1,820 research outputs found
Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing
No full textAn ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate were manufactured continuously and in batches. The effect of two processing parameters, compaction force and level of shear strain were examined. Young's modulus and tensile strength of tablets were obtained by ultrasound and diametrical mechanical testing, respectively. It was found that as the blend was exposed to increasing levels of shear strain, the speed of sound in the tablets decreased and the tablets became both softer and mechanically weaker. Moreover, the results indicate that two separate tablet material properties (e.g., relative density and Young's modulus) are necessary in order to predict tensile strength. A strategy for hardness prediction is proposed that uses the existing models for Young's modulus and tensile strength of porous materials. Ultrasound testing was found to be very sensitive in differentiating tablets with similar formulation but produced under different processing conditions (e.g., different level of shear strain), thus, providing a fast, and non-destructive method for hardness prediction that could be incorporated to a continuous manufacturing process.Peer reviewe
Tercer descarte. Querido Alberto:
No full textThis third chapter of the book "Descartes bibliográficos y de bibliofilia" by Prof. Pedro M. Cátedra is dedicated to Prof. Alberto Blecua. He studies a peculiar little Book of Hours of Seventeenth century Spain, written by a nine-year-old child, in an excellent calligraphy, which the principal poets of Madrid (Juan Ruiz de Alarcón, Pedro Calderón de la Bara, Lope de Vega, Luis Vélez de Guevara or Jerónimo de Villaizán) celebrate with some poetical compositions, 'décimas' or sonnets. It is suggested that the author could be one of the numerous bastards of Philip IV. It is studied also in the context of the changes of Spanish calligraphy in Seventeenth Century.
Este tercer capítulo del libro Descartes bibliográficos y de bibliofilia del profesor Pedro M. Cátedra está dedicado al profesor Alberto Blecua. Se estudia un peculiar libro de horas del siglo XVII, escrito por un niño de nueve años, en una caligrafía excelente, que celebran los principales poetas de Madrid –Juan Ruiz de Alarcón, Pedro Calderón de la Barca, Lope de Vega, Luis Vélez de Guevara y Jerónimo de Villaizán– con décimas o sonetos. Se sugiere que el autor pueda ser uno de los numerosos hijos bastardos de Felipe IV. Se estudia también en el contexto de los grandes cambios sobre la caligrafía en la España de principios del siglo XVII
Evaluation of Radiation Thermal Resistances in Industrial Motors
No full textThis paper deals with the role of the radiation thermal resistances in industrial motors and describes a test set useful for the resistance evaluation. The test set is based on a vacuum chamber and on a numerical acquisition system, and the resistances are obtained by monitoring motor temperatures during a heating test. An analytical model that describes how the radiation resistance depends on the motor temperature is also provided. Experimental results obtained on a totally enclosed fan-cooled 150-W induction motor are shown and discussed
The effect of mechanical strain on properties of lubricated tablets compacted at different pressures
No full textA full factorial design of experiments was used to study the effect of blend shear strain on the compaction process, relative density and strength of pharmaceutical tablets. The powder blends were subjected to different shear strain levels (integral of shear rate with respect to time) using an ad hoc Couette shear cell. Tablets were compressed at different compaction forces using an instrumented compactor simulator, and compaction curves showing the force-displacement profiles during compaction were obtained. Although the die-fill blend porosity (initial porosity) and the minimum in-die tablet porosity (at maximum compaction) decreased significantly with shear strain, the final tablet porosity was surprisingly independent of shear strain. The increase in the in-die maximum compaction with shear strain was, in fact, compensated during post-compaction relaxation of the tables, which also increased significantly with shear strain. Therefore, tablet porosity alone was not sufficient to predict tablet tensile strength. A decrease in the ‘work of compaction’ as a function of shear strain, and an increase in the recovered elastic work was observed, which suggested weaker particle-particle bonding as the shear strain in- creased. For each shear strain level, the Ryskewitch Duckworth equation was a good fit to the tensile strength as a function of tablet porosity, and the obtained asymptotic tensile strength at zero porosity exhibited a 60% reduction as a function of shear strain. This was consistent with a reduced bonding efficiency as the shear strain increased.Peer reviewed
Métricas de autor Luis Alberto Quiroga Baquero
No full textInforme de las métricas de autor del Dr. Luis Alberto Quiroga Baquero de las publicaciones indexadas en Google Académico cuyo objetivo es entregar un insumo para el fortalecimiento de las capacidades y potencialidades de los autores de la Universidad Santo Tomás en el posicionamiento y visibilidad de sus publicaciones.Report of the author metrics Luis Alberto Quiroga Baquero of the publications indexed in Google Scholar whose objective is to provide an input for the strengthening of the capacities and potentialities of the authors of the Santo Tomás University in the positioning and visibility of their publications.http://unidadinvestigacion.usta.edu.c
AUTHOR CORRECTION - ERS International Congress 2019:highlights from Best Abstract awardees
