324,173 research outputs found
Correction to: Combined botulinum toxin type A and electrical stimulation in individuals with C5-C6 and C6-C7 tetraplegia: a pilot study (Spinal Cord Series and Cases, (2020), 6, 1, (70), 10.1038/s41394-020-0317-2)
No full textThe original version of this Article contained an error in the spelling of the authors Francesco Piccione, Paolo Tonin, Antonio Cerasa and Stefano Masiero, which were incorrectly given as Piccione Francesco, Tonin Paolo, Cerasa Antonio, and Masiero Stefano, respectively. This has now been corrected in both the PDF and HTML versions of the Article
NANOSCALE MONITORING OF RESPONSIVE SUPRAMOLECULAR NANOSTRUCTURES AT THE SOLID-LIQUID INTERFACE
No full textThe self-assembly of small molecular modules into non-covalently linked polymeric nanostructures is a subject of continuous interest [1]. In particular, supramolecular structures with a high degree of order can be obtained through the self-association of organic molecules on flat solid surfaces. Such structures can be used as scaffolds to position electrically/optically active groups in pre-determined locations in 2D [2] thereby paving the way towards a wide range of applications, e.g. in electronic and optical devices. Among weak interactions, H-bonding offers high control over the process of molecular self-assembly because it combines reversibility, directionality, specificity and cooperativity. Such a unique character is the basis of sophisticated programs for self-assembly such as those based on the Watson–Crick base pairing which directs the formation of the helical structure of DNA.
While the self-assembly of guanines into G-quartet based architectures on solid surfaces has been studied by Scanning Tunneling Microscopy (STM) under ultrahigh vacuum (UHV) [3], STM explorations at the solid-liquid interface have been primarily carried out on guanosine derivatives [4]. In this lecture we will present a sub-molecularly resolved STM study at the solid-liquid interface of the metal templated reversible assembly/reassembly process of a N9-alkylguanine into highly ordered quartets and ribbons on highly oriented pyrolitic graphite (HOPG) surfaces. The self-assembly of guanine derivatives on HOPG has been studied as neat component[5] and upon sub-sequent addition of cryptand [2.2.2] molecules, potassium picrate and triflic acid to trigger the reversible interconversion between two different highly ordered supramolecular motifs, i.e. H-bonded ribbon and G-quartet based architectures. In-situ STM imaging provided the first direct evidence on the sub-nm scale of a dynamer operating at surfaces. [6]
Finally we will also provide the first example of sub-molecularly resolved vertically oriented switchable chromophores in physisorbed monolayers by monitoring the cis-trans isomerization of a physisorbed azobenzene at surfaces. [7]
The nanoscale visualization of such supramolecular interconversion at the solid-liquid interface opens new avenues towards understanding the mechanism of formation and functioning of complex architectures. Furthermore, the in-situ reversible assembly and re-assembly between two highly ordered supramolecular structures at a given surface represents the first step towards the generation of nanopatterned responsive architectures.
[1] J. M. Lehn, Science, 295, 2002, 2400.
[2] G. P. Spada, S. Lena, S. Masiero, S. Pieraccini, M. Surin, P. Samorì, Adv. Mater., 2008, 20, 2433; A. Ciesielski, L. Piot, P. Samorì, A. Jouaiti, M. W. Hosseini, Adv. Mater., 2009, 21, 1131.
[3] R. Otero, M. Schock, L. M. Molina, E. Laegsgaard, I. Stensgaard, B. Hammer, F. Besenbacher, Angew. Chem. Int. Ed., 2005, 44, 2270.
[4] G. Gottarelli, S. Masiero, E. Mezzina, S. Pieraccini, J. P. Rabe, P. Samorì, G. P. Spada, Chem. Eur. J., 2000, 6, 3242; T. Giorgi, S. Lena, P. Mariani, M. A. Cremonini, S. Masiero, S. Pieraccini, J. P. Rabe, P. Samorì, G. P. Spada, G. Gottarelli, J. Am. Chem. Soc., 2003, 125, 14741; S. Lena, G. Brancolini, G. Gottarelli, P. Mariani, S. Masiero, A. Venturini, V. Palermo, O. Pandoli, S. Pieraccini, P. Samorì, G. P. Spada, Chem. Eur. J., 2007, 13, 3757.
[5] A. Ciesielski, R. Perone, S. Pieraccini, G.P. Spada, P. Samorì, Chem. Commun 2010, 46, 4493.
[6] A. Ciesielski, S. Lena, S. Masiero, G. P. Spada, P. Samorì, Angew. Chem. Int. Ed. 2010, 49, 1963.
