21 research outputs found
Beneficial effects of pregnancy in multiple sclerosis reflected by cytokine pattern and prolactin
No full textBeneficial effects of pregnancy in multiple sclerosis reflected by cytokine pattern and prolactin
No full textToxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1 alpha
No full textThe obligate intracellular protozoan parasite Toxoplasma gondii is able to establish persistent infections within human and animal hosts. We have shown recently that T. gondii downregulates IFN-gamma -induced MHC class II expression in murine bone marrow-derived macrophages (BMM phi). As shown in this study, the capacity of IFN-gamma -activated murine BMM phi to present ovalbumin to CD4(+) T cell hybridomas was dose-dependently inhibited by T. gondii. IFN-gamma -induced up-regulation of H2-Aa, H2-Ab, H2-Eb, H2-Ma, H2-Mb, H2-Oa and invariant chain transcripts was prominently down-regulated by T. gondii. Furthermore, mRNA levels of class II transactivator and interferon-regulatory factor-1 were significantly diminished. Electromobility shift assays demonstrated a decrease in the binding activity of nuclear extracts to the IFN-gamma -activated site after infection with T gondii, indicating parasitic interference with IFN-gamma -induced signaling. However, neither the expression of the IFN-gammaR nor the IFN-gamma -induced tyrosine phosphorylation of IFN-gammaR alpha chain and signal transducer and activator of transcription (STAT) 1 alpha was diminished by T. gondii. IFN-gamma -induced nuclear translocation of STAT1 alpha was nevertheless inhibited after infection as demonstrated by immunofluorescence microscopy and subcellular fractionation analyses. In conclusion, this novel mechanism of microbial interference with MHC class II gene expression may contribute to intracellular survival and establishment of persistent infection with T:gondii
Time-dependent alterations of inflammatory changes at the blood-brain barrier in AT-EAE: implications for future treatment studies
No full textTime-dependent alterations of inflammatory changes at the blood-brain barrier in AT-EAE: implications for future treatment studies
No full textMaeurer, Mathias (Death, 1907-12-11)
No full textAddress: 617 McMickenAge at death: 49 yrs.176/Pg.133/1907/M W M/Germany/Dr. E. Landy/Busse & Borgmann/Vine St. HillOriginal record filed in drawer labeled 'MACK, R-MAIN'
TRUST study design-a study to evaluate an integrated approach for optimized patient management in multiple sclerosis patients treated with natalizumab
No full textTRUST study design-a study to evaluate an integrated approach for optimized patient management in multiple sclerosis patients treated with natalizumab
No full textTribologische Untersuchungen an Radialgleitlagern aus Kunststoffen
No full textPlastic sliding bearings in massive and composite structure mostly are used as wearing bearing. The author tries to improve the availability of thermoplastic massive sliding bearings with radial realization under different operation conditions. Experiments with initial lubrication and start-stop operation are described. The wear behavior of thermoplastic massive sliding bearings is determined with run-up and run-out experiments. The experiments concerning to the sliding bearings are realized on special test stands. This considers the fact that proceedings in thermoplastic sliding bearings are a part of complex tribologic systems. Short-time experiments provide sufficiently exact statements according to specific wear rates. If the thermoplastic sliding bearing works at its maximum load, the chemical degradation of the plastics and a reduction of the durability of the storage material may be observed. An initial lubrication with fat decreases the medium-coefficient of friction, the specific shear rate and storage temperatures. Non lubricated HT thermoplastic sleeve bearings can be used successfully at start-stop operations. In comparison to endurance tests with non lubricated HT thermoplastic sleeve bearings, little medium coefficients of friction and little specific wear rates are established in start-stop operation. Endurance tests with non lubricated sheathed bearings provide little medium coefficients of friction in comparison to non lubricated sleeve bearings. The specific wear rate is higher as in the case of sleeve bearings. The basic estimations with respect to the endurance tests with non lubricated sleeve bearings are transferable to the start-stop experiments.114 figs., 37 tabs., 152 refs.Available from: http://archiv.tu-chemnitz.de/production-stable/pub/2003/0116/index.html / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Activation of disease during therapy with alemtuzumab in 3 patients with multiple sclerosis
No full textObjectiveTo report 3 patients with multiple sclerosis showing severe activation of disease during immunotherapy with alemtuzumab.MethodsRetrospective case series.ResultsPatient 1, a 21-year-old woman, developed severe cognitive impairment, sight deterioration, severe gait ataxia, urinary retention, and extensive progression of cerebral lesion load, including new lesions that exhibited gadolinium ring enhancement and dominance of CD19/20-positive B lymphocytes, 6 months after induction of alemtuzumab. Patient 2, a 28-year-old man, developed left-sided hemihypesthesia and ∼60 new cerebral and spinal lesions including lesions with gadolinium ring enhancement 6 months after induction of alemtuzumab. Patient 3, a 37-year-old woman, developed ataxia and numbness of the left thigh, 16 new gadolinium-positive supratentorial lesions, and partly ring-enhancing and dominance of CD19/20-positive B lymphocytes 6 months after induction of alemtuzumab.ConclusionThis is a case series reporting severe activation of disease during immunotherapy with alemtuzumab. All patients showed onset of symptoms 6 months after induction of alemtuzumab, strikingly similar MRI lesion morphology, and unexpected high total B cell count, which may suggest a B-cell-mediated activation of disease. Whether this is due to different rates of B- and T cell repopulation has to be the subject of further research. Moreover, further effects on the interactions between the adaptive and innate immunity as well as between B and T cell lineages might explain the observed disease activation.</jats:sec
