar Muscular Atrophy (SBMA) is a progressive inherited motoneuron disease caused by the expansion of a trinucleotide (CAG) repeat in the gene coding for the androgen receptor (AR) located on the X chromosome. This rare disease causes muscle weaknesses, hypotonia, hyporeflexia, fasciculations of facial muscles in male patients. The androgen-dependent formation of cytoplasmic aggregates and nuclear inclusions are pathological hallmarks of this polyglutamine disease but their potential neurotoxicity is still under debate. We developed a SBMA model based on a doxycycline-inducible AR51Q expression system in the NSC34 hybrid cell line. We have shown that the expression of the mutated AR leads to a reduced viability and to an alteration of neurite outgrowth compared to cells expressing the normal AR20Q. The AR belongs to the nuclear receptor superfamily of transcription factors. However, recent data have put in evidence a membrane localization of AR initiating non-genomic signaling pathways. Because we have not observed insoluble aggregates, reduced viability and neurite outgrowth could not be correlated to AR aggregation. We hypothesized that motoneuron death is not only due to aggregate formation but also to the alteration of AR signaling pathways. We focused on a correlation between the AR localization in lipid rafts and the observed phenotypes. Our results highlight the deregulation of PI3K/Akt and JNK/c-jun signaling pathways induced by the expression of AR51Q in our SBMA model.MONTPELLIER-BU Sciences (341722106) / SudocSudocFranceF
L'évolution des universités françaises au regard des paradigmes de l'action publique : quelle(s) alternative(s) au NPM ?
No full textInternational audienceLe paysage universitaire est en pleine transformation. Les différentes réformes à l’œuvre bouleversent l’organisation des établissements et favorisent la transformation des pratiques d’enseignement et de gestion des activités. L’Université française fait face à un risque accru d’inégalités au sein même des universités (taux de sélectivité, conditions de travail, budget alloué à la recherche), de perte d’identité (dispersion des moyens et des aides) et de concurrence accrue sur le plan international. Cet ouvrage collectif se propose d’aborder ce changement de contexte et ses conséquences pour l’Université et son mode de gouvernance, dans une perspective à la fois historique et prospective, en esquissant des tendances et différentes pistes d’action. Il vise par conséquent à enrichir le débat public sur un sujet essentiel pour l’avenir du pays tant en termes de formation, de recherche que de perspectives d’emplois. Ouvrage collectif dirigé par Jean-Philippe Denis (Univ. Paris-Saclay), Aude Deville (IAE Nice) et Olivier Meier (Univ. Paris-Est). Préface de Alain Cotta, avec les contributions de : Charlène Arnaud, Marc Bidan, Pierre Buffaz, Laurent Cappelletti, Nathalie Carminatti, Véronique Chanut, Thierry Côme, Jean-Philippe Denis, Aude Deville, Mbaye Fall Diallo, Fatou Diop, Sébastien Dony, Nathalie Fabbe-Costes, Julien Fernando, Mathilde Gollety, Léonard Gourbier, François Grima, Éric Lamarque, Corentin Mariette, Olivier Meier, Jérôme Méric, Emmanuelle Nègre, Gwenaëlle Nogatchewsky, Mickael Peiro, Gilles Rouet, Lolita Rubens, Claire Salmon, Alain Supiot, Marie-Anne Verdier
The Theory of Novelistic Truth
No full textAbstract
Since the very beginning of the novel, novelists have been concerned that their stories should be read with the same seriousness as history because their novels were as instructive as history. The view that the novel is true, true in its particulars, is not exclusive to authors. Readers have always had a tendency to identify events, situations, characters, and relationships from novels with events, situations, characters, and relationships in reality which the author can be taken as describing. This chapter considers the view that the novel is true in its particulars, true of certain types of situation, person, etc. in the real world, and that this is what gives it a humanly interesting content.</jats:p
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