[7] D. Bléger, A. Ciesielski, P. Samorì, S. Hecht, 2010 submitted
TCP14 and TCP15 mediate the promotion of seed germination by gibberellins in Arabidopsis thaliana
No full textResentini, F.; Felipo-Benavent, A.; Colombo, L.; Blazquez Rodriguez, MA.; Alabadí Diego, D.; Masiero, S. (2015). TCP14 and TCP15 mediate the promotion of seed germination by gibberellins in Arabidopsis thaliana. Molecular Plant. 8(3):482-485. doi:10.1016/j.molp.2014.11.018S4824858
Dysphagia in neurological diseases: a literature review. Panebianco M, Marchese-Ragona R, Masiero S, Restivo DA. Neurol Sci. 2020 Jun 7. doi: 10.1007/s10072-020-04495-2.
No full textDysphagia is defined as an impairment of this complex and integrated sensorimotor system. It is estimated that 400,000 to 800,000 individuals worldwide develop neurogenic dysphagia per year. Neurogenic dysphagia is typically occurring in patients with neurological disease of different etiologies. A correct and early diagnosis and an appropriate management of dysphagia could be useful for improving patient’s quality of life and may help to prevent or delay death. In the present review, we discuss thoroughly the anatomy and physiology of swallowing and also the pathophysiological mechanisms involved in impaired swallowing, as well as the diagnosis, management, and potential treatments of neurogenic dysphagia. Assessment of neurogenic dysphagia includes medical history, physical exam, and instrumental examinations (fiberoptic endoscopic evaluation of swallowing, videofluoroscopic swallowing study, electromyography). Pharmacological treatment of these problems includes oral anticholinergic drugs. Surgical myotomy of the cricopharyngeal muscle showed an important improvement of oropharyngeal dysphagia associated to upper esophageal sphincter hyperactivity. Chemical myotomy of the upper esophageal sphincter by local injections of botulinum toxin type A into the cricopharyngeal muscle has been proposed as an alternative less invasive and less unsafe than surgical myotomy
Radiative B-L symmetry breaking in supersymmetric models
No full textWe propose a scheme where the three relevant physics scales related to the supersymmetry, electroweak, and
baryon minus lepton (B − L) breakings are linked together and occur at the TeV scale. The phenomenological
implications in the Higgs and leptonic sectors are discussed
Il paziente parzialmente edentulo candidato all’implantologia : valutazione della quantità ossea
No full textB ---> K pi Puzzle and New Sources of CP Violation in Supersymmetry
No full textThe difference between the CP asymmetries of the B0 ! K+− and B+ ! K+0 decays has been recently
confirmed with an evidence larger than 5’s. We discuss it as a possible signal of new physics associated with
new (large) CP violation in the electroweak penguin contributions. We propose a supersymmetry breaking
scheme where such new sources of CP violation occur in the flavor non-universal trilinear scalar couplings
Infinite Jest’s Voice(s) – Notes for an (Audible) Map
No full textWe often refer to a book as having a voice that sounds uniquely distinctive, a voice that stays with us after a book is over. Voice is a key narratological term; together with its twin partner – focalization – it constitutes the skeleton of a given storyworld. The first – experiential – conception of voice is difficult to grasp and articulate and has something to do with a specific tonality we perceive in a direct, almost visceral way. The second – scholarly – produces a host of definitional moves, which tend to crystallize it in a dominant mode of articulating a story. “Infinite Jest’s voice(s)” aims at bridging the two conceptions of voice just sketched, trying to give the sense of the book’s having a distinctive, unforgettable, voice as far as the reader’s experience is concerned
La lombalgia in una squadra di rugbisti del campionato italiano dâ€TMeccellenza super 10
No full textAnche il rachide, come gli altri segmenti corporei sopra citati, è
esposto, in questo sport, ad importanti traumatismi8,9. In particolare
il rachide cervicale riceve grandi sollecitazioni sia nella fase della
mischia che in quella del placcaggio. Il meccanismo lesivo è soprattutto
quello di iperflessione che espone a fratture con dislocazione,
prevalentemente il tratto C1-C2 e quello tra C4 e C6. Le forti pressioni
che agiscono sul cranio e sul collo durante la mischia sembrano
favorire, invece, la comparsa di ernie discali cervicali.
Sul versante della rachialgia è ipotizzabile, soprattutto per il notevole
impegno fisico profuso nella pratica del rugby, che tale disturbo
coinvolga in misura rilevante chi pratica tale disciplina sportiva a
livello agonistico.
Il nostro studio era volto ad accertare in una squadra maschile di
rugbisti agonisti, la presenza della rachialgia, le sue implicazioni cliniche e la presenza di eventuali modificazioni funzionali e morfologiche
del rachide attività-dipendenti
- …
