93 research outputs found
Carlo Gozzi, La Marfisa bizzarra: edizione critica e storia del testo
No full textIl presente lavoro, suddiviso in due tomi allo scopo di rendere più agevole la lettura, consiste in un'edizione critica del poema faceto di Carlo Gozzi La Marfisa bizzarra. Il primo tomo comprende:
l'analisi della storia compositiva dell'opera; un apparato genetico; un commento, principalmente di
carattere linguistico-filologico con rimandi al contesto storico-culturale, e un'appendice contenente
diverso materiale documentario. Il secondo offre invece il testo nella sua interezza.
Nella prima parte della tesi viene analizzato il farsi dell'opera, dalla genesi, alla prima edizione fino alla progettazione di una seconda, mai uscita vivente l'autore, dando spazio ai materiali emersi dal recente rinvenimento del Fondo Gozzi i quali, unitamente ai testimoni già noti, permettono di ricostruire nel dettaglio il modus operandi gozziano. Il testo critico riproduce l'ultima volontà dell'autore, si è quindi scelto di adottare, per la prima redazione, quello della stampa Colombani emendato di eventuali errori, mentre per le
interpolazioni, in prosa e poesia, e le correzioni della seconda si è optato per la lezione apografa,presente nel manoscritto che fu anche antigrafo dell'edizione Colombani. Tale lezione è attribuibile a Raffaele Todeschini, amico e notaio di fiducia di Carlo. Il manoscritto fa parte di una delle nuove acquisizioni del Fondo Gozzi. Le varianti tra le due principali redazioni sono fornite in un apparato a piè di pagina.The present work, divided into two tomes for a simpler reading, consists of a critical edition of facetious poem La Marfisa bizzarra by Carlo Gozzi. The first tome incudes: an analysis of the history of poem composition, a genetic apparatus, a mainly linguistic-philologic comment with hystorical-cultural links and a documentarial appendix. The second one presents the complete poem. In the first part, the poem composition was analysed from the ideation through the first edition and until the second one project, even if this latter was not pubblished during Gozzi's life. New materials recently discovered in Fondo Gozzi, togheter with already known witnesses, allow the recostruction of Gozzi's modus operandi.
The critical test presents the last author's will, thus for the first editing, the Colombani print is chosen, amending the eventual mistakes, while for the additions and the corrections of the second one, the apograph text, attributed to Raffaele Todeschini, Gozzi's friend and notary, was used. This latter is found in Fondo Gozzi and it is present in the same manuscript, which was used as a model for Colombani print, and after was incremented by Todeschini. The variants between the two main redactions are presented in an apparatus at the foot of the page
Vein Suturing Results in Worse Lung Graft Outcomes Compared to the Cuff Method
No full textBackground: The rat orthotopic lung transplant model is not widely used yet because of the complexity of the procedure, in particular, venous anastomosis. Here, we performed a rat orthotopic lung transplantation using either the suture (ST) or cuff (CT) method for vein anastomosis. Objectives: To compare the vein ST and CT techniques in terms of operative time, success, recipient survival, and early histological outcomes was the objective of this study. Methods: A total of 24 left lung transplants in rats were performed. Twelve syngeneic (Lewis to Lewis) and 12 allogeneic (Brown-Norway to Lewis) lung transplants were performed using either the vein ST or the CT procedure. Arterial and bronchial anastomoses were performed with the CT technique. Graft histological damage was evaluated 3-7 days post-transplant in all rat lungs. Results: The surgical success rate was 75% in both the ST and CT groups. Failures related mainly to vein bleeding (n = 2 in the ST group) and thrombosis (n = 1 in the ST group; n = 2 in the CT group). Total ischemia time was longer in the ST group (122 ± 25 min in ST group vs. 83 ± 10 min in CT group, mean ± SD), due to prolonged warm ischemia time (60 ± 12 min in the ST group vs. 21 ± 5 min in the CT group, mean ± SD), reflecting the time required to complete the vein ST procedure. The prolonged warm ischemia time resulted in significantly higher vascular inflammation in syngeneic grafts (2.3 ± 1.2 ST group vs. 0 in the CT group, mean ± SD) and in increased severity of ischemia/reperfusion injury and acute graft rejection (3.6 ± 0.4 in the ST group vs. 2.6 ± 0.4 in the CT group, mean ± SD) in allogeneic lung transplants. Conclusions: The vein ST technique is a more time-consuming procedure than the CT method and the prolonged anastomosis time has a deleterious impact on transplant outcomes. These findings suggest that warm ischemia time - one of the modifiable transplant factors - should be considered a major risk factor in lung transplantation, particularly in the setting of donation after cardiac death
A Code Completion System for the Catrobat Visual Programming Language
No full textCode completion systems are increasingly popular in the computer programming world. This thesis describes the design of a code completion system within the visual programming language Catrobat, with the aim of making programming more accessible to younger and less experienced users. This system was subsequently implemented into an application developed for Android devices, Pocket Cod
A Code Completion System for the Catrobat Visual Programming Language
No full textCode completion systems are increasingly popular in the computer programming world. This thesis describes the design of a code completion system within the visual programming language Catrobat, with the aim of making programming more accessible to younger and less experienced users. This system was subsequently implemented into an application developed for Android devices, Pocket Codeope
Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases
