36 research outputs found
Corradetti_et_al_Supplemental_Figure1 – Supplemental material for Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells
No full textSupplemental material, Corradetti_et_al_Supplemental_Figure1 for Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells by Bruna Corradetti, Salvatore Vaiasicca, Mauro Mantovani, Edy Virgili, Massimo Bonucci and Ivano Hammarberg Ferri in Integrative Cancer Therapies</p
A Systematic Review of Systematic Reviews and a Pooled Meta-Analysis on Complementary and Integrative Medicine for Improving Cancer-Related Fatigue
No full textPurpose: Evidence supporting complementary and integrative medicine (CIM) for improving cancer-related fatigue (CRF) is still fragmented. This study therefore critically appraised all the systematic reviews (SRs) regarding the effectiveness of CIM in mitigating CRF in adults. Methods: A systematic review of SRs and a meta-analysis were conducted in 4 databases. The effect sizes of the included SRs were quantitatively pooled (standardized mean difference [SMD]; 95% CI) using a random-effects model. Heterogeneity was tested by using χ2 (Q) tests and I2 statistics. Findings: Twenty-two SRs met the inclusion criteria, and results from 20 SRs underwent meta-analysis. The pooled significant estimate of fatigue reduction was as follows: SMD, −0.50; 95% CI, −0.67 to −0.32; P < 0.001. The subgroup analysis based on the type of CIM intervention revealed that the approach showing higher effects in reducing fatigue thus far is acupuncture: SMD, –0.99; 95% CI = –1.37 to –0.62, P < 0.001; I2 = 84%. CIM therapies showed a significant reduction of fatigue in patients with breast cancer: SMD, –0.46; 95% CI, –0.69 to –0.23; P < 0.001; I2 = 82%. Implications: CIM interventions showed effectiveness in reducing CRF. Subgroup analysis suggested some potential influencing, such as tumor type and specific CIM therapy factors, that require in-depth assessment in future research. Study protocol registration: PROSPERO CRD42020194254
Il Perugino di Bologna
No full textIn apparenza, il dipinto del Perugino conservato nella Pinacoteca di Bologna sembrerebbe proporre una presenza nel tempo strettamente intrecciata a quella di un altro, più famoso altare conservato nella stesso museo e proveniente dalla medesima chiesa: la Santa Cecilia di Raffaello. In realtà, quest’abbinamento storiografico, possibile modello di un rapido svolgimento figurativo, fu meno rilevante e sistematico di quello che in genere si ritiene. S’incrociano in questo saggio diverse traiettorie di analisi: dal tentativo di circoscrivere al massimo il periodo di esecuzione del dipinto alla sua ricaduta sull’ambiente artistico bolognese; dalla fortuna nelle guide cittadine e nella letteratura dei viaggiatori all’analisi tecnica, intesa sia come ricostruzione dei cartoni che come ricorso ad indagini riflettografiche; dalla temporanea migrazione in Francia alle successive vicende museali. Del dipinto viene inoltre individuata l’originaria cornice lignea
STUDIO ISTOMORFOLOGICO E MICRORADIOGRAFICO DELLA STAFFA OTOSCLEROTICA: RISULTATI PRELIMINARI
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La “Commedia” di Dante alla corte degli Este (con una scheda paleografica su Anicio Bonucci falsario)
No full textStudio della tradizione manoscritta della Commedia di Dante Alighieri in area ferrarese, col confronto dei manoscritti attualmente conservati a Modena e gli antichi inventari estensi. Particolare attenzione è dedicata al ms. Italiano 1523, che è stato riconosciuto come un falso dell'erudito fanese Anicio Bonucci.This essay looks at the reception of Dante’s Commedia in Ferrara under the d’Este dukedom. The study of the early inventories of the Estense library have revealed the presence of several copies of Dante’s great poem which the author has tried to identify with those which survive today in the library in Modena. Among the manuscripts which have been examined, Italiano 1513, signed by Antonio
da Gubbio in 1406, is of particular interest. Paleographical analysis has shown that this manuscript is in fact the work of the well-known forger and native of Fano Anicio Bonucci (1803-1874)
Prevalence and effectiveness of psychiatric treatments for patients with IBD: A systematic literature review
No full textObjectives Higher prevalence of psychiatric disorders, such as anxiety and depression, has been found in people with Crohn's disease and Ulcerative Colitis compared to the general population. Nowadays, international guidelines advocate psychotherapy and psycho-pharmacological treatments as playing an important role in IBD care. The main goal of this systematic literature review was summarize the evidence on the utilization and effectiveness of treatments for depression and anxiety in persons with IBD. Methods A systematic literature review was conducted using three different electronic databases: MEDLINE, PsychINFO, and EMBASE to identify studies reporting the prevalence and efficacy of psycho-pharmacological and psychotherapeutic treatments for IBD. A quality appraisal was conducted using several scales as appropriate for each study design. A narrative synthesis was also performed. Results Forty-three studies were included. Although a high rate of psychoactive drug use was found in people with IBD, a low proportion of IBD patients have access to psychiatric referral. 1/3 of the studies found that psychotherapy was effective for improving the quality of life, perception of stress, anxiety and depression as well as disease. Antidepressants proved effective in reducing disease activity, gastrointestinal symptoms, anxiety and depression. Conclusion Our results suggest that psychiatric treatment should be implemented in IBD care. However, further studies are needed to confirm the findings of our systematic review
Prevalence of demoralization and depressive symptoms in a sample of patients with supraventricular tachyarrhythmias: preliminary results
No full textIntroductionSupraventricular tachyarrhythmias (ST) are the most common cardiac arrhythmias. Little is known about the potential impact of demoralization, which is considered as partially distinct from depression, on the course of ST. A correct assessment of both depressive symptoms and demoralization appears relevant for the treatment of these cardiac diseases, potentially influencing their course.MethodsThe sample consisted of 110 subjects affected by different ST, such as atrial fibrillation (AF), atrial flutter (AFL) and paroxysmal supraventricular tachycardia (PSVT). They all underwent a psychiatric evaluation; the Italian version of 9-item Patient Health Questionnaire (PHQ-9) and the Italian version of Demoralization Scale (DS) were administered. Descriptive statistics, pairwise comparisons, and correlational analysis have been implemented.Results26 individuals (23.6%) presented high levels of demoralization. Of these, 20 (76.9%) had a diagnosis of AF and six patients (23.1%) received a diagnosis of other ST. No differences in demoralization levels resulted in regard of sex, cardiac diagnoses and anticoagulant therapies. Amongst people with high levels of demoralization, 13 (50%) received no formal psychiatric diagnosis, and 12 (46.2%) showed moderate/severe depressive symptoms. Demoralization levels and PHQ-9 scores showed a significant positive correlation in the whole sample (r=0.550, p<0.001).DiscussionThe present study found that in a sample of patients suffering from ST, high levels of demoralization were more frequent than clinically relevant depressive symptoms. We propose that demoralization and depression show partially distinguished psychopathological features, potentially associated with different therapeutic trajectories
Integrative Oncology: Scientific Research in Support of Patients: Useful, Possible, Valid
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