81 research outputs found
Then fall the trees
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Previous issue date: 2015Ope
Dose dependency of GYY4137 in term pregnant rat.
No full text<p>(<b>A</b>) Representative isometric recordings of spontaneously contracting myometrial strips obtained from 22 day gestation rat, before and after 45 minute incubations in i) 1 nM, ii)1 µM, iii) 0.1 mM, iv) 1 mM GYY4137 (GYY). (<b>B</b>) Mean data ± s.e.m, denoted by error bars, showing the dose dependent decrease in i) Amplitude, ii) Frequency, iii) AUC in response to GYY. Iv) the dose response curve for the % inhibition of amplitude. Values within bars indicate n-numbers. * represents P<0.05, ** represents p<0.01, using Anova with Bonferroni <i>post hoc</i> tests.</p
Rumen degradation of oil palm fronds is improved through pre-digestion with white rot fungi but not through supplementation with yeast or enzymes
No full textRumen fermentation kinetics of oil palm fronds (OPF) supplemented or not with enzymes (Hemicell® or Allzyme SSF®) or yeasts (Levucell®SC or Yea-Sacc®) were studied through an in vitro gas production test (96 h) (exp. 1). In exp. 2, enzymes were supplemented to OPF pre-treated during 3 or 9 wk with either one of five white rot fungi strains. Yeasts and enzymes were tested both in active and inactive forms, which revealed the most appropriate set-up to distinguish between the rate of supplements as direct contributors to the fermentation substrate vs. stimulators of the fermentation of the basal substrate. In exp 1, addition of active and inactive Yea-Sacc® increased the apparently rumen degradable carbohydrates (ARDC) by 11%, whereas enzymes did not affect rumen degradability of non-inoculated OPF. Neither yeast nor enzymes influenced the rate of gas production of non-inoculated OPF, except for active Hemicell® at the low dose. In exp. 2, inoculation of OPF with Ceriporiopsis subvermispora for 3 wk and Lentinula edodes for 9 wk increased ARDC, but additional enzyme supplementation did not further improve ARDC or the rate of gas production
The effect of the leukoreduction filtration moment on the clinical outcome of transfused patients: A retrospective cohort study
No full textIntroduction: Leukoreduction is performed to decrease the occurrence of adverse effects of transfusion, and can be performed by pre-storage (bench or in-line) or post-storage filtration (bedside) moment. The authors verified the effect of the leukoreduction filtration moment of Red Blood Cell (RBC) and Platelet Concentrate (PC) on the occurrence of Adverse Transfusion Reactions (ATRs), the presence of Healthcare-Associated Infections (HAIs), Length of Hospital Stay (LOS), and hospital death. Methods: Retrospective cohort conducted at the Hospital das Clínicas of the Medicine Faculty of the University of São Paulo, and at the Fundaçao ˜ Pró-Sangue Hemocentro in São Paulo, Brazil. Adult patients, hospitalized for >24 hours, who received leukoreduced RBC and/or PC transfusion between 2017‒2020 were included. The generalized mixed effects model and the Wald test were applied in the analysis with a significance level of 5%. Results: The authors evaluated 3668 patients who received 23,782 transfusions and we found no evidence of a leukoreduction filtration moment effect for ATR (p = 0.991) or HAI (p = 0.982), regardless of the transfused blood component. Meanwhile, the leukoreduction filtration moment had an effect (p < 0.001) on LOS, depending on the blood component transfused (p = 0.023), with pre-storage RBC filtration showing better performance, while in-line filtration stood out for PC. Both the leukoreduction filtration moment and the blood component (p = 0.041) influenced hospital death, with emphasis on the protective effect of bench RBC filtration and prestorage PC filtration. Conclusion: The leukoreduction filtration moment associated with the blood component had an effect on the LOS and hospital death of patients undergoing transfusion
The Minnesota Daily: January 7, 1955
No full textThis issue of the Minnesota Daily has been scanned from a microfilm copy of the original. It is representative of the physical copy it was scanned from, including duplicate pages, missing pages, or illegible pages. Paper copies of this issue of the Daily may also be held by the University of Minnesota Archives, and can be viewed by appointment.The Minnesota Daily. (1955). The Minnesota Daily: January 7, 1955. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/238564
Academic library non/low use and undergraduate student achievement: a preliminary report of research in progress
No full textPurpose: Reports an ongoing investigation of library use at Huddersfield University that has identified a historical correlation between Library usage and degree classification.
