745 research outputs found
Fare scuola a classi aperte in rete. Sperimentazione di didattica condivisa in piccole scuole isolate e con pluriclassi
No full textENG:
In the school year 2020-2021, INDIRE launched in Italian small schools a pilot experimentation of a teaching meth- od already validated in Québec and considered useful for overcoming the educational limits typical of remoteness scenarios (Mangione and Cannella, 2020). “Classi in rete” is characterized by a shared didactic practice where “de-localized” classes are involved in a common disciplinary path by adapting calendars, spaces, and teacher roles, using virtual twinning environments, videoconferencing and spaces for discussion such as the Knowledge Forum (KF) (Mangione and Pieri 2019; Mangione et al., 2021). The experimentation of the model in Abruzzo involved 12 small schools and is based on a design-based research methodological approach (Sandoval, 2014). This paper aims to answer the following questions:
Q1 Has the experience of networked classes fostered changes in the teaching practices and strategies of teachers?
Q2 Which are the elements that conditioned the teamwork in open classes?
The analysis uses a mixed method that integrates a standard search through data matrix and an interpretative search through group interviews aimed at the involved teachers and students. In fact, alongside a structured quantitative survey aimed at understanding the impact that the model had in the experimental classes in terms of collaboration, interdisciplinarity, reorganization of times and workspaces, we conducted a qualitative analysis based on focus groups with the teachers involved aimed at understanding to what extent the model has affected their propensity for change.
ITA:
Nell’anno scolastico 2020-2021, INDIRE ha avviato una sperimentazione pilota nelle piccole scuole italiane di un metodo didattico già validato in Québec e ritenuto utile per superare i limiti educativi che si verificano in situazioni di remoteness (Mangione e Cannella, 2020). “Classi in rete” si caratterizza per una pratica didattica condivisa dove classi “delocalizzate” vengono coinvolte in un percorso disciplinare comune adattando calendari, spazi e ruoli dei docenti utilizzando ambienti di gemellaggio virtuale, di videoconferenza e spazi di argomentazione come il Knowledge Forum (KF) (Mangione e Pieri 2019; Mangione et al., 2021). La sperimentazione del modello in Abruzzo ha coinvolto 12 piccole scuole e poggia su un approccio metodologico di analisi di tipo design-based research (Sandoval, 2014) L’articolo vuole restituire una risposta alle seguenti domande:
D1 L’esperienza di classi in rete ha favorito cambiamenti nelle prassi e strategie didattiche dei docenti?
D2 Quali sono gli elementi che hanno condizionato il lavoro per gruppi a classi aperte?
L’analisi si avvale di un metodo misto che integra una ricerca standard tramite matrice dati e una ricerca di tipo interpretativo tramite interviste di gruppo rivolte ai docenti coinvolti e agli studenti. Infatti, accanto a un’indagine quantitativa strutturata volta a comprendere l’impatto che il modello ha avuto nelle classi sperimentali in termini di collaborazione, interdisciplinarità, riorganizzazione dei tempi e degli spazi di lavoro, è stata condotta un’analisi qualitativa basata su focus group con i docenti per rilevare quanto il modello abbia inciso sulla loro propensione al cambiamento
Alterazione funzionale dei canali ionici nel sistema nervoso centrale in un modello murino di sclerosi laterale amiotrofica
No full textAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a
substantial loss of motor neurons in the spinal cord, brainstem and motor cortex. The degeneration
of motor neurons leads to skeletal muscle atrophy, paralysis and death. The mechanisms by which
mutations in SOD1 lead to motor neuron degeneration remain unidentified. Several mechanisms
have been suggested by which a mutation of SOD1 may lead to motor neuron toxicity and
degeneration, including the formation of intracellular aggregates (Johnston et al., 2000), production
of reactive oxidative species (Estevez et al., 1999), mitochondrial degeneration (Higgins et al.,
2002), altered AMPA receptor permeability and subunit composition (Pieri et al., 2003; Spalloni et
al., 2004), increase in intracellular Ca2+ concentration by Ca2+-permeable AMPA receptor channels
(Van Den Bosch et al., 2000; Weiss et al., 2000) and protein nitration (Casoni et al., 2005). In the
present work, the excitability of motor neurons and the physiological properties of the macroscopic
voltage-dependent Na+, Ca++ and K+ currents have been tested in a transgenic mouse model of a
familial form of ALS, associated with a mutation in Cu,Zn superoxide dismutase (Gly93 Ala).
