1,588 research outputs found
Richard Hell, 20th Annual ODU Literary Festival
No full textRichard Hell musician, poet, and novelist is best known for his album with the Voidoids, “Blank Generation.” William Gibson has said, “Go Now is a vile, scabrous, unforgivable novel and deserving of the widest possible audience.” Hell is also the author of several books of poems including I Was a Spiral on the Floor (Soyo Publications, 1988), Across The Years, and Wanna Go Out, collaborative poems with Tom Verlain. His work has been widely anthologized in collections such as Out of this World (poems, Crown Publishers, 1992), and Jungles D’Ameriques (fiction, AAC Editions, Paris, 1993). Hell currently lives and writes in New York City
Single-Molecule STED Microscopy with Photostable Organic Fluorophores
No full textKasper R, Harke B, Forthmann C, Tinnefeld P, Hell SW, Sauer M. Single-Molecule STED Microscopy with Photostable Organic Fluorophores. SMALL. 2010;6(13):1379-1384
The fire that reconciles : theological reflections on the doctrine of eternal punishment, with special consideration of annihilationism and traditionalism
No full textThis study enters into the dialog within Christian theology between annihilationism and traditionalism on the nature of eternal punishment. The positions and issues within the topic will be examined theologically and analyzed doctrinally.
In my first chapter I will summarize the views and arguments in the debate, establish operating definitions, address preliminary issues, and provide some historical context. I will establish a thesis agenda with dual aspects: negatively, to examine and critique annihilationism on theological grounds, and positively to offer arguments for a modified traditionalism.
Chapters two, three, and four primarily serve the negative purpose. Chapter two critically considers annihilationism on exegetical and hermeneutical issues, concluding that the view is inferior to traditionalism. Chapter three examines annihilationism for consistency with other areas of Christian theology, concluding that the view generates major theological problems in Christology. Chapter four considers both annihilationism and traditionalism regarding the disproportionality problem of hell, concluding that annihilationism and two types of traditionalism can resolve the problem but of these three only one sort of traditionalism can do so whilst also satisfying other important theological criteria. Regarding the negative aspect of the thesis, I conclude that the severe theological problems in annihilationism constitute sufficient reason to reject the view.
In chapter five I accomplish the positive aspect of this thesis, offering six criteria of success for any view of eternal punishment. I then provide detailed argumentation for a modified traditionalism called reconciliationism, concluding it best meets these criteria and is the most theologically and exegetically satisfying view on offer. In the concluding chapter I state this thesis’ contributions, suggest several areas for further research, and offer some implications for pastoral theology.
I finally conclude that annihilationism has seemingly insurmountable theological problems, but a modified traditionalism can succeed as a doctrine of hell
Ectopically expressed glutaredoxin ROXY19 negatively regulates the detoxification pathway in Arabidopsis thaliana
No full textBackground: Glutaredoxins (GRXs) are small proteins which bind glutathione to either reduce disulfide bonds or to coordinate iron sulfur clusters. Whereas these well-established functions are associated with ubiquitously occurring GRXs that encode variants of a CPYC or a CGFS motif in the active center, land plants also possess CCxC/S-type GRXs (named ROXYs) for which the biochemical functions are yet unknown. ROXYs physically and genetically interact with bZIP transcription factors of the TGA family. In Arabidopsis, ectopically expressed ROXY19 (originally named GRX480 or GRXC9) negatively regulates expression of jasmonic acid/ethylene-induced defense genes through an unknown mechanism that requires at least one of the redundant transcription factors TGA2, TGA5 or TGA6. Results: Ectopically expressed ROXY19 interferes with the activation of TGA-dependent detoxification genes. Similar to the tga2 tga5 tga6 mutant, 35S:ROXY19 plants are more susceptible to the harmful chemical TIBA (2,3,5-triiodobenzoic acid). The repressive function of ROXY19 depends on the integrity of the active site, which can be either CCMC or CPYC but not SSMS. Ectopic expression of the related GRX ROXY18/GRXS13 also led to increased susceptibility to TIBA, indicating potential functional redundancy of members of the ROXY gene family. This redundancy might explain why roxy19 knock-out plants did not show a phenotype with respect to the regulation of the TIBA-induced detoxification program. Complementation of the tga2 tga5 tga6 mutant with either TGA5 or TGA5C186S, in which the single potential target-site of ROXY19 had been eliminated, did not reveal any evidence for a critical redox modification that might be important for controlling the detoxification program. Conclusions: ROXY19 and related proteins of the ROXY gene family can function as negative regulators of TGA-dependent promoters controlling detoxification genes
The Role of Hell in Various Universalistic Theologies with Special Reference to the Theology of George MacDonald
No full textDegree Awarded: Ph.D. Systematic Theology. The Catholic University of AmericaA significant tension exists regarding the existence and purpose of hell between the majority Christian tradition and the Universalist tradition within Christianity. Seeking a resolution of that tension, this dissertation examines the use of hell in three main types of Christian Universalism and evaluates this usage using five criteria: Consonance of the use of hell with paradigmatic elements of scripture, the permanence of hell, impetus for evangelization in light of the use of hell, hell's discontinuity with creation, and the possibility of hell for persons other than Christ. The three models evaluated are the Pedagogical Model characterized by Origen, the Christocentric Model characterized by Karl Barth and Hans Urs von Balthasar, and the Moral Impetus Model characterized by Hans Urs von Balthasar and Raymund Schwager. These three models are demonstrated to each be strong in some areas of evaluation, but weak in other areas.In response to the weaknesses of each of the models examined, the author begins to explore the theology of the nineteenth century author and preacher George MacDonald, who believed that Christ would save all people. A chapter is dedicated to exploring MacDonald's theology of revelation as well as his theological anthropology. These two aspects of his theology are then followed by a description of his understanding of hell which answers many of the problems which exist in other models of hell. He is shown to be strong in the criteria of consonance with scripture, impetus for evangelization, hell's discontinuity with creation, and the possibility of hell for those other than Christ.To address possible questions of permanence in MacDonald's theology of hell, and to work forward to bring MacDonald's theology into dialog with contemporary discussions of universalism and eschatology, the final chapter takes as its point of departure the ancient image of the eschatological community of God going out to see the punishments of the damned and to rejoice over them. A theory of revelation as persons is put forward in continuity with MacDonald's revelatory anthropology as a way to address problems of identity in the community of the blessed and the reality of hell. Drawing on Johannine and Pauline descriptions of identity change, the author demonstrates a permanence of final condemnation of the "old Adam" in the permanent presence of the blessed community
Not a Hope in Hell
No full textIt is frequently claimed that an all-loving and good God cannot permit anyone to end up in hell. In this book, the author shows that this issue of God’s permission of hell has an intimate connection with age-old questions regarding why God would permit sin. Indeed, focus on why an all-loving and good God would permit hell is the best lens through which to explain sin.
