5 research outputs found
Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries
No full text© 2015 Knowles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.NHM Repositor
Significant Early Loss of Correction in Modified Lapidus Compared to Original Lapidus for Hallux Valgus
No full textCategory: Bunion; Other Introduction/Purpose: The Lapidus procedure (first tarsometatarsal joint (TMT1) fusion) is an established treatment for correcting hallux valgus with 1st ray hypermobility. The original Lapidus (OL) technique involves fusing the TMT1 joint and first metatarsal base to the second, while the modified Lapidus (ML) technique involves fusing only the TMT1 joint. The purpose of this study was to investigate whether the ML procedure results in an early loss of correction. Methods: This retrospective study analyzed the outcomes of 45 feet in 40 patients with hallux valgus who underwent either the ML (21 feet) or OL (24 feet) procedure between 2014 and 2022 at a single center. All fixations were performed with 3.5 cortical screws, except for 9 cases that were fixed with a plantar locking plate. Differences in the immediate postoperative (6 weeks) and postoperative (6 months) intermetatarsal angle (IMA) and hallux valgus angle (HVA) were analyzed using Mann-Whitney tests, and complications were reported. Results: The mean preoperative IMA and HVA for the OL were 15.8° ± 3.5° and 36.4° ± 9.5°, respectively, and 14.5° ± 2.3° and 33.0° ± 7.0° for the ML. The immediate postoperative IMA and HVA were similar for both procedures (7.2° ± 2.0° and 7.7° ± 4.3° for OL, 7.3° ± 2.1° and 8.5° ± 5.5° for ML). Although from 6 weeks to 6 months postoperatively, the loss of correction of the HVA did not differ between both procedures (4.2° for OL, 5,6° for ML), the IMA loss of correction was significantly higher in the ML (1.1° ± 1.4° vs 0.5° ± 1.1°) (p < 0.05). One case of delayed union was reported in the OL group, but it did not require revision. Conclusion: The study results suggest that the ML procedure does not provide the same stability as the OL procedure in the early postoperative period, as there was a significantly greater early loss of correction of the IMA at 6 months postoperatively in the ML group compared to the OL group. Although there were no differences in the loss of correction of the HVA angle (HVA), an observed loss of 5 degrees remains a concern. Further studies are necessary to better understand the indications of the modified and original procedures
Early Radiological Outcome of Minimally Invasive Bunion Correction Using a Guided Trajectory System
No full textCategory: Bunion; Other Introduction/Purpose: Hallux Valgus correction with Minimally Invasive Surgery (MIS) is a popular procedure due to its potential advantages such as shorter operative time and quicker recovery than open surgery. Third-generation Minimally Invasive Chevron Akin (MICA) osteotomy has shown excellent clinical and radiological outcomes. The optimal fixation criteria are 3-point fixation (medial cortex, lateral cortex, and the lateral half of the 1st metatarsal head) for the proximal screws and 2-point fixation (medial cortex and central position in the 1st metatarsal head) for the distal one. To address the steep learning curve of the free hand technique, we describe a new guided trajectory system for third-generation MICA to increase precision and reduce the risk of suboptimal K-wire or screw placement. Early radiological outcomes and complications were reported. Methods: From April 2022 to January 2023, 13 consecutive MICAs were performed on 11 female patients (bilateral in 2 patients) with an average age of 61 by a single fellowship-trained foot and ankle orthopaedic surgeon who developed the device. These were the 13 first cases performed with the new device. Preoperative and postoperative intermetatarsal angle (IMA), hallux valgus angle (HVA), distal metatarsal articular angle (DMAA) and tibial sesamoid position (TSP) were measured in all patients using weight-bearing radiographs. Also evaluated in the postoperative radiographs were the number of cortical purchase of the screws and their position in the metatarsal head. Additionally, any difficulties or intraoperative complications and operative time were reported. All parameters were analysed with the one-tailed non-parametric Wilcoxon test. Results: All the radiographic parameters improved significantly. The median IMA improved from 14.5 degrees (interquartile range [IQR]: 11.5-16) to 5 degrees (IQR: 4.0-6.0) (p < 0.005). The median HVA