1,354,911 research outputs found
1925-1926 Packard sedan, owner Otto Mathie at driver's door
No full text8x10 black and white Packard Co. file photograph of a 1925-1926 Packard left side view, parked on street in front of house, female driver and front passenger, owner Otto Mathie at driver's door. Inscribed on photo back: 326, third series six, 6-cylinder, 60-horsepower, 126-inch wheelbase, 5-person sedan (body type #221), 11/15/1929 Otto Mathie Milwaukee, Wisconsin, Model 3-26 sedan, motor #67726, delivered 9/30/1925, mileage 64,300, motor overhauled at 56,200 miles
Epistole Familiares
No full textcum Ascensianis introductiunculis recognitis & auctis, & argumentis illustratis, additis, regulis venusti sermonis ad finem operisKolophon: "Argentorati. In Aedibus Mathie Schurerii, Mense Martio M. D. XII. Tempus observa."Bogensignaturen: A⁴ B⁸-R⁴ S⁸, T⁴, Aa⁴ Bb⁸-Pp⁴ Qq⁸, Ss⁶, Tt
The Role of TASK-3 Two-Pore Domain Potassium Channels in the Entrainment of Mammalian Circadian Rhythms
No full textIn mammals light is the principal timing cue for alignment of physiology to the external environment. Illumination from the unrelenting 24-hour day-night cycle enters the biological system and is communicated to the master pacemaker, the suprachiasmatic nucleus (SCN) to drive circadian entrainment.
The decoding of light by the retina and the signalling pathways to and from the SCN rely on neural excitation mechanisms, achieved through changes in membrane potential from a resting state stabilised by K2P channels. With TASK-3 being the most abundant K2P channel in the rodent SCN it is feasible this channel has a crucial role in regulating SCN neural transmission for effective circadian entrainment. This study investigates this role through the use of transgenic TASK-3 KO mice.
In the first experimental chapter I demonstrate the presence of TASK-3 mRNA in the SCN and retina of wild type mice. Further, I reveal a circadian pattern in TASK-3 mRNA expression with significant midday nadir which feasibly influences resting membrane potential (RMP) supporting increased neuronal excitation reported at this time.
The following three chapters explore TASK-3 conductance in behavioural output rhythms via locomotor activity studies under light-dark cycles and in constant darkness. This series of experiments highlights how TASK-3 is essential for effective adjustment to changing light and how loss of this channel reduces light-driven and endogenous activity intensity and rhythm amplitude.
With light entering the circadian system exclusively via the eyes, the role of TASK-3 at the level of the retina is of upmost importance to entrainment. This is investigated in chapter 6 using pupillary light reflex as a measure of retinal sensitivity and decoding capacity. Through manipulation of intensity and wavelength specific classes of photoreceptor are studied for their contribution to this non-image forming response. These experiments show TASK-3 ablation significantly attenuates retinal sensitivity to sub-saturating light in a mechanism likely to be melanopsin-independent.
Finally examination of mRNA expression of core clock genes reveals the role of TASK-3 at the level of the SCN. Here, loss of TASK-3 conductance is shown to alter daily rhythms in several key genes thereby linking the properties of this background leakage channel to the molecular clockwork.
Overall these experiments demonstrate some of the roles TASK-3 conductance plays within the SCN and in output rhythms; and the requirement of this channel within the retina for effective retinal decoding across the visible spectrum over a range of light intensities
Guide to Receptors and Channels, 2nd edition (2007 Revision)
No full textThe article focuses on the publication of the "Guide to Receptors and Channels," 2nd edition, by S. P. H. Alexander, A. Mathie and J. A. Peters, which offers a rapid overview of the key properties of a wide range of established or potential pharmacological targets. The guide offers information on targets of similar structure and function including transmitter-gated channels, ion channels, nuclear receptors and enzymes
Apprenticeship Pathways: Comparative Lessons in developing Apprenticeships that Work
No full textThese slides are from a presentation given by Andrea Messing-Mathie at the Symposium on the Supply Chain for Middle-Skill Jobs: Education, Training, and Certification Pathways. This presentation discusses apprenticeship systems. The main slide topics of the presentation include Interest in cross-national learning, "Learn and Earn," Dual-Study Model, A Framework for Developing Apprenticeship Systems, and more. These presentation slides are available free for download.&nbsp
La Pucelle D'Orleans
No full textEnthält eine Widmung an: "A ... Madame La Mareschalle de la Chastre."Die Rückseite des Titelblatts ist unbedrucktEnthält Beiträge von: "... Brisant le Sort.", "... Barentin.", "... Guy de Tours." sowie "... Mahoudeau.", "... De Nancel.", "... Fauuelaye.", "... Pauneau." und "... De Vabres."Vorlageform der Veröffentlichungsangabe: A Paris, Chez Mathie Guillemot, au Palais, en la gallerie par ou on va à la Chancellerie. 1599. - Titelkupfer: A Paris Chez Mathieu Guillemot au pallais en la gallerie des prisonniers. ... 159
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Building Apprenticeship Systems for Middle-Skill Employment: Comparative Lessons in Innovation and Sector-Based Strategies for Apprenticeships
No full textThis 34-page paper, written by Andrea Messing-Mathie, discusses apprenticeship systems for middle-skill workers. The following topics are discussed: youth unemployment and the challenge of skills shortage, existing apprenticeship systems and different innovative approaches, and the potential for expanding apprenticeship as a part of career pathways systems.The following sections are included in this paper: Introduction, Skills Mismatch: Youth Unemployment and Unfilled Positions; Lessons from Mature Apprenticeship Systems; Legislation is coherent and aims for a simple but effective framework; A strong intermediary is key to a strong apprenticeship program; There is an equitable sharing of costs among employers, the public, and apprentices; and more.&nbsp
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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