1,720,997 research outputs found
Acute necrotizing pancreatitis related to tigecycline
No full textBecause we are confronted with the increasing use of tigecycline
for the treatment of infections due to multidrug-resistant
bacteria, it is important to note that two recent meta-analyses
raise concerns about the efficacy and safety of therapy
with this antibiotic. A higher overall mortality and a higher
incidence of adverse effects, especially nausea and vomiting,
have been observed with tigecycline compared with other
regimens.1,2
Tigecycline-induced acute pancreatitis is considered an
uncommon event, with an estimated incidence between 1%
and 1‰. The mechanism remains unknown.3 Five cases of
interstitial or oedematous pancreatitis have been reported, all
of which occurred during the second week of therapy in
patients without other risk factors for pancreatitis. None of
the patients required intensive care.3,4 To our knowledge, we
report on the first case of acute necrotizing pancreatitis
related to tigecycline
Progressive multifocal leukoencephalopathy in an HIV patient receiving successful long-term HAART
No full textProgressive multifocal leukoencephalopathy (PML) has been traditionally associated to severe immunosuppression and described mainly in highly active antiretroviral therapy (HAART)-naïve patients with a low lymphocyte CD4+ count. In the last years, some cases of PML have been described in HIV patients with a higher CD4+ count shortly after initiation of HAART and in association with the immune reconstitution inflammatory syndrome (IRIS). We report on a rare case of PML, not IRIS associated, that occurred in a HIV-positive patient with a lymphocyte CD4+ count greater than 700/μl and with an undetectable HIV viral load resulting from a long-term HAART. We describe the pathological and the ultrastructural features of the brain lesion. This case confirms that a severe immunosuppression or an IRIS is not required for the development of PML in HIV positives. The diagnosis of PML should always be considered in patients with consistent neurological symptoms, even with a high lymphocyte CD4+ level and a full viral suppression resulting from a long-term HAART
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A procedure to recover data of a cubesat mission at very low S/N ratio
No full textThis paper deals with the activities led in the framework of E-ST@R-II cubesat mission to decode the downlink telemetry signal, which was affected since launch by a power drop in the order of 20dB with respect to the computed link budget. Despite optimization of the ground station, with installation of higher gain antennas and more performant low noise amplifiers, it was not always possible to directly decode the received signal using existing modems, either hardware or software based. Therefore, a dedicated signal demodulation algorithm was developed and used to post-process all recorded data since launch. The algorithm has been verified and optimized by checking its performance against test data and then it was used to extract useful information from recorded satellite telemetry
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