No full textIntroductionIn autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells. However, current first-line treatments rely on non-specific and general suppression of the immune system, exposing patients to severe side effects. For this reason, identification of targeted therapies for autoimmune diseases is an unmet clinical need.MethodsHere, we designed a novel class of immunotherapeutic molecules, Bi-specific AutoAntigen-T cell Engagers (BiAATEs), as a potential approach for targeting the small subset of autoreactive B cells. To test this approach, we focused on a prototype autoimmune disease of the kidney, membranous nephropathy (MN), in which phospholipase A2 receptor (PLA2R) serves as primary nephritogenic antigen. Specifically, we developed a BiAATE consisting of the immunodominant Cysteine-Rich (CysR) domain of PLA2R and the single-chain variable fragment (scFv) of an antibody against the T cell antigen CD3, connected by a small flexible linker.ResultsBiAATE creates an immunological synapse between autoreactive B cells bearing an CysR-specific surface Ig+ and T cells. Ex vivo, the BiAATE successfully induced T cell-dependent depletion of PLA2R-specific B cells isolated form MN patients, sparing normal B cells. Systemic administration of BiAATE to mice transgenic for human CD3 reduced anti-PLA2R antibody levels following active immunization with PLA2R.DiscussionShould this approach be confirmed for other autoimmune diseases, BiAATEs could represent a promising off-the-shelf therapy for precision medicine in virtually all antibody-mediated autoimmune diseases for which the pathogenic autoantigen is known, leading to a paradigm shift in the treatment of these diseases
Uterine serous papillary carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody
No full textUterine serous papillary carcinoma (USPC) was an aggressive and chemotherapy resistant variant of endometrial cancer. The authors evaluated the expression of human trophoblast-cell-surface-marker (Trop-2) and the potential of hRS7, a humanized anti-Trop-2 monoclonal antibody, as a novel therapeutic strategy against USPC
High-grade, chemotherapy-resistant primary ovarian carcinoma cell lines overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody
No full textWe evaluated the expression of human trophoblast cell-surface marker (Trop-2) and the potential of hRS7, a humanized monoclonal anti-Trop-2 antibody, as a therapeutic agent against chemotherapy-resistant ovarian disease
Safety of Monkeypox Vaccine Using Active Surveillance, Two-Center Observational Study in Italy
No full textIn August 2022, Italy launched a vaccination campaign to combat the spread of the monkeypox virus, which the WHO has designated as a public health emergency. Priority targets for the campaign included laboratory personnel and men who have sex with men with specific risk criteria. Primary immunization involved two doses of the Imvanex/Jynneos vaccine, followed by a single booster dose. We conducted a study in two Italian towns, Bologna and Forl ì, in October and November 2022 to investigate adverse events following immunization (AEFIs) of the monkeypox vaccine through participant-based active surveillance. Participants who received the vaccine and were aged 18 and over were invited to complete an e-questionnaire by scanning a QR code during their second vaccine appointment or by email one month after the booster dose. A descriptive analysis of AEFI incidences was conducted, with the results stratified by type and severity of symptoms. A total of 135 first-dose, 50 second-dose, and 6 single-dose recipients were included, with a mean age of 36.4 & PLUSMN; 8.7 years. Systemic reactions after the first and second doses were reported by 39.3% and 26.0% of participants, respectively, with asthenia being the most common symptom. Local site reactions were reported by 97.0% and 100.0% of participants, respectively, with redness, swelling, and itching being the most common local AEFIs. Grade 3 or 4 AEFIs were reported for local AEFIs only by 16.8% and 14.0% of participants after the first and second doses, respectively. Our findings suggest that the monkeypox vaccine has a high tolerability profile in terms of short-term common systemic AEFIs. However, the high incidence and severity of local AEFIs highlight the need to monitor their persistence following intradermal administration of the vaccine
Chapter Spazi e tempi della libertà economica
No full textThe author focuses on the urban world to reformulate the question traditionally interpreted in terms of the entrepreneurial freedom of late medieval merchants: even in this context the notion of libertas, rather than absolutely defining the economic action of groups or people, was related in terms functional to their social and political qualities. The analysis of Italian city legislation, in particular of the regulations of the arts and of the market, highlights how the different degrees of belonging to the civitas guaranteed the spaces for economic action and commercial times: full freedom remained firmly in the hands of a few family groups and privileged while in the market squares of Italian cities farmers, artisans and traders and the vast world of subordinate work were destined to remain subordinate actors
Consenso informato: dal buio alla luce. Andata e… pericoloso ritorno?
No full textOver the last years, the principle of informed consent has gained considerable importance in the doctrinal elaboration and approaches, as well as juridical interpretations, thereby influencing the everyday activities of the medical profession. It tends to reflect the concept of autonomy and decisional auto determination of the person requiring medical or surgical interventions. The correct informed consent requires that the healthcare provider gives the patient all the information necessary for a knowledgeable decision on the proposed procedure. In order for the patient to be presented with sufficient information to make an informed decision, several elements are necessary, regarding diagnosis, purpose of proposed treatment, possible risks and benefits of proposed treatment, possible alternatives to proposed treatment and possible risks of not receiving treatment. Informed consent is still the object of continuous explorations. In this article, the Author analyses the doctrine of informed consent in the Italian contest, describing some decisions of the Court that are useful to explore all the aspects of the subject
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