2,904 research outputs found
Rapporteur’s report – innovative geotechnologies for energy transition
No full textThe 9th Society for Underwater Technology (SUT) International Conference on Offshore Site Investigation and Geotechnics (OSIG) closed with a Rapporteur’s report given by the author. This paper provides a record of that report, transcribed from a video recording. The presentation slides are shown as Figures.</p
DEFRApH - Sample collection and handling procedures
No full textAll chemical and biogeochemical process in the sea are affected by the acidity of the water. Acidity is therefore fundamental property of seawater. The growing concern that the acidity of the oceans might be increasing has revealed weaknesses in our knowledge of this fundamental property and its variation in space and time. In 2008 the DEFRApH project (DEFRA contract ME4133) was initiated to provide this missing information in UK related waters. It required sampling for and analysis of the total inorganic carbon and total alkalinity content of samples. This reports documents the procedures sued for sampling. A companion document Hartman Dumousseaud and Roberts (NOC Internal Document No. 01) describes in detail the analytical procedures used and the calculation of the results
Author Correction:Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention (Nature Communications, (2019), 10, 1, (5280), 10.1038/s41467-019-13244-9)
No full textThe original version of this Article contained an error in the spelling of the author Wilma D.J. van de Berg, which was incorrectly given as Wilma D.J. van den Berg. This has now been corrected in both the PDF and HTML versions of the Article.</p
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Representing citizens and consumers in media and communications regulation
No full textWhat do citizens need from the media, and how should this be regulated? Western democracies are witnessing a changing regulatory regime, from "command-andcontrol" government to discursive, multistakeholder governance. In the United Kingdom, the Office of Communications (Ofcom) is required to further the interests of citizens and consumers, which it does in part by aligning them as the citizen-consumer. What is meant by this term, and whether it captures the needs of citizens or subordinates them to those of consumers, has been contested by civil society groups as well as occasioning some soul-searching within the regulator. By triangulating a discursive analysis of the Communications Act 2003, key actor interviews with the regulator and civil society bodies, and focus groups among the public, the authors seek to understand how these terms ("citizen," "consumer," and "citizen-consumer") are used to promote stakeholder interests in the media and communications sector, not always to the benefit of citizens
Reply to the discussion by McCarron on “Modelling spatial variability in as-laid embedment for high pressure and high temperature (HPHT) pipeline design”
No full textN/AThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
William Colbeck (Vignette)
No full textOpening paragraph:People from Hull and the East Riding of Yorkshire played a significant role in the ‘Heroic Age’ of Antarctic Exploration (1897-1922). Clements Markham, the President of the Royal Geographical Society, who envisaged and oversaw the British National Antarctic Expedition (1901-1904), came from Stillingfleet, East Yorkshire. Much of the money required to fund the expedition was provided by Llewellyn Longstaff, owner of Hull’s Blundell’s Paints. And a key player in the celebrated Antarctic expeditions was Captain William Colbeck of Hull
William Colbeck (Vignette)
No full textOpening paragraph:People from Hull and the East Riding of Yorkshire played a significant role in the ‘Heroic Age’ of Antarctic Exploration (1897-1922). Clements Markham, the President of the Royal Geographical Society, who envisaged and oversaw the British National Antarctic Expedition (1901-1904), came from Stillingfleet, East Yorkshire. Much of the money required to fund the expedition was provided by Llewellyn Longstaff, owner of Hull’s Blundell’s Paints. And a key player in the celebrated Antarctic expeditions was Captain William Colbeck of Hull
Wavelength tunable 10-GHz 3-ps pulse source using a dispersion decreasing fiber-based nonlinear optical loop mirror
No full textWe experimentally demonstrate the use of a dispersion decreasing fiber (DDF)-based nonlinear optical loop mirror (NOLM) for the generation of wavelength tunable soliton-like pulses at a repetition rate of 10 GHz. We compress ~12 ps Gaussian pulses from an electro-absorption modulator (EAM) (followed by 125 m of DCF for preliminary linear dispersion compensation) into 3 ps pedestal-free pulses using both high-order soliton compression and nonlinear switching effects within an 8.5 km DDF-based loop mirror. The output pulses from the DDF-based NOLM show considerable pedestal reduction compared to those obtained by directly compressing the EAM seed pulses via a single passage through the DDF. Wavelength tuning of the compressed pulses over a ~15 nm bandwidth (from 1541 to 1556 nm) is demonstrated without a significant increase in pulse duration or degradation in pulse quality
Conversation as a site of category learning and category use
No full textConversation is one of the primary settings of category learning and category use. People spend a large portion of their lives in conversation with other people, and these conversations invariably involve numerous categorizations of entities and situations. Referential communication involves relating language to the world. In reference, the goal of categorization is to establish joint attention on some entity with an interlocutor. Most categorization research can be said to have accepted the labeling as categorization hypothesis, given that the vast majority of studies signal category membership to the learner through the use of a symbolic label. An alternative to viewing labeling as a kind of categorization would be to view it as a kind of social mnemonic that allows people to share attention to an object without bearing the strong entailments involved in nonlinguistic categorization. The simplest definite description involves mentioning the name of a category to which the referent belongs. The lexicon of a language provides a rich, ready-made system of distinctions for classifying referents. This system is characterized by a hierarchical reorganization that makes it possible to classify referents at various levels of specificity: superordinate, basic, and subordinate
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