No full textLorna E. Latimer, Marieke Duiverman, Mahmoud I. Abdel-Aziz, Gulser Caliskan, Sara M. Mensink-Bout, Alberto Mendoza-Valderrey, Aurelien Justet, Junichi Omura, Karthi Srikanthan, Jana De Brandt. Breathe 2019; 15: e143–e149. This article from the December 2019 issue of Breathe was published with an error in the name of one of the authors. The corrected author list is shown above. The article has been corrected and republished online.</p
Correction to: Is there a skeletal age index that can predict accurate curve progression in adolescent idiopathic scoliosis? A systematic review (Pediatric Radiology, (2023), 54, 2, (299-315), 10.1007/s00247-023-05834-z)
No full textThe original article contains a spelling error in an author’s name. The author “Alberto Arcieri” should read as “Alberto Arceri”. The original article has been corrected
Correction to: Pediatric elbow arthroscopy: clinical outcomes and complications after long-term follow-up (Journal of Orthopaedics and Traumatology, (2021), 22, 1, (55), 10.1186/s10195-021-00619-2)
No full textFollowing publication of the original article [1], the authors identified an error in the author names. The given name and family name were erroneously transposed. The incorrect author names: Micheloni Gian Mario, Tarallo Luigi, Negri Alberto, Giorgini Andrea, Merolla Giovanni and Porcellini Giuseppe. The correct author names: Gian Mario Micheloni, Luigi Tarallo, Alberto Negri, Andrea Giorgini, Giovanni Merolla, Giuseppe Porcellini. The author group has been updated above and the original article [1] has been corrected
Presencia de Alberto Magno en el pensamiento de Nicolás de Cusa
No full textThis article surveys the presence of Albertus Magnus’ philosophical and theological doctrines in Nicholas of Cusa’s thought. It is divided in three sections. In the first section the author describes the theological studies of the Cusanus (1425) at the University of Cologne under Heymeric of Campo, and traces the Albertian influences in that environment. The second section is devoted to the analysis of the Cusanus’ marginalia on Albert\u27s Commentaries on Pseudo-Dionysius. The third section illustrates the influence of Albertus Magnus upon the treatise De li non aliud, written by Nicholas in 1462.Este artículo investiga la presencia de las doctrinas filosóficas y teológicas de Alberto Magno en el pensamiento de Nicolás de Cusa. Se divide en tres secciones. En la primera sección, el autor describe los estudios teológicos del Cusano (1425) en la Universidad de Colonia bajo la dirección de Heymeric de Campo, y traza las influencias albertianas en ese ambiente. La segunda sección se ocupa del análisis de las marginalia de Nicolás de Cusa en los Comentarios de Alberto a Pseudo-Dionisio. La tercera sección ilustra la influencia de Alberto en el tratado De li non aliud, escrito por el Cusano en 1462
Political models of macroeconomic policy and fiscal reform
No full textThe author explains how recent developments in political economics improve our understanding of macroeconomic policy - especially the timing, design, and likelihood of stabilization's success through monetary and fiscal reform. The author reviews the literature on political business cycles and emphasizes several issues involving the relationship between the timing of elections and the timing of macroeconomic policies and outcomes. He also addresses how models can be useful in studying non-democratic systems. Two forces are crucial factors in both democratic and dictatorial systems, although they may manifest themselves differently: (1) the policymakers'incentive to retain power; and (2) society's polarization and the degree of social conflict. The author then analyzes why economic stabilization is delayed, even when it is obvious that sooner or later a stabilization program will have to be adopted. Some points made in the paper follow. Certain institutional characteristics make quick and successful stabilization more or less likely. The more unequal the distribution of stabilization's costs, the more likely that stabilization will be delayed. An increase in the cost of postponing stabilization reduces the delay. Political institutions that make it easier for small interest groups to veto legislation make delay more likely. If political and economic resources are unequally distributed, and it is obvious which group is stronger and has resources to wait longer, a war of attrition ends immediately, as there is no uncertainty about who will win it. Delay is more likely when information about who will bear the cost of delays is uncertain or unevenly distributed. Delay is also more likely when there is agreement about the need for fiscal change but a political stalemate about distribution - about how the burden of higher taxes or spending cuts should be allocated. Stabilization usually occurs when there is political consolidation. The burden of stabilization is sometimes unequal, with the politically weaker group (often the lower classes) bearing a larger burden (often regressive measures). If it is in the interest of the current government to do nothing for fear of failure because of government incompetence, the public may have no incentive to vote for the opposition because the opposition may also do nothing; the crucial factor here is how aware the government is of its own incompetence and thus its reasons for not attempting reform. Successful stabilization usually comes after several failed attempts, and the successful program is often very much like one that failed.Environmental Economics&Policies,Economic Theory&Research,National Governance,ICT Policy and Strategies,Health Economics&Finance
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