1,721,025 research outputs found
Determination of purine and pyrimidine bases, nucleosides, and nucleotides 5'-monophosphate by hydrophilic liquid interaction chromatography (HILIC) and UV detection
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Anti- and prooxidant activity of water soluble components of some common diet vegetables and the effect of thermal treatment
No full textThe pro-antioxidant activity of carrot, cauliflower, celery, eggplant, garlic, mushroom, onio, white cabbage, white potato, tomato, yellow bell pepper, and zucchini, was investigated. Juices obtained by centrifugation of vegetables were treated at different temperatures (2, 25, 102°C) and assessed for antioxidant activity (AA) using a model system beta carotene-linoleic acid. Antioxidant activity of vegetable juices showed a linear correlation with time. The equations of all straight lines obtained showed positive slope values indicating either an increase in antioxidant activity or a decrease in prooxidant activity during the reaction. Negative intercept values were found when the juices showed prooxidant activity at least during the first phase of the reaction. Mushroom and white cabbage always showed more than 80a, while cauliflower, celery, and eggpland showed such high AA only after boiling. Tomato and yellow bell pepper were always prooxidant. Cluster analysis allowed the the vegetables to be divided into five groups according to their anti- and prooxidant behavior as a function of thermal treatment and reaction time. Vegetable juice components were separated on Bakerbond C18 solid phase extraction cartridge according to their polarity, and the AA of the bound and unbound fractions of each vegetable was also tested
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Functional materials with nano-micro sized internal structure for biomedical applications
Full text linkBio-guided fractionation of stem bark extracts from phyllanthus muellarianus: Identification of phytocomponents with anti-cholinesterase activity
Full text linkA combination of flash chromatography, solid phase extraction, high-performance liquid chromatography, and in vitro bioassays was used to isolate phytocomponents endowed with anticholinesterase activity in extract from Phyllanthus muellarianus. Phytocomponents responsible for the anti-cholinesterase activity of subfractions PMF1 and PMF4 were identified and re-assayed to confirm their activity. Magnoflorine was identified as an active phytocomponent from PMF1 while nitidine was isolated from PMF4. Magnoflorine was shown to be a selective inhibitor of human butyrylcholinesterase—hBChE (IC50 = 131 ± 9 μM and IC50 = 1120 ± 83 μM, for hBuChE and human acetylcholinesterase—hAChE, respectively), while nitidine showed comparable inhibitory potencies against both enzymes (IC50 = 6.68 ± 0.13 μM and IC50 = 5.31 ± 0.50 μM, for hBChE and hAChE, respectively). When compared with the commercial anti-Alzheimer drug galanthamine, nitidine was as potent as galanthamine against hAChE and one order of magnitude more potent against hBuChE. Furthermore, nitidine also showed significant, although weak, antiaggregating activity towards amyloid-β self-aggregation
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Analytical approaches for the identification of new ligands of Peroxisome Proliferator-Activated Receptors: a complex journey.
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