67 research outputs found
Handsome revenge
No full textHandsome Revenge is a Graphic Novel staring a vigilante Pulp-Hero in the tradition of The Shadow; The Spider; Diabolik; The Bat-Man, and The Spirit. Following the clues of the dead and dying members of a former crime organization named the “Golden Age,” The Gray Gambler finds himself hunted and taunted by the eponymous “Handsome Man.” However, The House of Justice always deals a winning hand against the forces of crime; crookdom; shysters; and those evanescent creatures that exist to wreak havoc upon the dreadful waste of a city named Hunger—but for The Gray Gambler, it is City, and he must risk life, limb, and all his agents to stop this ‘Man’ from causing more death and destruction!M.F.A.by Dean Patrick Stecke
Portrait of banker and author Jackson Alpheus Graves, ca.1910-1920
No full textPhotographic portrait of banker and author Jackson Alpheus Graves (Jackson C.? Graves), ca.1910-1920. Viewed from the chest up. He is wearing a long polka-dot tie with tie-pin, light-colored shirt, and pin-stripe jacket. He has short white hair with a receding hairline. He has a short mustache. He is turned slightly to his left. He lived from 1852 to 1933.; Graves authored the book "My seventy years in California, 1857-1927"
Interpartikuläre Wechselwirkungen zwischen maßgeschneiderten Mannitolträgerpartikeln und Arzneistoffpartikeln für Inhalationszwecke
No full textDrug delivery to the lungs is known as the main application route to treat diseases like asthma or chronic obstructive pulmonary disease. Particles for lung penetration require aerodynamic particle sizes between 0.5 µm and 5.0 µm to provoke an effect. Dry powder formulations as used in this project provide improved long term stability when compared to liquid formulations. The well-established system of coarse carrier and small cohesive drug particles was applied in this work to overcome drug cohesiveness and facilitate dosing accuracy.
This project was mainly focussing on the preparation of mannitol carrier and drug particles with controlled particle properties to discover the effects of those properties on particle-particle interactions and so on the resulting fine particle fraction – as the fraction of particles with an aerodynamic diameter below 5 µm gained by impaction analysis.
Spray drying was used as method of choice for all substances used. A design of experiments was applied for the drying of mannitol. Drying experiments resulted in different qualities based on different rotation speeds of a rotary atomiser and different drying temperatures, resulting in particles of different sizes and morphologies. With this it was possible to illustrate the drying kinetics with respect to the temperature within droplet or early particle.
Four hydrophilic and hydrophobic model drugs were spray dried with a commercially available spray drier. Resulting batches were blended with a choice of six mannitol batches.
Aerodynamic characterisations exhibited carrier shape to have the main impact on drug dispersion, but illustrated different drugs to show different dependencies with respect to drug-to-drug and drug-to-carrier interactions. Apart from carrier shape, carrier and drug size were found to be important for accurate drug dispersion.
This project gives a broad overview over particle-particle interactions between carrier and drug particles of various qualities during inhalation.Die pulmonale Gabe von Arzneistoffen zur Behandlung von Asthma und der chronisch obstruktiven Lungenerkrankung wird standardmäßig angewandt. Eine aerodynamische Partikelgröße zwischen 0,5 und 5 µm ist erforderlich, um einen Effekt zu erzielen. Trockenpulverformulierungen bieten hierbei Vorteile hinsichtlich der Lagerstabilität verglichen mit flüssigen Formulierungen. Ein System aus grobem Träger und feinem kohäsivem Arzneistoff wurde hierbei angewandt, um die Kohäsivität zu umgehen und akkurates Dosieren zu ermöglichen.
Dieses Projekt zielte auf die Herstellung von Mannitolträger- und Arzneistoffpartikeln mit kontrollierten Eigenschaften, um deren Effekte auf die interpartikulären Wechselwirkungen und damit im Rahmen einer Impaktionsanalyse auf die Feinpartikelfraktion als Fraktion der Partikel mit einem aerodynamischen Durchmesser < 5 µm zu untersuchen.
Sämtliche Substanzen wurden mittels Sprühtrocknung hergestellt. Mannitol wurde einem Versuchsplan folgend hergestellt. Die Produkte unterschieden sich vor allem hinsichtlich Partikelgröße und –form, was sich über die Rotationsgeschwindigkeiten des Rotationszerstäubers oder über die variierten Trocknungstemperaturen erklären ließ. Zusätzlich wurde hierbei die Trocknungskinetik hinsichtlich der inneren Tropfentemperatur untersucht.
Zudem wurden vier hydrophile und hydrophobe Arzneistoffe mit einem kommerziellen Sprühtrockner getrocknet und mit einer Auswahl von sechs Mannitolträgerchargen zu interaktiven Mischungen vermischt.
Die aerodynamische Charakterisierung zeigte, dass vor allem die Trägerpartikelform Einfluss auf die Dispergierung nimmt, wobei unterschiedliche Arzneistoffe basierend unterschiedlichen Wechselwirkungen andere Abhängigkeiten aufwiesen. Zusätzlich zeigten sich Träger- und Arzneistoffpartikelgröße als einflussnehmend auf die Dispergierung.