also decreased from 27.5 degrees (IQR: 25.3-34.5) to 7.0 degrees (IQR: 4.0-8.5) (p < 0.005). The median DMAA fell from 15.5 degrees (IQR: 13.3-19.3) to 6.0 degrees (IQR: 6.0-8.0) (p < 0.005). The median TSP was 2 (IQR: 2-3) pre-operatively and 0 (IQR : 0-1) (p < 0.005) post-operatively. All the proximal screws for Chevron osteotomy had 3-point fixation and the distal anti-rotation screws had 2-point fixation No intraoperative complications were reported. The mean operative time was 52 (SD:10,4) minutes. Conclusion: Our study demonstrates the successful use of a guided trajectory system for minimally invasive bunion correction with optimal screw placement, good early radiological outcomes, and without extensive operating time. The absence of intraoperative complications or difficulties further confirms the efficacy of this system. Our findings suggest that the use of a guided trajectory system can potentially improve the consistency and success of third-generation MICA procedures. These results emphasize the benefits of incorporating guided trajectory systems in bunion correction surgeries and their potential to improve patient outcomes
Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease
No full textThe study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa
Impact of Implant Design and Coronal Deformity on Revision and Reoperation Rates in Total Ankle Arthroplasty: A Comparative Study
No full textCategory: Ankle Arthritis; Ankle Introduction/Purpose: Literature trends indicate a generally lower rate of reoperation and revision associated with the fixed-bearing two-component design implant compared to the mobile-bearing three-component design for total ankle arthroplasty (TAA). Coronal deformity is also linked to poorer outcomes following TAA. The aim of this study was to assess the impact of intra-articular coronal deformity (non-concentric ankle arthritis) on both fixed and mobile implant designs. We hypothesized that non-concentric ankle arthritis and mobile bearings would be associated with a higher early revision rate. Methods: This IRB approved retrospectivelreviewed 202 patients who underwent TAA with either mobile-bearing or fixed-bearing implants between 2007 and 2018. Patients who underwent TAA from 2007 to 2013 received the mobile-bearing implant, while those who underwent TAA after November 2012 received the fixed-bearing implant. Age, gender, ASA score, smoking status, BMI and eciology of the arthritis were reported from patients' record. Preoperative weight bearing x-ray were assessed for COFAS classification and intra-articular deformity. Non-concentric ankles were defined by a talar tilt angle greater than 4 degrees. The primary outcome was the rate of revision and reoperation within three years following the index procedure. Revision was defined as implants removal or exchange. Reoperation was defined as any additional surgery post-index surgery. The data underwent normality testing with the Shapiro-Wilk test, and comparisons were made via Kruskal-Wallis test and Chi square test. A p-value threshold of 0.05 or below was deemed significant. Results: All groups were not statistically different for age, gender, ASA score, BMI, and smoking status. Of the 76 patients who received a mobile-bearing implant, 33 had non-concentric arthritis, and 43 had concentric arthritis. Of the 126 patients who received a fixed-bearing implant, 61 had non-concentric arthritis, and 65 had concentric arthritis. In the mobile-bearing group, 8 patients underwent revision and 9 underwent reoperation. In the fixed-bearing group, 4 patients underwent revision and 10 underwent reoperation. In the non-concentric group revision rate was significantly higher (p< 0.05) for the mobile-bearing implant (15.2%) compared to the fixed-bearing implant (0%) . In the concentric group, no significant difference in revision rates between the fixed-bearing (6.2%) and mobile-bearing designs (7%) was observed. Reoperation rates were similar across all groups. Conclusion: The study suggested that the use of mobile-bearing implants in patients with non-concentric arthritis is associated with a significantly higher revision rate compared to fixed-bearing implants. In patients with concentric arthritis, there was no significant difference in revision rates between the two implant designs. Additionally, the study found no significant difference in the reoperation rates across all groups. Preoperative intra-articular deformity seems to be a predictor of early revision rate after total ankle arthroplasty