The results indicate that the passive membrane properties were not modified in G93A motor
neurons compared to control neurons whereas the firing properties of single motor neurons in G93A
are altered to induce in these neurons hyperexcitability.
In addition, the voltage dependence of activation and of steady-state inactivation, the kinetics of fast
inactivation and slow inactivation of the voltage-dependent Na+ channels were not modified in the
mutated mice. Conversely, the recovery from fast inactivation was significantly faster in G93A
motor neurons compared to control neurons. The recovery from fast inactivation was still
significantly faster in G93A motor neurons exposed for different times (3-48 hours) and
concentration (5-500 μM) to edaravone, a free radical scavenger.
The analysis of the voltage-dependent calcium currents and potassium currents showed not
significant differences in all the parameters studied in the three neuronal populations.
Finally, to investigate which modifications at the ionic current level can produce the observed
hyperexcitability in G93A motor neurons, we developed a numerical simulator of the electrical
activity of mouse spinal motor neuron. We found that changes limited to ionic current conductances
or to faster recovery from fast inactivation of the Na+ channels are not able to reproduce G93A
firing alterations. We observed that the mutant motor neuron hyperexcitability can be reproduced by
means of a faster kinetic of small conductance calcium-dependent potassium current.
These results indicate for the first time that, in accordance with clinical data, the firing properties of
single motor neurons in a genetic mouse model of ALS are altered to induce neuronal
hyperexcitability and that they may contribute to the pathogenesis of the disease. The clarification
of the importance of these changes in membrane ion channel functionality may have diagnostic and
therapeutic implications in the pathogenesis of ALS. This alteration, demonstrated at the single-cell
level, may affect the normal orchestrated activation and inactivation gating of the voltagedependent
channels involved in the neuronal excitability and may be significant in the onset and
progression of the pathology. For these reasons, an electrophysiological characterization of small
conductance calcium-activated potassium current will be necessary in order to experimentally
verify the simulation results
Affine Pieri rule for periodic Macdonald spherical functions and fusion rings
No full textLet gˆ be an untwisted affine Lie algebra or the twisted counterpart thereof (which excludes the affine Lie algebras of type BCˆn=A2n(2)). We present an affine Pieri rule for a basis of periodic Macdonald spherical functions associated with gˆ. In type Aˆn−1=An−1(1) the formula in question reproduces an affine Pieri rule for cylindric Hall-Littlewood polynomials due to Korff, which at t=0 specializes in turn to a well-known Pieri formula in the fusion ring of genus zero slˆ(n)c-Wess-Zumino-Witten conformal field theories.Applied Probabilit
Kraśkiewicz-Pragacz Modules and Pieri and Dual Pieri Rules for Schubert Polynomials
No full textIn their 1987 paper Kra\\u27skiewicz and Pragacz defined certain modules \smod_w (), which we call KP modules, over the upper triangular Lie algebra whose characters are Schubert polynomials. In a previous work the author showed that the tensor product of KP modules always has a KP filtration, i.e. a filtration whose each successive quotients are isomorphic to KP modules. In this paper we explicitly construct such filtrations for certain special cases of these tensor product modules, namely \smod_w \otimes S^d(K^i) and \smod_w \otimes \bigwedge^d(K^i), corresponding to Pieri and dual Pieri rules for Schubert polynomials
Optimi vitae dies: il salutare carmen di Virgilio e un caso di ‘ironia intertestuale’ nella Phaedra senecana
No full textIn Phaedra 450, Seneca alludes to Virgil georg. 3, 66-68. This is not an isolated case, since Seneca is here blending materials from
didactic poetry and, especially, from Georgics 3. The same Virgilian lines are quoted in the Epistulae and De brevitate vitae, where they are
