117,366 research outputs found
L. Cognet. Crépuscule des mystiques, Bossuet-Fénelon, nouvelle édition mise à jour et présentée par J. R. Armogathe
No full textMarxer François. L. Cognet. Crépuscule des mystiques, Bossuet-Fénelon, nouvelle édition mise à jour et présentée par J. R. Armogathe. In: Revue de l'histoire des religions, tome 210, n°2, 1993. pp. 238-240
L. Cognet. Crépuscule des mystiques, Bossuet-Fénelon, nouvelle édition mise à jour et présentée par J. R. Armogathe
No full textMarxer François. L. Cognet. Crépuscule des mystiques, Bossuet-Fénelon, nouvelle édition mise à jour et présentée par J. R. Armogathe. In: Revue de l'histoire des religions, tome 210, n°2, 1993. pp. 238-240
Training in coordinate metrology - experiences with a blended learning approach
No full textW1.1. - ID13
Education and training in coordinate metrology for industry towards digital manufacturing
No full textTraining in the aeronautic industry for geometrical quality control and large scale metrology
No full textAdvanced manufacturing of aircraft, and the large parts needed in this field, is based on multiple suppliers located in different countries and continents, intensively using automation, data exchange, advanced manufacturing technologies embedded in the digital era. Several national and international initiatives (e.g. Industrie 4.0) are oriented to support this effort and development. New opportunities for advanced manufacturing of aeronautic products are based on measuring technologies for Geometrical Quality Control and Large Scale Metrology. In the Aeronautic Industry they are an essential tool for the implementation of the initiatives in modern product engineering and process control. To operate, programme and manage the most advanced measuring systems, highly competent and skilled personnel is required. The authors will describe new developments in the framework of the international project "WINGS+", addressing the training needs of the Aeronautic industry, and suggest innovative training solutions with focus on the competent use of relevant measuring systems.</p
Indications and Outcomes of Helicopter Rescue Missions in Alpine Mountain Huts: A Retrospective Study
No full textPasquier, Mathieu, Louis Marxer, Hervé Duplain, Vincent Frochaux, Florence Selz, Pierre Métrailler, Grégoire Zen Ruffinen, and Olivier Hugli. Indications and outcomes of helicopter rescue missions in alpine mountain huts: A retrospective study. High Alt Med Biol 18:355-362, 2017.
This retrospective study describes the rescue indications and outcome of patients rescued by helicopter from mountain huts in the Swiss Alps. The hospital course and operational data were also studied.
Among 14,872 helicopter rescue missions undertaken during the 10-year study period, 309 (2.1%) were performed from mountain huts at a mean altitude of 2794 ± 459 m. The mean age of the patients was 43 ± 16 and 66% were male. Thirty-four percent of the patients had a National Advisory Committee for Aeronautics score ≥3. Most (89%) patients were transported to hospital and only 12 (3.9%) patients had to stay more than 48 hours. Hospital diagnoses were extremely varied. Trauma accounted for 50% and altitude diseases for 7% of the cases. A winching procedure was performed 18 times and 19 missions included a night flight.
Helicopter rescue missions in mountain huts are a small part of all rescue missions. Our study provides a better understanding of medical emergencies arising in mountain huts. The diagnoses encountered are extremely varied in their type and severity. Hut keepers should be prepared for these situations as they will often have to act as first responders in the case of medical problems
A novel marker glycoprotein for the microvillus membrane of surface colonocytes of rat large intestine and its presence in small-intestinal crypt cells
No full textMurine mAbs were produced against purified microvillus membranes of rat colonocytes in order to establish a marker protein for this membrane. The majority of antibodies binding to the colonic microvillus membrane recognized a single protein with a mean apparent Mr of 120 kD in both proximal and distal colon samples. The antigen is membrane bound as probed by phase-partitioning studies using Triton X-114 and by the sodium carbonate extraction procedure and is extensively glycosylated as assessed by endoglycosidase F digestion. Localization studies in adult rats by light and electron microscopy revealed the microvillus membrane of surface colonocytes as the principal site of the immunoreaction. The antigen was not detectable in kidney or liver by immunoprecipitation but was present in the small intestine, where it was predominantly confined to the apical membrane of crypt cells and much less to the microvillus membrane of differentiated enterocytes. During fetal development, the antigen appears first in the colon at day 15 and 1-2 d later in the small intestine. In both segments, it initially covers the whole luminal surface but an adult-like localization pattern develops soon after birth. The antibodies were also used to develop a radiometric assay for the quantification of the antigen in subcellular fractions of colonocytes in order to assess the validity of a previously developed method for the purification of colonic brush-border membranes (Stieger, B., A. Marxer, and H.P. Hauri. 1986. J. Membr. Biol. 91:19-31.). The results suggest that we have identified a valuable marker glycoprotein for the colonic microvillus membrane, which in adult rats may also serve as a marker for early differentiation of enterocyte progenitor cells in small-intestinal crypt cells
Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula
No full textBACKGROUND: The development of novel antischistosomal drugs is crucial, as currently no vaccine and only a single drug is available for the treatment of schistosomiasis. Fast and accurate in vitro assays are urgently needed to identify new drug candidates and research efforts should include Schistosoma haematobium. The aim of the present study was to develop a S. haematobium drug sensitivity assay based on newly transformed schistosomula (NTS).
METHODS: We first undertook comparative studies on the cercarial emergence rhythms of the intermediate host snails Biomphalaria glabrata (S. mansoni) and Bulinus truncatus (S. haematobium). Two transformation methods as well as three purification methods were studied on S. haematobium cercariae in order to produce a large number of viable and clean NTS. Known antischistosomal drugs were tested in the established NTS assay in vitro. Drug effects were evaluated either microscopically or fluorometrically, using a resazurin based viability marker. Microscopically obtained IC50 values were compared with results obtained for S. mansoni.
RESULTS: A circadian rhythm existed in both snail species. Infected B. truncatus snails shed less cercariae than B. glabrata during the testing period. The highest transformation rate (69 %) of S. haematobium cercariae into NTS was obtained with the vortex transformation (mechanical input) and the highest purification factor was observed using Percoll[REGISTERED SIGN]. The fluorimetric readout based on resazurin was very precise in detecting dead or/and severely damaged schistosomula.
CONCLUSIONS: With the use of viability markers such as resazurin, drug screening assays using S. haematobium NTS can be efficiently performed. However, drugs acting on the morphology and motility of S. haematobium NTS, such as metrifonate are missed. Drug sensitivity assays with NTS of both species, S. haematobium and S. mansoni, showed very similar results using known antischistosomal drugs. The S. mansoni NTS assay might be more suitable as primary screen in drug discovery efforts, which ultimately aim for a broad-spectrum antischistosomal drug as a larger number of S. mansoni NTS can be generated
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Geometrical Product Specification and Verification as toolbox to meet up-to-date technical requirements
No full textThe ISO standards for the Geometrical Product Specification and Verification (GPS) define an internationally uniform description
language, that allows expressing unambiguously and completely all requirements for the geometry of a product with the corresponding
requirements for the inspection process in technical drawings, taking into account current possibilities of measurement and testing
technology. The practice shows that the university curricula of the mechanical engineering faculties often include only limited classes on
the GPS, mostly as part of curriculum of subjects like Metrology or Fundamentals of Machine Design. This does not allow students to
gain enough knowledge on the subject. Currently there is no coherent EU-wide provision for vocational training (VET) in this area.
Consortium, members of which are the authors of this paper, is preparing a proposal of an EU project aiming to develop appropriate
course
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