1,721,055 research outputs found
Expression of endothelin-1 and endothelin-1 receptor A in canine mammary tumours
Full text linkEndothelins and their receptors have been implicated in numerous diseases and have recently emerged
as relevant players in a variety of malignancies. Tumours overexpress the Endothelin-1 (ET-1) and the
Endothelin-A receptors (ETAR) and their interaction enhances tumour growth and metastasis by promoting
tumour cell survival, proliferation and angiogenesis. In this study we have evaluated the expression
of ET-1 and ETAR in 50 canine mammary tumours, compared to normal controls. Results demonstrated
a progressive increase in ET-1 and ETAR expression from benign tumour to grade 1 and to grade 2 malignant
mammary tumours with a decrease of expression in grade 3 carcinomas. Co-localization of ET-1
and ETAR was observed in benign mammary tumours and in G1 and G2 carcinomas, while absent in G3
carcinomas. Concluding, ET-1/ETAR can be considered reliable markers for evaluating malignancy of canine
mammary tumours and could have importance for the development of specific anticancer therapies
IMPORTANZA DELL’ESAME ANATOMO-ISTO-PATOLOGICO NELLA DIAGNOSI DELLE PIU’ COMUNI MALATTIE DELLE API.
No full textValutazione dell’angiogenesi mediante analisi morfometrica nelle lesioni displastiche e neoplastiche della cavità orale del cane .
No full textDetection of Honeybee Viruses in Vespa orientalis
No full textThe Oriental hornet (Vespa orientalis) is spreading across the Italian territory threatening the health and wellbeing of honeybees by feeding on adult individuals and larvae and by plundering hive resources. Considering the capacity of other hornets in harboring honeybee viruses, the aim of this study was to identify the possible role of the Oriental hornet as a vector for honeybee viruses. Adult hornets were subjected to macroscopical examination to identify the presence of lesions, and to biomolecular investigation to detect the presence of six honeybee viruses: Acute Bee Paralysis Virus (ABPV), Black Queen Cell Virus (BQCV), Chronic Bee Paralysis Virus (CBPV), Deformed Wing Virus (DWV), Kashmir Bee Virus (KBV), Sac Brood Virus (SBV). No macroscopical alterations were found while biomolecular results showed that DWV was the most detected virus (25/30), followed by ABPV (19/30), BQCV (13/30), KBV (1/30) and SBV (1/30). No sample was found positive for CBPV. In 20/30 samples several co-infections were identified. The most frequent (17/30) was the association between DWV and ABPV, often associated to BQCV (9/17). One sample (1/30) showed the presence of four different viruses namely DWV, ABPV, BQCV and KBV. The detected viruses are the most widespread in apiaries across the Italian territory suggesting the possible passage from honeybees to V. orientalis, by predation of infected adult honeybees and larvae, and cannibalization of their carcasses. However, to date, it is still not clear if these viruses are replicative but we can suggest a role as mechanical vector of V. orientalis in spreading these viruses
- …
