1,720,994 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial
No full texthttp://dx.doi.org/10.13039/501100003042 Else Kröner-Fresenius-Stiftunghttp://dx.doi.org/10.13039/501100014178 Riemser Pharma Gmb
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Malignant lymphomas - molecular mechanisms and therapeutic implications of deregulated signaling pathways
No full textSchwerpunkt der eigenen wissenschaftlichen Arbeiten ist die Erforschung der
Pathogenese reifzelliger lymphatischer Neoplasien. Es ist das Ziel dieser
Arbeiten, molekulare und/oder genomische Schlüsseldefekte zu identifizieren,
um zum einen die Pathogenese dieser Erkrankungen besser verstehen zu können
und zum anderen, basierend auf entsprechenden Defekten, zielgerichtete
Therapiestrategien zu entwickeln. Fokus der eigenen Arbeiten ist dabei
insbesondere die Analyse deregulierter Transkriptionsfaktoren und Signalwege
sowie deren Rolle für Wachstum, Schutz vor Zelltod sowie Störung zellulärer
Differenzierungsprogramme. Im Rahmen dieser Arbeiten konnten insbesondere
Schlüsselbefunde der Pathogenese des klassischen Hodgkin-Lymphoms (cHL), des
anaplastischen großzelligen Lymphoms (ALCL) sowie des Sézary-Syndroms, einer
Sonderform kutaner T-Zell-Lymphome, erhoben werden. Insbesondere wurde im cHL
und ALCL u.a. die pathogenetisch wichtige aberrante AP-1-Aktivität
beschrieben, und es wurden Mechanismen der Apoptoseresistenz oben genannter
Lymphomentitäten aufgearbeitet. Darüber hinaus konnten wir einen Mechanismus
der ungewöhnlichen Dedifferenzierung der Hodgkin-/Reed-Sternberg (HRS)-Zellen
beschreiben, der auf der funktionellen Blockade B-Linien-spezifischer
Transkriptionsfaktoren beruht. Basierend auf dieser Arbeit wurde ein Konzept
der Reprogrammierung der HRS-Zellen entwickelt, welches neben einer möglichen
prognostischen und therapeutischen Relevanz zur Identifizierung eines neuen
Mechanismus der Onkogenaktivierung über long-terminal-repeat-Elemente der DNA
führte. Wir konnten zudem aufzeigen, dass sich am cHL erhobene Befunde und
Konzepte auf andere Lymphomentitäten wie beispielsweise das primäre
Effusionslymphom übertragen lassen. Im Hinblick auf einen möglichen
translationalen Ansatz konnten, basierend auf den identifizierten molekularen
Defekten, bereits vielversprechende in vitro- und teilweise in vivo-
Untersuchungen u.a. mit Tyrosinkinase-Rezeptor-Inhibitoren, Arsenderivaten
oder CSF1R-blockierenden Substanzen durchgeführt werden. Letztendlich ist es
das Ziel der eigenen Arbeiten, einen Beitrag zur Entwicklung zielgerichteter
und wenig toxischer Therapiestrategien zur Behandlung maligner Lymphome zu
leisten.Main focus of the the own scientific work is the pathogenesis of mature
lymphoid neoplasias. It is the aim to identify molecular and/or genomic
defects to understand the underlying pathogenic mechanisms of these diseases
and to develop targeted treatment strategies. In particular, we focus on
deregulated transcription factors and signaling pathways. Key defects of
classical Hodgkin lymphoma (cHL), anaplastic large cell lymphoma (ALCL) and
Sézary syndrome have already been identified. We have discovered the aberrant
AP-1 activity and described mechanisms of apoptosis resistance of the above
mentioned lymphomas. Furthermore, the mechanisms of cellular dedifferentiation
of the malignant Hodgkin-/Reed-Sternberg cells of cHL have been identified.
Based on these results, a concept for HL-pathogenesis was developed which
ultimately resulted in the discovery of a new mechanism of oncogene activation
by DNA long-terminal-repeat element derepression. Regarding possible
therapeutic implications of this work, promising preclinical results could be
obtained by treatment of lymphoma cells with tyrosine-kinase inhibitors,
arsenic or CSF1R-inhibiting small compounds. It is the aim of the presented
work to develop targeted treatment strategies based on pathogenetically
relevant molecular defects
High-Dose Chemotherapy and Autologous Stem Cell Transplant in Elderly and Fit Primary CNS Lymphoma Patients - a Multicenter Study By the Cooperative PCNSL Study Group (MARTA study)
No full text- …