Dieses Projekt ermöglicht eine breite Übersicht hinsichtlich der interpartikulären Wechselwirkungen zwischen Träger und Arzneistoffpartikeln während der Inhalation
Tree species growth response to climate in mixtures of Quercus robur/Quercus petraea and Pinus sylvestris across Europe - a dynamic, sensitive equilibrium
No full textFluffy Publication Workflow: Preserving Humanities Research Data with the TextGrid Repository
No full textImplications of Reduced Stand Density on Tree Growth and Drought Susceptibility: A Study of Three Species under Varying Climate
No full textA higher frequency of increasingly severe droughts highlights the need for short-term measures to adapt existing forests to climate change. The maintenance of reduced stand densities has been proposed as a promising silvicultural tool for mitigating drought stress. However, the relationship between stand density and tree drought susceptibility remains poorly understood, especially across ecological gradients. Here, we analysed the effect of reduced stand density on tree growth and growth sensitivity, as well as on short-term drought responses (resistance, recovery, and resilience) of Scots pine (Pinus sylvestris L.), sessile oak (Quercus petraea (Matt.) Liebl.), and ponderosa pine (Pinus ponderosa Douglas ex C. Lawson). Tree ring series from 409 trees, growing in stands of varying stand density, were analysed at sites with different water availability. For all species, mean tree growth was significantly higher under low compared with maximum stand density. Mean tree growth sensitivity of Scots pine was significantly higher under low compared with moderate and maximum stand density, while growth sensitivity of ponderosa pine peaked under maximum stand density. Recovery and resilience of Scots pine, as well as recovery of sessile oak and ponderosa pine, decreased with increasing stand density. In contrast, resistance and resilience of ponderosa pine significantly increased with increasing stand density. Higher site water availability was associated with significantly reduced drought response indices of Scots pine and sessile oak in general, except for resistance of oak. In ponderosa pine, higher site water availability significantly lessened recovery. Higher site water availability significantly moderated the positive effect of reduced stand density on drought responses. Stand age had a significantly positive effect on the resistance of Scots pine and a negative effect on recovery of sessile oak. We discuss potential causes for the observed response patterns, derive implications for adaptive forest management, and make recommendations for further research in this field
Literary coaches as staff developers in urban elementary schools
No full textThesis (Ed. D.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.The focus of this study was to create a living portrait of the work life ofliteracy
coaches, a new and evolving occupation for staff developers. Coaches with expertise in
literacy curriculum, instruction, and assessment have been hired to work with teachers
and administrators in urban elementary schools and help them to improve instruction for
urban youth.
Coaches, teachers, and principals in four northeastern cities participated in this
study. Coaches were observed, interviews were conducted, and participants were asked
to provide samples of student work, schedules, or other documents that were used to
triangulate data obtained from observation and interviews.
Of the five coaches in the study (three part-time, external coaches and two fulltime,
internal coaches), reports indicate that two of the part-time coaches were most
successful. Supervisory or administrative responsibilities, particularly identification and
remediation of problematic teachers, created an obstacle for both of the full-time coaches.
It created the perception among other members of the faculty that the coaches were
forcing a top-down agenda for change. The effectiveness of the principal as an
instructional leader, the coaches' ability to manage their daily work, the personality of
individual coaches, and process by which they choose to engage teachers also had an
effect on their ability to promote change.
The successful coaches appealed to the intrinsic motivation of teachers to improve
instruction by explicitly demonstrating how some practices are beneficial to students.
Having gained the initial commitment of teachers, the successful coaches focused on
helping teachers to internalize strategies that would allow them to become more reflective
about their practice and better able to adapt instruction to the diverse needs of their
students.
The successful coaches were working in districts with organized reform
initiatives, and were working in schools with principals who were knowledgeable about,
and dedicated to literacy reform. Their principals had created time for teacher
collaboration and professional development to be part of the teachers' workday.2999-01-0
Climate And Environmental Changes: Restrospect And Prospect
No full textDiscussion on problems of climate and environmental changes i.e. global warming has inundated in recent years. Every major newspaper publishes multiple editorials or op- ed pieces on the topic, the broadcast media and researchers regularly discuss the issue, and thousands of Web pages and blogs provide definitions and information and suggest causes and consequences of action and inaction. Under the situation why are we adding to congestion on the subject? Because the analysis of past has much to contribute, especially in understanding prospects of adapting to climate change, which has received relatively little study and comment relative to the standing it should take in the debate [Gary D. Libecap and Rechard H. Steckel, 2011]. At the outset, it is to be noted that in the present paper science of climate change is not evaluated as author is not the expertise to contribute on this matter but the paper respond to economic effects of the climate and environmental changes
Understanding the trends in income, consumption and wealth inequality and how important are life-cycle effects?
No full textRising inequality in income, wealth and consumption has received a good deal of public attention in the past years. At the same time, also macroeconomists are more and more interested in inequality as they have expanded their models to incorporate heterogeneity in the household sector. We supply these models with empirical benchmarks for their calibration and contribute to the understanding of the reasons underlying the trends in inequality. Specifically, we employ a variance decomposition and estimate life-cycle profiles of inequality in income, consumption and wealth based on two measures of inequality. We deepen the discussion on wealth inequality by evaluating the relative importance of savings, portfolio choice and inheritances for the accumulation of wealth. To do so, we project active and passive savings based on the observed saving and investment behavior of synthetic cohorts from the German Income and Expenditure Survey (EVS).
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