Approach: Three sets of data - use of electronic resources, book loans, and visits to the library – when represented graphically show consistent amounts of no and low use at campus, academic school, degree-type and course level. Combining these findings with data showing academic achievement raises the question: is there a positive correlation between library use and attainment?
Findings: Understandably Library usage varies between academic schools and there are often pedagogic reasons for low usage, but it would appear that, in some subjects, students who ‘read’ more, measured in terms of borrowing books and accessing electronic resources, achieve better grades.
Limitations: Further work will focus on undergraduate, fulltime students at the main University campus.
Implications: The research intends to discover the reasons behind non/low use so as to develop then trial effective interventions for improving the grades of all students, from the bottom up, rather than just supporting those that are already high flyers. The results will inform both Library service delivery and University goals concerning the quality of the student learning experience, improving retention and improving the level of final degree award.
Originality: There are implications for all subjects and all levels of achievement at the University
Linguistic Historiography of the sensible in Brazilian semiotics of discourse
No full textDiscussão e andamento de dados coletados para pesquisa de pós-doutorado. Perguntas para as entrevistas com os grupos de Pesquisa. Espelhos do DGP dos grupos e relatório de consulta parametrizada no DGP.CAPESCAPES/PRINT nº 88887.310463/2018-0088887.572732/2020-0
Clinical covariates influencing clinical outcomes in primary membranous nephropathy
No full textAbstract Background Primary membranous nephropathy (PMN) frequently causes nephrotic syndrome and declining kidney function. Disease progression is likely modulated by patient-specific and therapy-associated factors awaiting characterization. These cofactors may facilitate identification of risk groups and could result in more individualized therapy recommendations. Methods In this single-center retrospective observational study, we analyze the effect of patient-specific and therapy-associated covariates on proteinuria, hypoalbuminemia, and estimated glomerular filtration rate (eGFR) in 74 patients diagnosed with antibody positive PMN and nephrotic-range proteinuria (urine-protein-creatinine-ratio [UPCR] ≥ 3.5 g/g), treated at the University of Freiburg Medical Center between January 2000 – November 2022. The primary endpoint was defined as time to proteinuria / serum-albumin response (UPCR ≤ 0.5 g/g or serum-albumin ≥ 3.5 g/dl), the secondary endpoint as time to permanent eGFR decline (≥ 40% relative to baseline). Results The primary endpoint was reached after 167 days. The secondary endpoint was reached after 2413 days. Multivariate time-to-event analyses showed significantly faster proteinuria / serum-albumin response for higher serum-albumin levels (HR 2.7 [95% CI: 1.5 – 4.8]) and cyclophosphamide treatment (HR 3.6 [95% CI: 1.3 – 10.3]). eGFR decline was significantly faster in subjects with old age at baseline (HR 1.04 [95% CI: 1 – 1.1]). Conclusion High serum-albumin levels, and treatment with cyclophosphamide are associated with faster proteinuria reduction and/or serum-albumin normalization. Old age constitutes a risk factor for eGFR decline in subjects with PMN
Aqueous geochemistry of the rare earth elements in marine anoxic basins
No full textLife in the oceans mainly occurs in the upper tens of meters of the watercolumn,
where sunlight penetrates. This sunlight is used by phytoplankton to combine carbon and
nutrients to organic matter, which subsequently serves zooplankton and higher life forms as
food. When the plankton dies it slowly settles to the seafloor, meanwhile being decomposed
by bacteria. This decomposition requires oxygen, which is extracted directly from the
surrounding seawater. If this oxygen would not be constantly replenished, the oceans would
soon be completely devoid of oxygen (anoxic). Oxygen is replenished slowly by diffusion and
more readily by advection i.e. by supply of oxygen-rich water. If advection is locally
impeded, then mere diffusion is usually not sufficient to balance the consumption of oxygen
and an anoxic basin may be formed. This is the case for instance in the Bannock Basin,
eastern Mediterranean, where a volume of brine does not mix with the overlying seawater,
and in the Black Sea, where seawater that is supplied at depth through the Bosporus mixes
poorly with freshwater that is supplied at the surface by several major rivers.
