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No full textAnalisi semiotica dell'opera fotografica dell'artista Massimo Boldrin in occasione di una sua mostra personale dedicata ai luoghi di culto, con una contestualizzazione critica della sua lettura in particolare in riferimento all'iconografia sacra russa
T Regulatory Lymphocytes Function Increased, by Induction Of Ho-1, Improves Type-1 Cardio-Renal Syndrome
No full textRationale: Type-1 cardio-renal syndrome (CRS) is characterized by an acute kidney dysfunction due to renal arteriolar vasoconstriction following an acute worsening of cardiac function. It is well know that HO-1 upregulation has a cardio protective and renoprotective function mediated by anti-oxidative, anti-inflammatory, anti-apoptotic and vasodilating effects. An alteration of T-lymphocyte-related immune response seems to be one of the potential mechanisms involved in type-1 CRS.
Objective: The aim of this study was to assess 1) if HO-1 upregulation could be a therapeutic target for type 1 CRS and 2) the role of T-lymphocytes in HO-1 induced effects on renal function in type 1 CRS.
Methods: Post-ischemic heart failure was induced by left anterior coronary artery ligation in C57Bl6 and SCID (T lymphocytes deficient) mice. Animals were divided into 4 groups: sham, myocardial infarction (MI), MI treated with HO-1 inducer cobalt protoporphyrin (CoPP) with and without the HO activity inhibitor stannous mesoporphyrin (SnMP). All mice underwent echocardiography (fractional area shortening, FAS) and renal Doppler sonography (intrarenal pulsatility index, PI) 30 days after surgery.
Results: Heart function was significantly reduced in MI groups (C57: FAS: sham 0.36±0.06, MI 0.26±0.04, p<0.05; SCID: FAS: sham 0.34±0.04, MI: 0.24±0.04, p<0.01) and PI was significantly increased in MI groups compared to sham groups (C57: PI: sham 0.98±0.05, MI: 1.12±0.11, p<0.05; SCID: PI: sham 0.72±0.08, MI 1.37±0.37, p<0.05). HO-1 induction improved heart function in both C57 and SCID mice but only in SCID mice was a significant improvement of renal vasoconstriction observed (SCID; PI: MI+CoPP 0.9±0.19 p<0.05). In SCID mice SnMP treatment reversed the effect of CoPP on heart function and renal vasoconstriction.
Conclusion: Our novel study showed that T lymphocyte mediated immunity is involved in type 1 CRS and upregulation of HO-1, in this setting, could be a therapeutic target for improving type 1 CRS.
Author Disclosures: P. Pesce: None. D. Sacerdoti: None. M. Boldrin: None. R. Rezzani: None. N.G. Abraham: None.
Key Words: Renal circulation • Heart failure • Immunologic factors • Oxidative stres
Venezia e l’Egitto. Dietro le quinte della mostra
No full textIl volumetto descrive la genesi della mostra su Venezia e l'Egitto svoltasi a Palazzo Ducale a Venezia nel 2011-12, attraverso fotografie di Massimo Boldrin e un testo introduttivo, con un commento alle immagini, dell'autor
LESIONI INDOTTE DA CMV A LIVELLO DEL TRATTO GASTROINTESTINALE IN 45 PRIMATI XENOTRAPIANTATI
No full textIntroduzione: Lo xenotrapianto potrebbe rappresentare un’opzione terapeutica alla grave carenza di organi e studi sono in corso per minimizzare il rischio di infezioni legato alla immunosoppressione. In particolare, il cytomegalovirus (CMV) nei primati xenotrapiantati e immunosoppressi è una causa ben nota di patologia che coinvolge soprattutto l’apparato gastroenterico.
Materiali e metodi: I tessuti provenienti da 45 Macaca fascicularis immunosoppresse e xenotrapiantate sono stati analizzati istologicamente e tramite esame immunoistochimico (IHC) utilizzando un anticorpo specifico per una proteina della fase immediate-early 1 del CMV di Macaca Rhesus (RhCMV), una specie filogenicamente molto vicina a Macaca fascicularis. Altre analisi hanno compreso i test sierologici per RhCMV e l’analisi molecolare dei tessuti colpiti dall’infezione.
Risultati: 5/45 primati hanno evidenziato le caratteristiche lesioni da CMV del tratto gastroenterico, tra cui enterite neutrofilica con corpi inclusi. Altri 3 primati invece hanno mostrato una positività specifica per CMV solo a livello IHC. L’esame sierologico ha evidenziato positività in tutti gli animali per la presenza di anticorpi per CMV, in seguito all’utilizzo di un test specifico per RHCMV. Lo studio molecolare dei tessuti con lesioni istopatologiche da CMV ha confermato, attraverso amplificazione e sequenziamento del DNA, la presenza di CMV della specie ricevente, Macaca fascicularis.
Discussione e conclusioni: nei primati immunosoppressi e trapiantati con diarrea, le infezioni da CMV non devono essere sottovalutate. Le infezioni devono essere indagate con strumenti appropriati e specifici per primati non umani, e quindi trattate con terapia antivirale mirata
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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