defined as salutare carmen; in Phaedra’s quote there is no ethical purpose: on the contrary, the Nurse aims to persuade Hippolytus to enjoy
his youth and yield to love. The addition of an allusion to Horace’s Ode 4, 7, that ends up with the mention of Hippolytus’ death, makes this passage an interesting case of intertextual irony, a narrative tool frequently exploited by Ovid in his Heroides. By evoking different literary contexts, Seneca then transforms the salutare carmen into a rhetoric exercitatio, a suasoria that will not lead to any consequence for the development of the play. Even though poetry, by its arta necessitas, adds to the efficiency of the message, this can become a true ethical admonitio only through the interpretation given by the philosopher
Kraskiewicz-Pragacz modules and Pieri and dual Pieri rules for Schubert polynomials
No full textIn their 1987 paper Kraskiewicz and Pragacz defined certain modules, which we call KP modules, over the upper triangular Lie algebra whose characters are Schubert polynomials. In a previous work the author showed that the tensor product of Kraskiewicz-Pragacz modules always has KP filtration, i.e. a filtration whose each successive quotients are isomorphic to KP modules. In this paper we explicitly construct such filtrations for certain special cases of these tensor product modules, namely Sw Sd(Ki) and Sw Vd(Ki), corresponding to Pieri and dual Pieri rules for Schubert polynomials
Cerebrospinal Fluid: Novel Developed Biomarkers in Neurological Disease
No full textCerebrospinal Fluid: Novel Developed Biomarkers in Neurological Disease
(M. Dessi, F. Duranti, M. Pieri, G. Sancesario, R. Zenobi, S. Bernardini, Department of Experimental Medicine and Surgery, “Tor Vergata” University Hospital, Rome, Italy)pp.15-6
Fare scuola a classi aperte in rete. Sperimentazione di didattica condivisa in piccole scuole isolate e con pluriclassi
No full textNell’anno scolastico 2020-2021, INDIRE ha avviato una sperimentazione pilota nelle piccole scuole italiane di un
metodo didattico già validato in Québec e ritenuto utile per superare i limiti educativi che si verificano in situazioni di
remoteness (Mangione e Cannella, 2020). “Classi in rete” si caratterizza per una pratica didattica condivisa dove classi
“delocalizzate” vengono coinvolte in un percorso disciplinare comune adattando calendari, spazi e ruoli dei docenti
utilizzando ambienti di gemellaggio virtuale, di videoconferenza e spazi di argomentazione come il Knowledge Forum
(KF) (Mangione e Pieri 2019; Mangione et al., 2021). La sperimentazione del modello in Abruzzo ha coinvolto 12
piccole scuole e poggia su un approccio metodologico di analisi di tipo design-based research (Sandoval, 2014) L’articolo
vuole restituire una risposta alle seguenti domande:
D1 L’esperienza di classi in rete ha favorito cambiamenti nelle prassi e strategie didattiche dei docenti?
D2 Quali sono gli elementi che hanno condizionato il lavoro per gruppi a classi aperte?
L’analisi si avvale di un metodo misto che integra una ricerca standard tramite matrice dati e una ricerca di tipo interpretativo
tramite interviste di gruppo rivolte ai docenti coinvolti e agli studenti. Infatti, accanto a un’indagine quantitativa
strutturata volta a comprendere l’impatto che il modello ha avuto nelle classi sperimentali in termini di collaborazione,
interdisciplinarità, riorganizzazione dei tempi e degli spazi di lavoro, è stata condotta un’analisi qualitativa
basata su focus group con i docenti per rilevare quanto il modello abbia inciso sulla loro propensione al cambiament
Neotectonic features in the Apricena area: stratigraphic keys to distinguish the upper-Pliocene – lower Pleistocene subsidence and the middle – upper Pleistocene uplift phases in the NW part of the Apulian foreland (Gargano, Southern Italy)
No full textEvidenze di neotettonica (Pliocene superiore-Pleistocene superiore) nel settore occidentale del Promontorio del Gargano (Apricena, Italia meridionale)
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