Very interesting is the behaviour of certain trace metals in the waters of anoxic
basins, in particular at the interface between the oxygen-poor and the overlying oxygenrich
waters. Manganese and iron are present in oxygen-rich waters mainly as poorly
soluble oxides adsorbed onto particulate matter. When the particulate matter settles across
the interface, manganese and iron are reduced to a valency that does not form poorly soluble
oxides. As a result, the concentrations of dissolved manganese and iron strongly increase
across the interface. This leads to upward diffusion of dissolved manganese and iron into the
oxygen-rich waters, where they are once more oxidized and adsorbed onto particulate
matter. This cycling closely resembles a process whereby dissolved trace metals are
removed from the seawater in the upper part of the watercolumn by adsorption onto
particulate matter and released at depth as the particulate matter is decomposed. This
process, known as 'scavenging', is the major mechanism for the transport of trace metals
from the seawater to the sediment and constitutes an important component of the cycling of
trace metals in the oceans. Scavenging is difficult to study, since it occurs on a worldwide
scale and on timescales of hundreds to thousands of years. By studying the cycling of trace
metals at the interface between oxygen-poor and oxygen-rich waters in anoxic basins, a
similar process that is however localized and occurs on considerably shorter timescales,
much can indirectly be learned about scavenging.
The rare earth elements or lanthanides are very well Suited for this purpose. Their
cycling in the oceans seems to be governed by the same mechanisms that govern the cycling
of many other trace metals and is in particular closely associated with the cycling of
manganese. At the interface between oxygen-poor and oxygen-rich waters in anoxic basins
they show a passive cycling that seems to be driven by the cycling of manganese and possibly
also by that of iron. Moreover, the element cerium shows an active cycling that is caused by
its own oxidation-reduction chemistry, a property that is unique within the rare earth
element series. The rare earth elements form a chemically coherent group, yet their
chemical properties are not completely the same. Consequently, the cycling of each rare
earth element is subtly different from that of all others. Since the chemical properties of
the rare earth elements depend in a gradual and more or less predictable way on atomic
number, the mechanisms that govern the cycling of the rare earth elements in the ocean and
at the interface between oxygen-poor and oxygen-rich waters in anoxic basins can be
studied and described in terms of relative rather than absolute behaviour. In fact, the
behaviour of the rare earth elements as a group forms a frame of reference for the
behaviour of each rare earth element separately. By studying the cycling of the rare earth
elements, information can indirectly be obtained about the cycling of trace metals like
manganese and iron, for which such a frame of reference is not availabl
Cartografia do sensível: as relações entre o inteligível e o sensível na semiótica discursiva
No full textEste trabalho teve como objetivo principal compreender, em que medida, existe uma episteme de ordem sensível na semiótica, por meio da historiografia linguística, contextualizando seu surgimento e sua permanência nos estudos semióticos discursivos contemporâneos. Estabelecemos, portanto, uma cartografia do sensível, sendo este visto como hiperônimo do campo e os outros conceitos circunscritos nele, os seus domínios (a corporeidade, a passionalidade e a sensibilidade). Recuperamos a espessura teórica desses conceitos pelos princípios historiográficos de K. Koerner (1996), de P. Swiggers (2009) e de S. Auroux (2008). Definimos nas análises como o sensível aparece na retórica e na imanência das obras dos semioticistas Greimas, Fontanille, Landowski e Zilberberg. Após ter estabelecido os desdobramentos conceituais do sensível, finalmente, conseguimos definir o lugar histórico de uma semiótica, hoje, considerada do sensível, explicitando se o mesmo ocorre no nível epistemológico da disciplina.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Versão final do editorUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, AraraquaraCAPES/PRINT nº 88887.310463/2018-0
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