Many arguments against the possibility of hell require affirming that God permits sin because God could not achieve goods for us without allowing sin. The author argues that we have independent philosophical reasons to reject that sin is necessary for us in any way, and, further, we have similar reasons to hold that hell is necessarily possible if the God of classical theism exists. In the end, understanding why an all-loving and good God would permit hell reveals that there is always hope for us, even when things appear most hopeless.
The book will appeal to those working in metaphysics, theology, philosophy of religion, and medieval philosophy
Not a Hope in Hell
No full textIt is frequently claimed that an all-loving and good God cannot permit anyone to end up in hell. In this book, the author shows that this issue of God’s permission of hell has an intimate connection with age-old questions regarding why God would permit sin. Indeed, focus on why an all-loving and good God would permit hell is the best lens through which to explain sin.
Many arguments against the possibility of hell require affirming that God permits sin because God could not achieve goods for us without allowing sin. The author argues that we have independent philosophical reasons to reject that sin is necessary for us in any way, and, further, we have similar reasons to hold that hell is necessarily possible if the God of classical theism exists. In the end, understanding why an all-loving and good God would permit hell reveals that there is always hope for us, even when things appear most hopeless.
The book will appeal to those working in metaphysics, theology, philosophy of religion, and medieval philosophy
Sulfate-induced stomata closure requires the canonical ABA signal transduction machinery
No full textPhytohormone abscisic acid (ABA) is the canonical trigger for stomatal closure upon abiotic stresses like drought. Soil-drying is known to facilitate root-to-shoot transport of sulfate. Remarkably, sulfate and sulfide—a downstream product of sulfate assimilation—have been independently shown to promote stomatal closure. For induction of stomatal closure, sulfate must be incorporated into cysteine, which triggers ABA biosynthesis by transcriptional activation of NCED3. Here, we apply reverse genetics to unravel if the canonical ABA signal transduction machinery is required for sulfate-induced stomata closure, and if cysteine biosynthesis is also mandatory for the induction of stomatal closure by the gasotransmitter sulfide. We provide genetic evidence for the importance of reactive oxygen species (ROS) production by the plasma membrane-localized NADPH oxidases, RBOHD, and RBOHF, during the sulfate-induced stomatal closure. In agreement with the established role of ROS as the second messenger of ABA-signaling, the SnRK2-type kinase OST1 and the protein phosphatase ABI1 are essential for sulfate-induced stomata closure. Finally, we show that sulfide fails to close stomata in a cysteine-biosynthesis depleted mutant. Our data support the hypothesis that the two mobile signals, sulfate and sulfide, induce stomatal closure by stimulating cysteine synthesis to trigger ABA production
associated with previously unreported features of Cohen syndrome
No full textCohen syndrome (CS) is a rare autosomal recessive disorder associated with mutations in the vacuolar protein sorting 13 homolog B (VPS13B; formerly COH1) gene. The core clinical phenotype comprises a characteristic facial gestalt, marked developmental delay, and myopia. Additional, nonobligatory features include obesity, microcephaly, short stature, muscular hypotonia, scoliosis, narrow hands and feet, progressive retinopathy, as well as neutropenia. Here we report a novel homozygous nonsense mutation in the VPS13B gene and previously undescribed clinical features in a 19-year-old woman with developmental delay, intellectual disability, and a particular facial appearance. The patient showed several features consistent with CS. In addition, the parents observed congenital alacrima and anhidrosis persisting until onset of puberty. The diagnosis was not established based on the clinical phenotype. We performed whole-genome sequencing and identified a novel homozygous nonsense mutation c.62T>G (NM_152564.4), p.(Leu21 ) in the VPS13B gene. Our findings extended the previously reported phenotype of CS. We conclude that transient, prepubertal alacrima and anhidrosis are part of the phenotypic spectrum of CS associated with a novel homozygous nonsense mutation in the VPS13B gene.Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/50110000165
Seasons in Hell: Covering the Bosnia War
No full textA public presentation by British Journalist Ed Vulliamy, author of Seasons in Hell: Understanding Bosnia\u27s War.
Free and open to the public
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